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class="content"><p><span>需求數(shù)量：</span>0</p><p><span>價(jià)格要求：</span>面議</p><p><span>所在地：</span>上海市</p><p><span>包裝要求：</span><span style="color: #f30;"></span></p><p><span>產(chǎn)品關(guān)鍵詞：</span>N-雜環(huán)卡賓相關(guān)哌啶化合物,哌啶</p><p><span>***更新：</span>2021-01-11 01:16:45</p><p><span id="click" >瀏覽次數(shù)：0次</span></p><a rel="nofollow" class="button">聯(lián)系我們</a></div></div><div id="ycjbyan" class="rightbox"><h3>公司基本資料信息</h3><p style="border:0;"><a rel="nofollow">上海畢得醫(yī)藥科技有限公司</a></p><p><span>聯(lián)系人：</span>邱鴻婷</p><p><span>郵箱: </span>3003495196@qq.com</p><p><span>電話: </span>13818398014</p><p><span>傳真: </span>021_</p><p><span>網(wǎng)址: </span>https://www.bidepharm.com</p><p><span>手機(jī): </span>021-61629020</p><p><span>地址: </span>翔殷路128號(hào)11號(hào)樓A座101室</p><p>[當(dāng)前離線] <a rel="nofollow"> [加為商友] </a><a rel="nofollow"> [發(fā)送信件] </a></p></div></div><div id="kace22v" class="page-proshow02"><p class="title">詳細(xì)說明</p><div id="pjgi3tv" class="box"><p><p style="text-indent:25px">含有1,3,4-惡二唑，1,2,4-惡二唑和1,2,4-三唑環(huán)系統(tǒng)的對(duì)映體雜環(huán)Boc保護(hù)的Phe-Gly二肽模擬物是偽肽合成中的結(jié)構(gòu)單元。三個(gè)衍生物（1-3）具有直接鍵合到雜環(huán)上的羧酸官能團(tuán)，并且三個(gè)衍生物（4-6）在雜環(huán)和酸官能團(tuán)之間具有額外的亞甲基，以提高構(gòu)象柔韌性。該模擬物被用作生物活性肽dermorphin（Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2）和物質(zhì)P（Arg-Pro-Lys-Pro-Gln-Gln-Phe）中的Phe Gly替代品-Phe-Gly-Leu-MetNH（2），N-雜環(huán)卡賓相關(guān)哌啶化合物，SP）。使用Boc化學(xué)方法在MBHA-樹脂上使用固相方法進(jìn)行偽肽合成。通過測(cè)試dermorphin假肽的μ阿片和δ阿片受體親和力以及SP假肽的NK1受體親和力來(lái)進(jìn)行生物學(xué)評(píng)估。結(jié)果表明，除3個(gè)模擬物外，N-雜環(huán)卡賓相關(guān)哌啶化合物，所有模擬物都是dermorphin中Phe-Gly的替代品，因?yàn)樗鼈儗?duì)mu受體的親和力（IC50 = 12-31 nM）與dermorphin本身的親和力相同（IC50 = 6.2 nM），N-雜環(huán)卡賓相關(guān)哌啶化合物。還評(píng)估了三種假肽對(duì)人mu受體的激動(dòng)活性。結(jié)果表明，所測(cè)試的化合物保留了其激動(dòng)劑活性。該雜環(huán)胺由包含五個(gè)亞甲基橋和一個(gè)胺橋的六元環(huán)組成。N-雜環(huán)卡賓相關(guān)哌啶化合物</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="N-雜環(huán)卡賓相關(guān)哌啶化合物,哌啶" src="https://tyunfile.71360.com/WaterMark/UploadFile/shbdyykj/637439115867680637/3418900.png"></div><p style="text-indent:25px">共價(jià)有機(jī)骨架構(gòu)成聚合材料的子類，可提供更高的孔隙率，功能性和穩(wěn)定性。在這項(xiàng)工作中，提出了一種基于聯(lián)吡啶結(jié)構(gòu)單元的共價(jià)三嗪骨架，并闡明了其局部結(jié)構(gòu)，孔隙率和金屬吸收能力。