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class="proBig"><div id="yhtvc23" class="bigimg"><div><p class="pic"><img src="http://tyunfile.71360.com/UploadFile/shchaorui/637122256614697265/8139706.png" class="vcenter" onerror="javascript:this.src='/static/new_net_01/images/nopic.jpg';"></p></div></div><div id="fdfxu3z" class="smallimg"><div><p class="pic"><img src="http://tyunfile.71360.com/UploadFile/shchaorui/637122256614697265/8139706.png" class="vcenter" onerror="javascript:this.src='/static/new_net_01/images/nopic.jpg';"></p></div></div></div><div id="mvsp3ls" class="content"><p><span>需求數(shù)量：</span>0</p><p><span>價格要求：</span>面議</p><p><span>所在地：</span>上海市</p><p><span>包裝要求：</span><span style="color: #f30;"></span></p><p><span>產(chǎn)品關(guān)鍵詞：</span>北京EBV法細胞永生化技術(shù)服務,細胞永生化</p><p><span>***更新：</span>2020-08-26 08:06:11</p><p><span id="click" >瀏覽次數(shù)：0次</span></p><a rel="nofollow" class="button">聯(lián)系我們</a></div></div><div id="8by2seb" class="rightbox"><h3>公司基本資料信息</h3><p style="border:0;"><a rel="nofollow">上海朝瑞生物科技有限公司</a></p><p><span>聯(lián)系人：</span>仲先生</p><p><span>郵箱: </span>scienceladder@163.com</p><p><span>電話: </span>18621867065</p><p><span>傳真: </span>021_</p><p><span>網(wǎng)址: </span></p><p><span>手機: </span>021-54133071</p><p><span>地址: </span>上海市松江區(qū)廣富林路697號昂立大廈2113室</p><p>[當前離線] <a rel="nofollow"> [加為商友] </a><a rel="nofollow"> [發(fā)送信件] </a></p></div></div><div id="8oqnk7x" class="page-proshow02"><p class="title">詳細說明</p><div id="mg7gix2" class="box"><p><p> ***作者DirkHockemeyer說：“我們的研究結(jié)果對于如何考慮將**和端粒酶作為***靶點的**早的過程有所了解，也意味著端粒生物學在**發(fā)展的早期階段的作用已被極大地忽視。“我們在黑色素瘤中發(fā)現(xiàn)的其他**類型很可能是正確的，這也就意味著人們會更加仔細地觀察早期端?？s短作為**的*****機制的作用?！苯Y(jié)果將在8月17日在線報道為“科學”雜志的“***版”出版物上出現(xiàn)。從痣到**Hockemeyer及其加州大學伯克利分校的同事們與皮膚病理學家BorisBastian及其在UCSF的同事合作，發(fā)現(xiàn)永生化是一個兩步的過程，**初由端粒酶突變引起，但水平很低，北京EBV法細胞永生化技術(shù)服務。該突變位于端粒酶基因上游的一個啟動子（稱為TERT），調(diào)節(jié)端粒酶產(chǎn)生多少，北京EBV法細胞永生化技術(shù)服務。四年前，研究人員報告說，北京EBV法細胞永生化技術(shù)服務，大約70％的惡性黑素瘤在TERT啟動子中具有相同的突變。