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src="https://tyunfile.71360.com/WaterMark/UploadFile/Accurantbio/637413936812749716/4530416.png" class="vcenter" onerror="javascript:this.src='/static/new_net_01/images/nopic.jpg';"></p></div></div><div id="f2na9ur" class="smallimg"><div><p class="pic"><img src="https://tyunfile.71360.com/WaterMark/UploadFile/Accurantbio/637413936812749716/4530416.png" class="vcenter" onerror="javascript:this.src='/static/new_net_01/images/nopic.jpg';"></p></div></div></div><div id="dsk3gya" class="content"><p><span>需求數(shù)量：</span>0</p><p><span>價格要求：</span>面議</p><p><span>所在地：</span>上海市</p><p><span>包裝要求：</span><span style="color: #f30;"></span></p><p><span>產(chǎn)品關(guān)鍵詞：</span>山東是什么大分子生物分析平臺,大分子生物分析平臺</p><p><span>***更新：</span>2021-01-21 05:08:55</p><p><span id="click" >瀏覽次數(shù)：0次</span></p><a rel="nofollow" class="button">聯(lián)系我們</a></div></div><div id="gqifofh" class="rightbox"><h3>公司基本資料信息</h3><p style="border:0;"><a rel="nofollow">寧波熙寧檢測技術(shù)有限公司</a></p><p><span>聯(lián)系人：</span>王蒙</p><p><span>郵箱: </span>meng.wang@accurantbio.com</p><p><span>電話: </span>13585708897</p><p><span>傳真: </span>0574_</p><p><span>網(wǎng)址: </span>https://www.accurantbio.com</p><p><span>手機: </span>0574-87878487</p><p><span>地址: </span>浙江省寧波市鄞州區(qū)聚賢路587弄A5幢4樓</p><p>[當前離線] <a rel="nofollow"> [加為商友] </a><a rel="nofollow"> [發(fā)送信件] </a></p></div></div><div id="jd3y7ub" class="page-proshow02"><p class="title">詳細說明</p><div id="8zbyne3" class="box"><p><p> 生物類似藥研發(fā)期間需要對生物類似藥和原研藥的PK進行頭對頭的比較。在進入驗證階段之前，應(yīng)仔細解讀方法開發(fā)過程中獲得的數(shù)據(jù)。 </p> <p> 在選擇檢測平臺時，首先要考慮待測藥物的固有性質(zhì)和分子特點（例如，藥物與其靶點之間特定的相互作用，以及在特定生物基質(zhì)中與可溶性受體和膜結(jié)合受體的復(fù)合物的產(chǎn)生情況）。其他參數(shù)如內(nèi)源性的藥物存在、基質(zhì)中的抗藥抗體、檢測靈敏度，山東是什么大分子生物分析平臺、檢測的動態(tài)范圍以及可使用的樣本量都應(yīng)考慮在內(nèi)。 </p> <p> 考慮到藥物開發(fā)的過程很長，臨床試驗的跨度長達數(shù)年，選擇一個相對穩(wěn)定的實驗平臺進行藥物的檢測就顯得至關(guān)重要。熙寧生物專注于大分子生物檢測。生物大分子藥物具有相對分子質(zhì)量大、不易透過生物膜，山東是什么大分子生物分析平臺，山東是什么大分子生物分析平臺、給藥劑量低、易在體內(nèi)降解等特點。精翰生物專注檢測。