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clearfix"><h1>江蘇按需求大分子生物分析平臺寧波熙寧檢測技術(shù)供應(yīng)</h1><div id="3fhb8h4" class="proBig"><div id="4f7lifc" class="bigimg"><div><p class="pic"><img src="https://tyunfile.71360.com/WaterMark/UploadFile/Accurantbio/637413936533023111/2485964.png" class="vcenter" onerror="javascript:this.src='/static/new_net_01/images/nopic.jpg';"></p></div></div><div id="pt78tly" class="smallimg"><div><p class="pic"><img src="https://tyunfile.71360.com/WaterMark/UploadFile/Accurantbio/637413936533023111/2485964.png" class="vcenter" onerror="javascript:this.src='/static/new_net_01/images/nopic.jpg';"></p></div></div></div><div id="qp94tqx" class="content"><p><span>需求數(shù)量：</span>0</p><p><span>價格要求：</span>面議</p><p><span>所在地：</span>上海市</p><p><span>包裝要求：</span><span style="color: #f30;"></span></p><p><span>產(chǎn)品關(guān)鍵詞：</span>江蘇按需求大分子生物分析平臺,大分子生物分析平臺</p><p><span>***更新：</span>2021-02-07 02:06:20</p><p><span id="click" >瀏覽次數(shù)：6次</span></p><a rel="nofollow" class="button">聯(lián)系我們</a></div></div><div id="adsuwdf" class="rightbox"><h3>公司基本資料信息</h3><p style="border:0;"><a rel="nofollow">寧波熙寧檢測技術(shù)有限公司</a></p><p><span>聯(lián)系人：</span>王蒙</p><p><span>郵箱: </span>meng.wang@accurantbio.com</p><p><span>電話: </span>13585708897</p><p><span>傳真: </span>0574_</p><p><span>網(wǎng)址: </span>https://www.accurantbio.com</p><p><span>手機: </span>0574-87878487</p><p><span>地址: </span>浙江省寧波市鄞州區(qū)聚賢路587弄A5幢4樓</p><p>[當(dāng)前離線] <a rel="nofollow"> [加為商友] </a><a rel="nofollow"> [發(fā)送信件] </a></p></div></div><div id="8ztvxeg" class="page-proshow02"><p class="title">詳細(xì)說明</p><div id="clk8xul" class="box"><p><p style="text-indent:25px">在生物類似藥和原研藥之間使用不同的PK分析方法會增加生物分析計劃和數(shù)據(jù)解釋的復(fù)雜性?？紤]到實際操作的便利性，優(yōu)先方法是使用一個藥物作為公用的參考標(biāo)準(zhǔn)（標(biāo)準(zhǔn)品）來判斷生物類似藥和原研藥濃度水平。這也是當(dāng)前業(yè)界公認(rèn)的推薦做法，江蘇按需求大分子生物分析平臺，即用一種PK分析方法進行生物類似藥和原研藥的檢測。所以生物類似藥和原研藥的PK評價的首要目的就是證明兩種藥物的濃度-響應(yīng)值關(guān)系是相似的。