手性亞磷酰胺哌啶合成方法上海畢得醫(yī)藥科技供應(yīng)-b2b網(wǎng)站_b2b電子商務(wù)平臺(tái)【買產(chǎn)品】-上?？谄蚴称酚邢薰?/title><meta name="description" content="提出了一種全合成擬蝶呤和相關(guān)擬蝶烷的逆合成策略。該方案取決于合適的2，5-二官能化的3-糠酸酯的早期加工。為此，一對(duì)有用的底物21和24易于由2，3-O-異亞丙基-D-甘油醛和4-（苯硫基）乙酰乙酸甲酯合成。接下來研究這兩種中間體向呋喃內(nèi)酯"><meta name="keywords" content="手性亞磷酰胺哌啶合成方法,哌啶"><link rel="canonical" href="http://www.cdcfah.com/"/><meta name="applicable-device" content="pc"><link rel="shortcut icon" href="/static/new_net_01/images/favicon.ico"><link rel="stylesheet" href="/static/new_net_01/css/slick.css" /><link rel="stylesheet" href="/static/new_net_01/css/addnew.css"><link rel="stylesheet" href="/static/new_net_01/css/sidenav.css"><link rel="stylesheet" href="/static/new_net_01/css/style.css" /><link rel="stylesheet" href="/static/new_net_01/css/tab.css"><link rel="stylesheet" href="/static/new_net_01/css/404.css"> <meta name="baidu-site-verification" content="OBVzrC9aaQ" /> <meta http-equiv="Cache-Control" content="no-transform" /> <meta 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href="http://www.cdcfah.com/cp/third-jxhxp_ylykq/">原料藥</a>?手性亞磷酰胺哌啶合成方法上海畢得醫(yī)藥科技供應(yīng)</p><div id="kygajo8" class="leftbox clearfix"><h1>手性亞磷酰胺哌啶合成方法上海畢得醫(yī)藥科技供應(yīng)</h1><div id="ar8d905" class="proBig"><div id="7c6ddev" class="bigimg"><div><p class="pic"><img src="https://tyunfile.71360.com/WaterMark/UploadFile/shbdyykj/637439115872748982/9990792.png" class="vcenter" onerror="javascript:this.src='/static/new_net_01/images/nopic.jpg';"></p></div></div><div id="xlizfjd" class="smallimg"><div><p class="pic"><img src="https://tyunfile.71360.com/WaterMark/UploadFile/shbdyykj/637439115872748982/9990792.png" class="vcenter" onerror="javascript:this.src='/static/new_net_01/images/nopic.jpg';"></p></div></div></div><div id="2qjouf0" class="content"><p><span>需求數(shù)量：</span>0</p><p><span>價(jià)格要求：</span>面議</p><p><span>所在地：</span>上海市</p><p><span>包裝要求：</span><span style="color: #f30;"></span></p><p><span>產(chǎn)品關(guān)鍵詞：</span>手性亞磷酰胺哌啶合成方法,哌啶</p><p><span>***更新：</span>2021-01-16 00:23:42</p><p><span id="click" >瀏覽次數(shù)：2次</span></p><a