山東是什么大分子生物分析平臺</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="山東是什么大分子生物分析平臺,大分子生物分析平臺" src="https://tyunfile.71360.com/WaterMark/UploadFile/Accurantbio/637413936812749716/4530416.png"></div><p style="text-indent:25px">寧波熙寧檢測技術(shù)有限公司（AccurantBioTech Inc）是一家專業(yè)的符合國際GLP質(zhì)量標準的生物分析實驗室，可以為您提供注冊性臨床和臨床前流式細胞分析的一站式服務(wù)。在流式細胞分析領(lǐng)域，熙寧生物有豐富的經(jīng)驗積累，并且在不斷前行，希望在藥物研發(fā)和申報的道路上，可以為您提供強大的分析服務(wù)支持。流式細胞術(shù)（FCM）檢測MRD的原理是通過分析細胞表面或胞內(nèi)一系列抗原的表達模式（如圖一）來識別只在白血病細胞中出現(xiàn)而正常骨髓中不存在或存在比例極低的免疫表型，即“白血病相關(guān)免疫表型”(1eukemia-associatedimmunophenotypes，LAIP)。根據(jù)抗原表達特點將LAIP分為以下幾種表現(xiàn)形式：跨系抗原表達、非同步抗原表達、抗原表達量異常、散射光信號異常以及表達少數(shù)白血病特異性抗原。山東是什么大分子生物分析平臺胞內(nèi)細胞因子流式分析法是用抗細胞因子抗體與細胞表面或胞內(nèi)特定亞群標志物組合。</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="山東是什么大分子生物分析平臺,大分子生物分析平臺" src="https://tyunfile.71360.com/WaterMark/UploadFile/Accurantbio/637413936645923480/3353719.png"></div><p style="text-indent:25px"> 熙寧生物是一家專業(yè)的符合國際GLP&GCP質(zhì)量管理規(guī)范的大分子生物分析實驗室，為國內(nèi)外生物醫(yī)藥公司提供臨床和臨床前大分子生物分析的一站式服務(wù)，包括抗體制備，樣本采集包及實驗室手冊，符合法規(guī)要求的分析方法的開發(fā)和驗證，以及樣本分析。包含藥代動力學(PK)，藥效動力學(PD)，抗藥抗體(ADA)，中和抗體(NAb)，生物標志物(Biomarker)受體占位(RO)，以及基于流式細胞術(shù)(FACS)和熒光定量PCR (qPCR)平臺的針對新型細胞(CART ,CAR-NK)和基因藥物的PK, PD分析服務(wù)。</p><p style="text-indent:25px">TT4測定可用于甲亢、原發(fā)性和繼發(fā)性甲減的診斷以及TSH的監(jiān)測。增高：甲亢，高TBG血癥（妊娠，口服雌及口服避孕藥，家族性），急性甲狀腺炎，亞急性甲狀腺炎，急性肝炎，肥胖癥，應(yīng)用甲狀腺時，進食富含甲狀腺的甲狀腺組織等。降低：甲減，低TBG血癥（腎病綜合征，慢性肝病，蛋白丟失性腸病，遺傳性低TBG血癥等），全垂體功能減退癥，下丘腦病變，劇烈活動等。3．游離三碘甲腺原氨酸(FT3)/游離甲狀腺素（FT4）FT3、FT4是T3、T4的生理活性形式，是甲狀腺代謝狀態(tài)的真實反映，F(xiàn)T3、FT4比T3、T4更靈敏，更有意義。FT3、FT4測定的優(yōu)點是不受其結(jié)合蛋白質(zhì)濃度和結(jié)合特性變化的影響，因此不需要另外測定結(jié)合參數(shù)。FT3含量對鑒別診斷甲狀腺功能是否正常、亢進或低下有重要意義，對甲亢的診斷很敏感，是診斷T3型甲亢的特異性指標。FT4測定是臨床常規(guī)診斷的重要部分，可作為甲狀腺的監(jiān)測手段。當懷疑甲狀腺功能紊亂時，F(xiàn)T4和TSH常常一起測定。TSH、FT3和FT4三項聯(lián)檢，常用以確認甲亢或甲低，以及追蹤療效。甲狀腺檢測方法常見的甲狀腺的檢測方法有全自動化學發(fā)光免疫法(CLIA)和同位素稀釋液相色譜串聯(lián)質(zhì)譜法(ID-LC/MS/MS)，現(xiàn)有的免疫分析方法快速、靈敏。熙寧生物通過Jurkat細胞檢測報告基因luciferase的表達，檢測化學發(fā)光信號值，結(jié)果顯示正相關(guān)。