通常在方法開發(fā)階段建立一種通用型的配體結(jié)合分析方法（ligand binding assay，江蘇按需求大分子生物分析平臺, LBA），以能夠同時用于生物類似藥和原研藥的分析。然后在方法驗證階段證明分析方法可以對兩種藥物進行同等的定量檢測。在藥物的CMC階段已經(jīng)產(chǎn)生了大量的數(shù)據(jù)來支持生物類似藥和原研藥的結(jié)構(gòu)相似性，因此，江蘇按需求大分子生物分析平臺，兩種藥物在LBA分析中很大程度上會表現(xiàn)出相似的結(jié)果。熙寧生物是一家具有豐富經(jīng)驗的大分子生物檢測公司，支持PK、ADA、NAb、CAR-T等檢測。Blinatumomab由兩個ScFv組成，缺少正?？贵w的Fc端，無法通過Fc介導(dǎo)的FcRn內(nèi)吞作用來延長半衰期。江蘇按需求大分子生物分析平臺</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="江蘇按需求大分子生物分析平臺,大分子生物分析平臺" src="https://tyunfile.71360.com/WaterMark/UploadFile/Accurantbio/637413936533023111/2485964.png"></div><p style="text-indent:25px">2014年前，國產(chǎn)流式細(xì)胞儀基本還是空白，產(chǎn)品全部依賴進口。根據(jù)中國海關(guān)數(shù)據(jù)，2014年中國流式細(xì)胞儀的裝機量為971臺，銷售額約為。中國雖然起步較晚，但增長極快，2017年中國流式細(xì)胞分析市場將達(dá)到，自然增長速度達(dá)30%左右，幾乎是中國IVD市場增長速度（15%）的2倍。流式細(xì)胞儀的原理和構(gòu)造流式細(xì)胞儀主要由四部分組成；流動室和液流系統(tǒng)；激光源和光學(xué)系統(tǒng)；光電管和檢測系統(tǒng)；計算機和分析系統(tǒng)，其中流動室和液流系統(tǒng)是儀器的部件。1.流動室和液流系統(tǒng)：流動室由樣品管、鞘液管和噴嘴等組成，常用光學(xué)玻璃、石英等透明、穩(wěn)定的材料，其設(shè)計和制作均很精細(xì)，是液流系統(tǒng)的心臟。2.激光器和光學(xué)系統(tǒng)：光源主要根據(jù)被激發(fā)物質(zhì)的激發(fā)光譜而定，常用的光源有激光器和弧光燈。激光器以氬離子激光器為普遍，也配有氪離子激光器或染料激光器。氬離子激光器的發(fā)射光譜中，綠光514nm和藍(lán)光488nm的譜線強，約占總光強的80%；氪離子激光器光譜多集中在可見光部分，以647nm較強；免疫學(xué)上使用的一些熒光染料激發(fā)光波長在550nm以上，可使用染料激光器。汞燈是**常用的弧光燈，其發(fā)射光譜大部分集中于300-400nm，適合需要用紫外光激發(fā)的場合。江蘇按需求大分子生物分析平臺生物大分子藥物具有相對分子質(zhì)量大、不易透過生物膜、給藥劑量低、易在體內(nèi)降解等特點。精翰生物專注檢測。</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="江蘇按需求大分子生物分析平臺,大分子生物分析平臺" src="https://tyunfile.71360.com/WaterMark/UploadFile/Accurantbio/637413936716148201/8598649.png"></div><p style="text-indent:25px">隨著人類基因組計劃的完成，人們意識到基因的數(shù)量遠(yuǎn)遠(yuǎn)無法解釋生命的復(fù)雜性和多樣性。作為生命活動的基本元件，蛋白質(zhì)、核酸、糖脂等生物大分子的動態(tài)化學(xué)修飾成為生命多樣性和復(fù)雜性的物質(zhì)基礎(chǔ)，貫穿了細(xì)胞命運決定、性狀調(diào)控以及個體發(fā)育等一系列重要的生命活動。對生物大分子動態(tài)修飾的研究與調(diào)控逐漸成為當(dāng)前生命科學(xué)領(lǐng)域受關(guān)注的領(lǐng)域之一，也成為化學(xué)與生命科學(xué)以及醫(yī)學(xué)交叉界面為活躍的研究前沿。國家自然科學(xué)基金會于2017年啟動了“生物大分子動態(tài)修飾與化學(xué)干預(yù)”重大研究計劃，旨在推動我國在該領(lǐng)域的發(fā)展，促進人們對生物大分子動態(tài)修飾機制的認(rèn)識和對其功能的調(diào)控干預(yù)。