使用ZnCl2作為路易斯酸性三聚催化劑，在電熱條件下于400-700攝氏度下進(jìn)行典型的合成。在400℃的合成溫度下，可以確定高度的局部有序性以及三嗪和聯(lián)吡啶部分的存在，以及微孔和比表面積大至1100 m（2）g（-1）。中孔在高于450攝氏度的合成溫度下越來(lái)越多地形成，產(chǎn)生高度多孔的框架，具有分層的孔隙率，并且在700攝氏度時(shí)具有超大的表面積，超過3200 m（2）g（-1）。研究人員證明了聯(lián)吡啶單元的功能為包括Co，Ni，Pt和Pd在內(nèi)的多種過渡金屬離子提供特異且牢固的結(jié)合位點(diǎn)。金屬負(fù)載的程度（高之38 wt％）可以通過溶液中的金屬濃度進(jìn)行調(diào)節(jié)，并且取決于金屬的類型以及CTF的合成溫度。特定于位點(diǎn)的金屬配位的證據(jù)預(yù)示著將負(fù)載金屬的CTF用作帶有均相型活性位點(diǎn)的非均相催化劑的用途。手性氨基膦哌啶相關(guān)產(chǎn)品烯胺酮作為雜環(huán)合成的砌塊：煙酸和噻吩吡啶衍生物的新合成。</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="N-雜環(huán)卡賓相關(guān)哌啶化合物,哌啶" src="https://tyunfile.71360.com/WaterMark/UploadFile/shbdyykj/637439115825239454/6107741.png"></div><p style="text-indent:25px">哌啶是含有一個(gè)N原子的六元環(huán)，可以認(rèn)為是吡啶和氫的反應(yīng)產(chǎn)物。一些哌啶化合物及其衍生物具有良好的生物學(xué)活性，例如殺蟲，殺菌，除草和抗植物病毒活性。其中一些化合物用于農(nóng)藥，藥物，染料和其他精細(xì)化工行業(yè)。在醫(yī)學(xué)領(lǐng)域，哌啶基是天然產(chǎn)物生物堿的一種成分，例如止痛藥哌替啶；在農(nóng)藥領(lǐng)域，例如地美哌酸鹽和胡椒粉已被***用于防治稻田中的n和洋蘭。）和煙堿殺蟲劑哌啶在我國(guó)制造。目前，關(guān)于國(guó)內(nèi)外哌啶類化合物的總體情況尚無(wú)報(bào)道。</p><p style="text-indent:25px">使2-芳基肼基-3-氧代丁腈2與鹽酸羥胺反應(yīng)，得到酰胺肟3。在乙酸酐中回流時(shí)，將其環(huán)化成相應(yīng)的惡二唑4。當(dāng)在哌啶存在下在DMF中回流時(shí)，形成相應(yīng)的1,2,3-三唑胺5。通過加入乙酸酐將后者?；癁?，同時(shí)用丙二腈處理5，得到1,2,3-三唑并[4,5-b]吡啶8。用DMFDMA處理乙?；苌?，得到烯胺酮9。烯胺酮9 將其與氯化苯重氮鎓偶合，得到苯基偶氮-1,2,3-三唑并[4,5-b]吡啶10。嘗試通過在AcOH中回流將化合物14轉(zhuǎn)化為1,2,3-三唑并[4,5-d]嘧啶15。 / NH4OAc失敗。相反，形成了水解產(chǎn)物5。N-雜環(huán)碳烯催化的硝基烯烴反應(yīng)：合成重要的結(jié)構(gòu)單元。</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="N-雜環(huán)卡賓相關(guān)哌啶化合物,哌啶" src="https://tyunfile.71360.com/WaterMark/UploadFile/shbdyykj/637439115881254773/2914049.png"></div><p style="text-indent:25px">為了追求單組分有機(jī)半導(dǎo)體和金屬的封閉殼砌塊，研究人員制備了苯并喹啉-1,2,3-噻唑苯唑Qs，一種雜環(huán)硒的兩性而隙其高占用和低未占用的分子軌道之間。在固態(tài)中，QS存在于兩個(gè)結(jié)晶相和一個(gè)納米晶相中。通過在環(huán)境溫度下的高分辨率粉末X射線衍射方法和升高的壓力（0-15GPa），已經(jīng)通過高分辨率粉末X射線衍射方法確定了結(jié)晶相（空間組R3C和P2（1）/ c）的結(jié)構(gòu)，并且它們的晶體包裝模式已經(jīng)存在與相關(guān)的全硫磺雙層苯醌-1,2,3-二唑QT（空間組CMC2（1））相比?；赟E和SE和SE和SE和SE的材料之間的結(jié)構(gòu)差異在局部分子間S / SE ... N'/ O'二次鍵合相互作用方面解釋，其強(qiáng)度隨硫芥性的性質(zhì)而變化（S vs SE）。雖然沒有找到與CMC2（1）相位相關(guān)的QT相關(guān)的完全二維磚墻填充圖案，但是QS的所有三個(gè)階段都是小的帶隙半導(dǎo)體，Sigma（RT）范圍為10（-5 ）對(duì)于R3C相的P2（1）/ C期至10（-3）Scm（-??1）的Scm（-??1）。施加壓力的化合價(jià)和導(dǎo)通帶的帶寬增加，導(dǎo)致導(dǎo)電性的增加和熱activation能量E-Act的降低。