</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="山東是什么大分子生物分析平臺,大分子生物分析平臺" src="https://tyunfile.71360.com/WaterMark/UploadFile/Accurantbio/637413936861353232/1422789.png"></div><p> 2019年2月25日，國家藥品監(jiān)督管理局網(wǎng)站宣布，復(fù)星醫(yī)藥旗下公司—復(fù)宏漢霖研制開發(fā)的較早國產(chǎn)生物類似藥——利妥昔單抗注射液（商品名：漢利康）獲批上市，這意味著我國將打破羅氏原研藥壟斷，國產(chǎn)生物類似藥進去了一個新的時代。一時間，醫(yī)藥行業(yè)和投資領(lǐng)域再次將目光投向了近年來的“新寵”——大分子生物藥。近幾年，大分子生物藥憑借驚人的效果成為制藥行業(yè)近年來發(fā)展更快的行業(yè)之一，全球藥品種，有8個都是大分子生物藥，一款阿達木單抗的銷售額就高達199億美元，而且隨著生物在抗領(lǐng)域的效果凸顯，其市場前景將遠超我們的想象，抗及自身免疫疾病領(lǐng)域的生物藥是未來10年持續(xù)研發(fā)的熱點。國內(nèi)生物藥增長速度更是超越全球市場，尤其是生物藥中的單抗類藥物，據(jù)預(yù)測未來三年將以，作為擁有13億人口、GDP排名第二的大國，中國未來對生物藥的需求是巨大，而且2017年入選中國國家醫(yī)保談判目錄的44個藥品中有14個為生物藥，隨著國家醫(yī)保政策的推進，大分子生物藥依然到了爆發(fā)的前夜！從投資的角度來講，如此大的賽道無疑提供了長長的坡，投資其中抓住歷史大機遇定會獲得遠超社會平均收益率的回報。我們也堅定的認為：未來三年是國產(chǎn)生物藥爆發(fā)的三年。游離藥物(free drug)檢測和總藥物(Total drug)檢測的目的是更真實測定出血液樣品中能否發(fā)揮活性作用的藥物。山東是什么大分子生物分析平臺</p><p style="text-indent:25px">熙寧生物創(chuàng)始人曾參與《中國藥典2015版》“生物樣品分析方法驗證指導原則”；山東是什么大分子生物分析平臺</p><p style="text-indent:25px">“大分子、高分子、多聚物”三個詞匯都有不同程度的混淆或混同，給理解造成一定的困難。4生物大分子的定義"生物大分子”對應(yīng)的英文詞為“biomacromole-cule"，可以理解為由生物體產(chǎn)生或制造的有機大分子，并不一定是多聚物。同時，生物大分子不都是由單一的單體重復(fù)聚合而成的復(fù)合物（如常見的核苷酸有4種，氨基酸有20多種）且它們或多或少都有其他物質(zhì)的加入（如蛋白上有糖、核苷酸上有磷等）。有詞典提岀：“生物大分子是指蛋白質(zhì)、核酸等物質(zhì)，是一種或多種小分子物質(zhì)如單糖、氨基酸、核苷酸靠共價鍵連接而成的聚合體”。一般認為，蛋白質(zhì)分子應(yīng)由50個以上的氨基酸殘基組成，部分蛋白質(zhì)還有多條肽鏈，相對分子質(zhì)量大約為5000到幾百萬，已知小的天然蛋白質(zhì)是胰島素，相對分子質(zhì)量達5733，由51個氨基酸組成。核酸是由50個以上核苷酸組成多聚核苷酸，以核苷酸的平均相對分子質(zhì)量330計算，則核酸的相對分子質(zhì)量大于16000。多糖是由20個以上單糖聚合成的糖類，各種多糖的分子量從幾萬到幾百萬不等。結(jié)構(gòu)生物學指出，一個生物大分子，無論是核酸、蛋白質(zhì)或多糖，在發(fā)揮生物學功能時，必須具有特定的空間結(jié)構(gòu)（三維結(jié)構(gòu)）。山東是什么大分子生物分析平臺</p><p style="text-indent:25px">寧波熙寧檢測技術(shù)有限公司致力于醫(yī)藥健康，是一家服務(wù)型的公司。公司業(yè)務(wù)涵蓋生物分析，臨床檢測，生物藥檢測，免疫原性檢測等，價格合理，品質(zhì)有保證。公司秉持誠信為本的經(jīng)營理念，在醫(yī)藥健康深耕多年，以技術(shù)為先導，以自主產(chǎn)品為重點，發(fā)揮人才優(yōu)勢，打造醫(yī)藥健康良好品牌。寧波熙寧檢測技術(shù)秉承“客戶為尊、服務(wù)為榮、創(chuàng)意為先、技術(shù)為實”的經(jīng)營理念，全力打造公司的重點競爭力。</p></p><br /><p>文章來源地址: 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