近日，該重大研究計劃的**組和秘書組在ScienceChinaLifeSciences（《中國科學(xué)：生命科學(xué)》英文版）發(fā)表了題為“DynamicModificationsofBiomacromolecules:MechanismandChemicalInterventions”的文章，系統(tǒng)介紹了該重大研究計劃的科學(xué)意義、研究部署和項目啟動后取得的突出進展。文章首先介紹了生物大分子動態(tài)修飾研究的背景與現(xiàn)狀，闡明深入研究生物大分子動態(tài)修飾的機制和功能是揭示新的生命過程、發(fā)現(xiàn)新的疾病診療手段的重要基礎(chǔ)，有著深遠(yuǎn)的科學(xué)意義和社會價值。</p><p style="text-indent:25px">色譜和質(zhì)譜技術(shù)在醫(yī)藥研究中扮演著越來越重要的角色，從早期研發(fā)、表征分析、工藝優(yōu)化到CMC、QC分析均有應(yīng)用。熙寧生物，致力于更好的生物質(zhì)譜檢測技術(shù)開發(fā)與應(yīng)用，從組學(xué)全覆蓋研究到單分子深入分析，逐步聚焦，只為實現(xiàn)更好的生物質(zhì)譜應(yīng)用；從科技服務(wù)到醫(yī)藥研究，打通機制研究到臨床應(yīng)用的全通路。熙寧生物以生物科技成就他人、造福大眾。圖1質(zhì)譜在科技服務(wù)和生物醫(yī)藥中的應(yīng)用我們所提供的的服務(wù)包括生物藥表征檢測（蛋白、多肽）、臨床前DMPK研究及生物分析。生物藥又稱為大分子藥，生物制品主要分為生物藥物和預(yù)防性生物藥物。預(yù)防性生物藥物主要指疫苗。生物藥物主要包括單克隆抗體、酶、干擾素、細(xì)胞因子和胰島素等。生物藥表征檢測服務(wù)在蛋白研究中，指的是蛋白質(zhì)的各項特性，包括結(jié)構(gòu)、理化、活性等一系列內(nèi)容。準(zhǔn)確的氨基酸序列、分子量、價態(tài)變化、糖基化、聚集水平以及氧化水平都是蛋白質(zhì)藥物表征的關(guān)鍵要素。具體服務(wù)項目如下1.純度、肽圖分析（HPLC）采用高效液相色譜法對蛋白多肽的純度和肽圖譜進行分析，從而實現(xiàn)對蛋白質(zhì)純度和酶解后肽段分布情況的測定，對于蛋白多肽類藥物的進一步研究具有重要意義。純度可用于工業(yè)蛋白多肽樣品雜質(zhì)與含量分析。精翰生物流式項目團隊，多個項目經(jīng)驗，已與多家臨床研究中心（醫(yī)院）合作，提供全血分離PBMC整套解決方案。</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="江蘇按需求大分子生物分析平臺,大分子生物分析平臺" src="https://tyunfile.71360.com/WaterMark/UploadFile/Accurantbio/637413936812749716/4530416.png"></div><p style="text-indent:25px">染色體分析染色體分析直接檢測染色體數(shù)目及結(jié)構(gòu)的異常，而不是檢查某條染色體上某個基因的突變或異常。通常用來診斷胎兒的異常。常見的染色體異常是多一條染色體，檢測用的細(xì)胞來自血液樣本，若是胎兒，則通過羊膜穿刺或絨毛膜絨毛取樣獲得細(xì)胞。將之染色，讓染色體凸顯出來，然后用高倍顯微鏡觀察是否有異常。DNA分析主要用于識刖單個基因異常引發(fā)的遺傳性疾病，如亨廷頓病等。DNA分析的細(xì)胞來自血液或胎兒細(xì)胞。基因檢測的分類基因檢測可以分為：基因篩檢主要是針對特定團體或全體人群進行檢測。大多數(shù)通過產(chǎn)前或新生兒的基因檢測以達(dá)到篩檢的目的。生殖性基因檢測在進行體外人工授精階段可運用，篩檢出胚胎是否帶有基因變異，避免胎兒患有遺傳性疾病。診斷性檢測多數(shù)用來協(xié)助臨床用藥指導(dǎo)。基因攜帶檢測基因攜帶者如果與某些特殊基因相結(jié)合，可能會導(dǎo)致下一代患基因疾病，通過基因攜帶者的檢測可篩檢出此種可能，作為基因攜帶者婚前檢查、生育時的參考。癥狀出現(xiàn)前的檢測檢測目的是了解目前健康良好者是否帶有某種突變基因，而此基因與特定疾病的發(fā)生有密切的聯(lián)系。基因檢測的臨床意義是用于疾病的診斷。熙寧生物專注于大分子生物檢測。