rel="nofollow" class="button">聯(lián)系我們</a></div></div><div id="atjh1xv" class="rightbox"><h3>公司基本資料信息</h3><p style="border:0;"><a rel="nofollow">上海畢得醫(yī)藥科技有限公司</a></p><p><span>聯(lián)系人：</span>邱鴻婷</p><p><span>郵箱: </span>3003495196@qq.com</p><p><span>電話: </span>13818398014</p><p><span>傳真: </span>021_</p><p><span>網(wǎng)址: </span>https://www.bidepharm.com</p><p><span>手機(jī): </span>021-61629020</p><p><span>地址: </span>翔殷路128號(hào)11號(hào)樓A座101室</p><p>[當(dāng)前離線] <a rel="nofollow"> [加為商友] </a><a rel="nofollow"> [發(fā)送信件] </a></p></div></div><div id="i269nz8" class="page-proshow02"><p class="title">詳細(xì)說明</p><div id="0uy6nts" class="box"><p><p style="text-indent:25px">提出了一種全合成擬蝶呤和相關(guān)擬蝶烷的逆合成策略。該方案取決于合適的2，5-二官能化的3-糠酸酯的早期加工。為此，一對(duì)有用的底物21和24易于由2，3-O-異亞丙基-D-甘油醛和4-（苯硫基）乙酰乙酸甲酯合成。接下來研究這兩種中間體向呋喃內(nèi)酯27的轉(zhuǎn)化。獲得適當(dāng)控制立體化學(xué)的方法是在三氟化硼催化條件下將24與3-甲酰基丙酸甲酯縮合。接下來的五個(gè)步驟完成了27的（苯硫基）甲基取代基向所需的異戊烯基側(cè)鏈的轉(zhuǎn)化。因?yàn)?能以中等收率實(shí)現(xiàn)在46中內(nèi)酯羰基的烷基化-α，所以預(yù)期的大環(huán)的部分是通過較收斂的方式較早引入的。實(shí)際上，事實(shí)證明，手性亞磷酰胺哌啶合成方法，將24與52耦合是有效的并且具有非對(duì)映選擇性，手性亞磷酰胺哌啶合成方法。在精心設(shè)計(jì)丁烯醇內(nèi)酯亞基后引入異戊烯基側(cè)鏈的嘗試失敗后，化學(xué)順序被顛倒了。為此目的，用于兩個(gè)相關(guān)側(cè)基的氧化的雙亞硒基化策略特別有效。異丁烯基片段隨后在溴化物62上的化學(xué)特異性連接是通過鈀（0）催化偶聯(lián)至乙烯基錫烷的方法實(shí)現(xiàn)的，該方法具有相當(dāng)大的通用性。進(jìn)一步的化學(xué)操作產(chǎn)生了二十二碳四烯ane烷71，手性亞磷酰胺哌啶合成方法，從而完成了假p烷環(huán)系統(tǒng)的總合成的中間階段。該雜環(huán)胺由包含五個(gè)亞甲基橋和一個(gè)胺橋的六元環(huán)組成。手性亞磷酰胺哌啶合成方法</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="手性亞磷酰胺哌啶合成方法,哌啶" src="https://tyunfile.71360.com/WaterMark/UploadFile/shbdyykj/637439115872748982/9990792.png"></div><p style="text-indent:25px">由于部分氟化化合物作為藥物，農(nóng)藥，聚合物等的廣應(yīng)用，將三氟甲基選擇性引入有機(jī)分子變得越來越重要。除了開發(fā)高選擇性三氟甲基化劑外，開發(fā)三氟甲基取代的結(jié)構(gòu)單元也是一項(xiàng)挑戰(zhàn)。有機(jī)化學(xué)的任務(wù)。 3,3,3-三氟acetone酸鹽或相應(yīng)的水合物是用于合成三氟甲基取代的雜環(huán)的通用雙親電子結(jié)構(gòu)單元。與1，3-雙親核試劑（如脲，苯酚或苯胺）反應(yīng)可得到五元環(huán)。與1,4-雙親核試劑（氨基脲，氨基甲酰胺，鄰苯二胺）形成六元雜環(huán)。3,3,3-三氟acetone酸鹽與am的反應(yīng)可以高收率獲得4-羥基-4-三氟甲基-2-咪唑啉-5-酮。隨后用亞硫酰氯處理這些雜環(huán)得到4-氯-4-三氟甲基-2-咪唑啉-5-酮，其被證明是通用的三氟甲基取代的結(jié)構(gòu)單元。用多種雜原子和碳親核試劑取代氯化物是可行的。