霍奇邁爾表示，TERT啟動子突變不能產(chǎn)生足夠的端粒末端使前*細胞永生化，但會延緩正常的細胞衰老，允許更多的時間進行更多的端粒酶轉(zhuǎn)化。他懷疑端粒酶水平足以延長**短的端粒，但不能使它們長久健康。如果細胞未能轉(zhuǎn)化端粒酶，它們也不能永生化，并且**終由短端粒死亡，因為染色體粘在一起，然后在細胞分裂時破碎。具有TERT啟動子突變的細胞更可能上調(diào)端粒酶。北京EBV法細胞永生化技術(shù)服務</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="北京EBV法細胞永生化技術(shù)服務,細胞永生化" src="http://tyunfile.71360.com/UploadFile/shchaorui/637122256614697265/8139706.png"></div><p> *基因法 </p> <p> 一些原*基因，如Myc, c-Jun, c-Ias, vsrc和Mdm2，通過基因轉(zhuǎn)染可介導目的細胞永生化。c-Myc是**早被發(fā)現(xiàn)的原*基因，有許多與瘤化相關(guān)的功能區(qū)域，其轉(zhuǎn)錄表達的蛋白通過核膜進入細胞核與端粒酶的啟動子結(jié)合位點特異性結(jié)合，誘導端粒酶mRNA快速表達，直接ji活端粒酶活性，促進細胞進入永生化。 </p> <p> 細胞永生化過程中，抑*基因如p53, pRb, BRCA1, DPC4等，通過等位基因隱性作用、抑*基因的顯性負作用等逐漸失去活性，細胞老化途徑受阻。實驗證明端粒酶的活性與抑*基因表達產(chǎn)物的下調(diào)有相關(guān)關(guān)系，推測抑*基因的失活協(xié)同端粒酶的ji活共同參與細胞永生化進程。 </p> <p> <br /> 北京EBV法細胞永生化技術(shù)服務</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="北京EBV法細胞永生化技術(shù)服務,細胞永生化" src="http://tyunfile.71360.com/UploadFile/shchaorui/637122256581992187/1600974.png"></div><p> 有助讓細胞永生化的突變對**產(chǎn)生是至關(guān)重要的，但是在一項新的研究中，來自美國加州大學伯克利分校等研究機構(gòu)的研究人員指出細胞變成永生化遠比原來想象的更為復雜。相關(guān)研究結(jié)果于2017年8月17日在線發(fā)表在Science期刊上，論文標題為“Mutations in the promoter of the telomerase gene TERT contribute to tumorigenesis by a two-step mechanism”。細胞永生化的關(guān)鍵是一種被稱作端粒酶的酶，它讓染色體在經(jīng)常分裂的細胞中保持健康。這種酶延長染色體末端的端粒，在每次細胞分裂期間，這些端粒就會變短。當端粒太短時，染色體末端彼此間連接在一起，當細胞分裂時，這會造成破壞，在大多數(shù)情況下會殺死細胞。鑒于端粒隨著細胞年齡的增加而變短，科學家們從理論上認為，從不會衰老的*細胞通過產(chǎn)生細胞在正常情形下不會產(chǎn)生的端粒酶而變得永生化，從而是得這些細胞長久性地保持較長的端粒。經(jīng)估計，90%的惡性**利用端粒酶實現(xiàn)永生化，而且提出的多種**療法都著重關(guān)注降低端粒酶在**中的產(chǎn)生。 </p><p> 眾所周知，原代細胞**真實地反映特定細胞在體內(nèi)的生理狀態(tài)。然而，它們一般傳不了幾代就會停止增殖并死亡。對于一些需要大量細胞進行的實驗比如生化分析，遺傳篩選等，無法使用原代細胞。這阻礙了原代細胞在實驗室的應用。另外，一些稀有疾病獲得的血液或者組織樣本比較少，導致獲得的細胞數(shù)目比較有限。限制了后續(xù)實驗的正常進行。而對于可以無限傳代的細胞系，雖然沒有衰老的問題，但它們通常包含許多遺傳突變，表現(xiàn)出不穩(wěn)定的核型，蛋白質(zhì)表達模式也與細胞類型不相稱。問題來了，是否有一種辦法可以使原代細胞獲得永生化的同時維持正常細胞的生理特性呢？引起細胞永生化的因素很多，其中端粒酶在這一過程中發(fā)揮重要作用。端粒是真核細胞染色體末端的一種特殊結(jié)構(gòu)。由端粒DNA和端粒蛋白質(zhì)組成。正常動物細胞DNA的端粒隨著細胞分裂而縮短，當縮短到一定長度時細胞將停止增殖并死亡。將原代細胞轉(zhuǎn)染端粒酶逆轉(zhuǎn)錄酶cDNA（humantelomerasereversetranscriptase,hTERT），可以***端粒酶活性，維持端粒長度，阻止染色體端粒降解，誘導細胞永生化。