熙寧生物主要檢測內(nèi)容包含藥代動力學(xué)(PK)，藥效動力學(xué)(PD)，抗藥抗體(ADA)，中和抗體(NAb)。江蘇按需求大分子生物分析平臺</p><p style="text-indent:25px">熙寧生物致力于發(fā)展臨床大分子生物檢測，經(jīng)驗豐富。江蘇按需求大分子生物分析平臺</p><p> 流式細(xì)胞術(shù)（FCM）檢測MRD的原理是通過分析細(xì)胞表面或胞內(nèi)一系列抗原的表達(dá)模式（如圖一）來識別只在白血病細(xì)胞中出現(xiàn)而正常骨髓中不存在或存在比例極低的免疫表型，即“白血病相關(guān)免疫表型”(1eukemia-associated immunophenotypes，LAIP)。根據(jù)抗原表達(dá)特點將LAIP分為以下幾種表現(xiàn)形式：跨系抗原表達(dá)、非同步抗原表達(dá)、抗原表達(dá)量異常、散射光信號異常以及表達(dá)少數(shù)白血病特異性抗原?？缦悼乖侵改骋幌盗械募?xì)胞表達(dá)其他系列的抗原，如B-ALL的白血病細(xì)胞中表達(dá)髓系抗原CD66C、CDl3、CD33等；非同步抗原表達(dá)是指應(yīng)該分別出現(xiàn)在分化早期和晚期的抗原同時出現(xiàn)，如AML中CDllb(晚期)和CD34(早期)共表達(dá)；抗原表達(dá)量異常指與同系列、相同分化階段的正常造血細(xì)胞比較，白血病細(xì)胞中某些抗原的表達(dá)強度明顯異常，包括減低(low expression，low)、缺失或升高(bright expression，bri)，如正常CDl9+CD34+B系原始淋巴細(xì)胞應(yīng)該高表達(dá)CD38，B-ALL中白血病細(xì)胞則低表達(dá)甚至不表達(dá)CD38。寧波熙寧檢測技術(shù)有限公司（AccurantBioTech Inc）是一家專業(yè)的符合國際GLP質(zhì)量標(biāo)準(zhǔn)的生物分析實驗室，可以為您提供注冊性臨床和臨床前流式細(xì)胞分析的一站式服務(wù)。江蘇按需求大分子生物分析平臺</p><p style="text-indent:25px">寧波熙寧檢測技術(shù)有限公司是一家一般項目：技術(shù)服務(wù)、技術(shù)開發(fā)、技術(shù)咨詢、技術(shù)交流、技術(shù)轉(zhuǎn)讓、技術(shù)推廣；醫(yī)學(xué)研究和試驗發(fā)展；實驗分析儀器銷售；儀器儀表銷售（除依法須經(jīng)批準(zhǔn)的項目外，憑營業(yè)執(zhí)照依法自主開展經(jīng)營活動）。許可項目：貨物進出口，技術(shù)進出口，進出口代理（依法須經(jīng)批準(zhǔn)的項目，經(jīng)相關(guān)部門批準(zhǔn)后方可開展經(jīng)營活動，具體經(jīng)營項目以審批結(jié)果為準(zhǔn)）。的公司，致力于發(fā)展為創(chuàng)新務(wù)實、誠實可信的企業(yè)。寧波熙寧檢測技術(shù)擁有一支經(jīng)驗豐富、技術(shù)創(chuàng)新的專業(yè)研發(fā)團隊，以高度的專注和執(zhí)著為客戶提供生物分析，臨床檢測，生物藥檢測，免疫原性檢測。寧波熙寧檢測技術(shù)致力于把技術(shù)上的創(chuàng)新展現(xiàn)成對用戶產(chǎn)品上的貼心，為用戶帶來良好體驗。寧波熙寧檢測技術(shù)始終關(guān)注醫(yī)藥健康市場，以敏銳的市場洞察力，實現(xiàn)與客戶的成長共贏。</p></p><br /><p>文章來源地址: http://www.cdcfah.com/cp/3197911.html</p></div></div></div></div></div><div id="koogs2r" class="page-right twoColRt"><div id="gac3ryv" class="box01 margin10 clearfix"><h3><a href="http://www.cdcfah.com/cp/">猜你喜歡</a></h3><div id="bvxz27s" class="recomPic likePro"><a href="http://www.cdcfah.com/cp/814588.html"><div><img 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