用重氮化合物擴(kuò)環(huán)得到三氟甲基取代的嘧啶。手性膦相關(guān)哌啶化合物價(jià)格哌啶是一種無色液體，具有令人討厭的氣味，是典型的胺類。</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="手性亞磷酰胺哌啶合成方法,哌啶" src="https://tyunfile.71360.com/WaterMark/UploadFile/shbdyykj/637439115895268337/1133578.png"></div><p style="text-indent:25px">研究了用親電子試劑活化磷烯烴的P 2 C鍵，作為制備和表征不尋常的有機(jī)磷化合物的方法。用HOTf（0.5當(dāng)量）處理RP？CHtBu（1？a：R = tBu; 1？b：R = 1-金剛烷基）得到二磷鎓鹽[RP？CHtBu？PR（CH2tBu）] OTf（[2？a] OTf和[2？b] OTf），每個(gè)都包含一個(gè)三元P2C環(huán)。相反，在1？a或1？b中添加MeOTf（0.5當(dāng)量）可得到二磷鎓鹽[RP？CHtBu？P（Me）R？CHtBu] OTf（[3？a] OTf和[3？b] OTf）包含四元P2C2雜環(huán)。在光譜上鑒定出三氟甲磺酸[[tBuP（CH2tBu）] OTf（[5？a] OTf）和三氟甲磺酸[[tBu（Me）P？CHtBu] OTf（[7？a] OTf）是形成[2]的中間體分別為[a] +和[3a] +?？梢杂?-丁炔捕獲三氟甲磺酸t(yī)rap中間體，得到磷鎓鹽[MeC 2 CMe 2 tBuPCH 2 tBu] OTf（[6αa] OTf）。用過量的MeOTf處理二磷鎓[3αa] OTf，得到[Me2P2CHtBu？PMetBu？CHtBu]（OTf）2（[4αa]（OTf）2）</p><p style="text-indent:25px">通過2-乙?；?3-甲基的反應(yīng)制備未報(bào)告的2- [E-3-（N，N-二甲基氨基）丙烯?；鵠 -3-甲基-5,6-二苯基咪唑并[2,1-b]噻唑3 -5，6-二苯基咪唑并[2，1-b]噻唑2與二甲基甲酰胺二甲基乙縮醛（DMF-DMA）。 Enaminone 3與腈亞胺5a-f進(jìn)行區(qū)域選擇性的1,3-偶極環(huán)加成反應(yīng)，得到相應(yīng)的吡唑7a-f。 7a，d，g與水合肼反應(yīng)，分別得到吡唑并[3，4-d]噠嗪8a-c。烯胺3也與肼，鹽酸羥胺，5-氨基吡唑11、6-氨基硫尿嘧啶15和馬尿酸22反應(yīng)。新合成的化合物的結(jié)構(gòu)通過光譜數(shù)據(jù)和元素分析得到證實(shí)。用作雜環(huán)合成中的結(jié)構(gòu)取代的烯胺：雜環(huán)合成中的砌塊：乙二甲?；陮?duì)電泳試劑的反應(yīng)性。</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="手性亞磷酰胺哌啶合成方法,哌啶" src="https://tyunfile.71360.com/WaterMark/UploadFile/shbdyykj/637439115837612467/2408769.png"></div><p style="text-indent:25px">β-酮砜已被確立為可用于制備多種含硫化合物的通用試劑。環(huán)狀β-酮砜是有前途的試劑之一，并且由于它們的可用性以及在合成各種范圍的多環(huán)砜中的可能應(yīng)用而特別有用。環(huán)狀砜基序存在于大量生物活性分子中。根據(jù)重要硫吡喃環(huán)的取代方式，這類化合物已顯示出多種生物活性，范圍從抵御炎癥和抗病毒到ATP敏感的鉀通道（KATP）開放劑?？骨喙庋蹌〥orzolamide和Metikran甚至成為市售藥物。由于其在多組分反應(yīng)（MCR）中的高反應(yīng)活性以及在各種S，N-雜環(huán)的合成中的廣適用性，研究人員對(duì)二氫2H-硫代吡喃-3（4H）-1,1-二氧化物1的興趣不斷增長。 MCR被公認(rèn)為是功能強(qiáng)大且高效的工具，它可以簡單且高通量地生成面向硫的雜環(huán)化合物的多樣性導(dǎo)向庫。在這項(xiàng)工作之前，酮砜1已成功用于各種硫代吡喃并[3,2-b]吡啶-1,1-二氧化物和硫代吡喃并[3,2-d]嘧啶的MCR合成中。通過易于使用的二氫-2H-硫噠卟啉-3（4H） - 1,1-二氧化氧化物，由一鍋多組分反應(yīng)（MCR）制備三系列新的環(huán)狀砜。聚鹵代硝基丁二烯作為多功能砌塊，用于生物可靶向替代的N-雜環(huán)化合物。PFA哌啶化合物</p><p style="text-indent:25px">哌啶.