區(qū)域選擇性非對(duì)映異構(gòu)體邁克爾加合物作為雜環(huán)合成中的砌塊。手性膦哌啶</p><p style="text-indent:25px">LiAlh4誘導(dǎo)的選擇性環(huán)吡啶朝向2-（氨基甲基）吡咯烷和3-氨基哌啶作為符合條件的雜環(huán)砌塊。N-雜環(huán)卡賓相關(guān)哌啶化合物</p><p style="text-indent:25px">β-內(nèi)酰胺是適合于制備各種含氮目標(biāo)化合物的柔性構(gòu)件。在研究中，對(duì)以往被忽視的4-鹵烷基-內(nèi)酰胺的合成勢(shì)進(jìn)行了詳細(xì)的闡述，重點(diǎn)介紹了不同的單環(huán)雜環(huán)和雙環(huán)雜環(huán)的制備。第一種方法是通過中間偶氮環(huán)或偶氮環(huán)離子將這些鹵化的構(gòu)件環(huán)轉(zhuǎn)變成立體定界的偶氮環(huán)、偶氮環(huán)、吡咯環(huán)和哌啶。在第二部分中，通過自由基或離子環(huán)化協(xié)議，開發(fā)了1,4-和3,4-融合雙環(huán)β-內(nèi)酰胺的新的和立體選擇性條目。此外，鹵代β-內(nèi)酰胺的環(huán)擴(kuò)展為官能團(tuán)化的單環(huán)和雙環(huán)吡咯烷-2-酮，作為環(huán)丁基甲基carbenium離子到環(huán)戊基carbenium離子重排的aza-類似物。詳細(xì)闡述了疊氮烷-2-酮和環(huán)轉(zhuǎn)化產(chǎn)物的手性反應(yīng)，包括3(S)-烷氧基-4(S)-[1(S)-氯乙基]疊氮烷-2-酮的合成，以及與哌嗪類、morphine 類和重氮烷類環(huán)化的雙環(huán)β-內(nèi)酰胺的制備。N-雜環(huán)卡賓相關(guān)哌啶化合物</p><p> 上海畢得醫(yī)藥科技有限公司成立于2007年，總部位于上海市楊浦區(qū)理工大學(xué)國(guó)家大學(xué)科技園，是一家以醫(yī)藥中間體相關(guān)產(chǎn)品的研發(fā)、生產(chǎn)、銷售及合成定制為主的****。自公司成立以來(lái)，始終堅(jiān)持信譽(yù)至上，質(zhì)量過硬的企業(yè)信條，產(chǎn)品被應(yīng)用于生命科學(xué)、有機(jī)化學(xué)、材料科學(xué)、分析化學(xué)與其他學(xué)科的研發(fā)及生產(chǎn)領(lǐng)域，銷售范圍遍及全球。目前，公司與諸多國(guó)內(nèi)**醫(yī)藥研發(fā)單位建立了合作伙伴關(guān)系。 </p> <p> 公司位于上海理工大學(xué)科技園的行政辦公中心面積達(dá)1,700平米，在藥谷設(shè)立的研發(fā)中心面積1,800平米，包括化學(xué)合成實(shí)驗(yàn)室和公斤級(jí)實(shí)驗(yàn)室，并配有現(xiàn)代化倉(cāng)儲(chǔ)物流中心。公司優(yōu)勢(shì)產(chǎn)品包括特色雜環(huán)化合物、含氟化合物、手性化合物、氨基酸及其衍生物、硼酸及其衍生物等，已有多項(xiàng)科研項(xiàng)目獲得國(guó)家發(fā)明專利。 </p> <p> 為確保產(chǎn)品質(zhì)量，公司引進(jìn)了先進(jìn)齊全的分析測(cè)試設(shè)備，包括400MHz核磁共振儀(NMR)、電感耦合等離子體發(fā)射光譜儀(ICP)、液質(zhì)聯(lián)用儀(LCMS)等，并配以嚴(yán)格的質(zhì)量管理體系。公司簽有具備GMP資質(zhì)的合作工廠，配備專業(yè)的研發(fā)團(tuán)隊(duì)，形成了從小試、中試到工業(yè)化規(guī)模的生產(chǎn)能力，滿足客戶定制合成、目錄試劑采購(gòu)及合成外包生產(chǎn)的需求。 </p></p><br /><p>文章來(lái)源地址: http://www.cdcfah.com/cp/2790290.html</p></div></div></div></div></div><div id="bczwoac" class="page-right twoColRt"><div id="dnkceg7" class="box01 margin10 clearfix"><h3><a href="http://www.cdcfah.com/cp/">猜你喜歡</a></h3><div id="lfmjml8" class="recomPic likePro"><a href="http://www.cdcfah.com/cp/814588.html"><div><img src="http://tyunfile.71360.com/UpLoadFile/2019/11/1/14/637082168864691056_lgpj_5374157.jpg" alt="福建ZF配件哪家強(qiáng) 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