有研究表明，hTERT介導的永生化細胞可保持正常細胞的生理特性。通過對多種hTERT永生化細胞系研究確認。</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="北京EBV法細胞永生化技術(shù)服務,細胞永生化" src="http://tyunfile.71360.com/UploadFile/shchaorui/637122256594023437/7214116.png"></div><p> 已傳25代,傳代時間為5-6天,傳代比為1:2-3。USEC-1細胞在無血清培養(yǎng)基中能正常生長。軟瓊脂糖培養(yǎng)、裸鼠致瘤試驗陰性。結(jié)論本實驗成功建立了大鼠橢圓囊上皮細胞永生化細胞系USEC-1,并進行了初步的鑒定。本細胞系基本上保留了原代USEC細胞的表形特征,又不具有瘤細胞特征,可用于毛細胞分裂、分化、再生及內(nèi)耳分子遺傳機制研究?！咀髡邌挝弧浚赫憬≈嗅t(yī)院【分類號】：R764下載全文更多同類文獻PDF全文下載CAJ全文下載(如何獲取全文？歡迎：購買知網(wǎng)充值卡、在線充值、在線咨詢)CAJViewer閱讀器支持CAJ、PDF文件格式，AdobeReader*支持PDF格式【相似文獻】中國期刊全文數(shù)據(jù)庫**條1鄭貴亮;郭維;翟所強;;脂質(zhì)體轉(zhuǎn)染前庭橢圓囊上皮細胞的影響因素[J];山東醫(yī)藥;2007年33期2楊仲昆;;人內(nèi)耳橢圓囊內(nèi)淋巴管瓣膜及其與橢圓囊管的關(guān)系[J];解剖學通報;1965年03期3楊占泉;;美尼爾氏病橢圓囊和內(nèi)淋巴管的基底膜病理[J];國外醫(yī)學.耳鼻咽喉科學分冊;1986年04期4;成纖維細胞生長因子受體在***鏈霉素損傷的成年鼠橢圓囊中的表達[J];國外醫(yī)學(耳鼻咽喉科學分冊);1999年06期5賈宏博,于立身,王奎年,戴建國,畢紅哲;橢圓囊和球囊在線加速度前庭知覺中的相互作用[J];中華航空醫(yī)學雜志;1996年04期6。北京EBV法細胞永生化技術(shù)服務</p><p style="text-indent:25px">北京EBV法細胞永生化技術(shù)服務</p><p> 這并不令人吃驚雖然大多數(shù)**似乎需要端粒酶變得永生化，但已知只有約10％至20％的**在端粒酶基因上游的啟動子中發(fā)生單核苷酸變化。然而，這包括大約70％的黑色素瘤和50％的肝和膀胱*。Hockemeyer說，用來支持這種TERT啟動子突變上調(diào)端粒酶表達的理論的證據(jù)一直是自相矛盾的：*細胞往往具有較短端粒的染色體，但具有更高水平的端粒酶，這種高水平應當會產(chǎn)生更長的端粒。根據(jù)這些新的發(fā)現(xiàn)，端粒在*前細胞（precancerouscell）中比較短，這是因為端粒酶剛好足以維持而不延長端粒。Hockemeyer說，“我們的論文調(diào)和了關(guān)于攜帶這種突變的**的相互矛盾的信息?！痹摪l(fā)現(xiàn)還解決了另外一個**近的違反直覺的發(fā)現(xiàn)：具有更短端粒的人更能抵抗黑色素瘤。他說，其中的原因在于如果一種TERT啟動子突變會促進*前病灶（痣）向黑色素瘤轉(zhuǎn)化，那么在具有更短端粒的人中，在細胞上調(diào)表達端粒酶和讓它們變得永生化之前，這些細胞將會死掉。該研究還涉及對由人多能性干細胞分化的細胞進行基因改造，使之攜帶TERT啟動子突變，隨后追蹤它們變得永生化的進展過程。這些結(jié)果與從加州大學舊金山分校海倫迪勒家族綜合**中心的患者體內(nèi)獲得的人皮膚病灶樣品中觀察到的進展過程是相同的。北京EBV法細胞永生化技術(shù)服務</p><p style="text-indent:25px">上海朝瑞生物科技有限公司創(chuàng)立于2003-01-22，是一家服務型公司。公司業(yè)務涵蓋科研技術(shù)服務，應用技術(shù)服務，科研成果轉(zhuǎn)化，科學產(chǎn)品銷售等，價格合理，品質(zhì)有保證。公司秉持誠信為本的經(jīng)營理念，在化工深耕多年，以技術(shù)為先導，以自主產(chǎn)品為重點，發(fā)揮人才優(yōu)勢，打造化工質(zhì)量品牌。公司立足于全國市場，依托強大的研發(fā)實力，融合世界前沿的技術(shù)理念，飛快響應客戶的變化需求。</p></p><br /><p>文章來源地址: 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