中文同義詞六氫吡啶六氫吡啶哌啶氮己環(huán)一氮六環(huán)派盯一氮六圜Ⅲ型聚丙烯聚丙烯(無規(guī)共聚) 胡椒啶。手性亞磷酰胺哌啶合成方法</p><p style="text-indent:25px">通過理論計(jì)算，獲得了哌啶催化的乙酰**與苯甲醛的Knoevenagel縮合反應(yīng)的自由能譜。甲醇胺的形成步驟涉及甲醇溶劑的催化作用，其分解過程是通過消除氫氧離子而沒有經(jīng)典的過渡態(tài)而發(fā)生的，從而產(chǎn)生亞胺離子。氫氧根離子使乙酰**脫質(zhì)子，形成攻擊亞胺離子的烯醇化物，并導(dǎo)致加成中間體。 ***一步涉及消除哌啶催化劑。我們的分析表明亞胺離子的形成具有比較高的勢壘，哌啶的催化作用促進(jìn)了消除步驟，而不是苯甲醛親電試劑的活化。動(dòng)力學(xué)實(shí)驗(yàn)方法導(dǎo)致觀察到的20.0 kcal mol-1的自由能壘，與基于自由能曲線的21.8 kcal mol-1的理論值非常吻合。手性亞磷酰胺哌啶合成方法</p><p> 上海畢得醫(yī)藥科技有限公司成立于2007年，總部位于上海市楊浦區(qū)理工大學(xué)國家大學(xué)科技園，是一家以醫(yī)藥中間體相關(guān)產(chǎn)品的研發(fā)、生產(chǎn)、銷售及合成定制為主的****。自公司成立以來，始終堅(jiān)持信譽(yù)至上，質(zhì)量過硬的企業(yè)信條，產(chǎn)品被應(yīng)用于生命科學(xué)、有機(jī)化學(xué)、材料科學(xué)、分析化學(xué)與其他學(xué)科的研發(fā)及生產(chǎn)領(lǐng)域，銷售范圍遍及全球。目前，公司與諸多國內(nèi)**醫(yī)藥研發(fā)單位建立了合作伙伴關(guān)系。 </p> <p> 公司位于上海理工大學(xué)科技園的行政辦公中心面積達(dá)1,700平米，在藥谷設(shè)立的研發(fā)中心面積1,800平米，包括化學(xué)合成實(shí)驗(yàn)室和公斤級(jí)實(shí)驗(yàn)室，并配有現(xiàn)代化倉儲(chǔ)物流中心。公司優(yōu)勢產(chǎn)品包括特色雜環(huán)化合物、含氟化合物、手性化合物、氨基酸及其衍生物、硼酸及其衍生物等，已有多項(xiàng)科研項(xiàng)目獲得國家發(fā)明專利。 </p> <p> 為確保產(chǎn)品質(zhì)量，公司引進(jìn)了先進(jìn)齊全的分析測試設(shè)備，包括400MHz核磁共振儀(NMR)、電感耦合等離子體發(fā)射光譜儀(ICP)、液質(zhì)聯(lián)用儀(LCMS)等，并配以嚴(yán)格的質(zhì)量管理體系。公司簽有具備GMP資質(zhì)的合作工廠，配備專業(yè)的研發(fā)團(tuán)隊(duì)，形成了從小試、中試到工業(yè)化規(guī)模的生產(chǎn)能力，滿足客戶定制合成、目錄試劑采購及合成外包生產(chǎn)的需求。 </p></p><br /><p>文章來源地址: http://www.cdcfah.com/cp/2861484.html</p></div></div></div></div></div><div id="xshujsy" class="page-right twoColRt"><div id="cxqkdlv" class="box01 margin10 clearfix"><h3><a href="http://www.cdcfah.com/cp/">猜你喜歡</a></h3><div id="iezpapz" class="recomPic likePro"><a href="http://www.cdcfah.com/cp/814588.html"><div><img src="http://tyunfile.71360.com/UpLoadFile/2019/11/1/14/637082168864691056_lgpj_5374157.jpg" alt="福建ZF配件哪家強(qiáng) 信息推薦自業(yè)物資供應(yīng)" class="vcenter" onerror="javascript:this.src='/static/new_net_01/images/nopic.jpg';"></div><p>福建ZF配件哪家強(qiáng) 信息推薦自業(yè)物資供應(yīng)</p></a></div><div id="qhiii6p" class="recomPic likePro"><a href="http://www.cdcfah.com/cp/846569.html"><div><img 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