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class="button">聯(lián)系我們</a></div></div><div id="iojez66" class="rightbox"><h3>公司基本資料信息</h3><p style="border:0;"><a rel="nofollow">上海朝瑞生物科技有限公司</a></p><p><span>聯(lián)系人：</span>仲先生</p><p><span>郵箱: </span>scienceladder@163.com</p><p><span>電話: </span>18621867065</p><p><span>傳真: </span>021_</p><p><span>網(wǎng)址: </span></p><p><span>手機: </span>021-54133071</p><p><span>地址: </span>上海市松江區(qū)廣富林路697號昂立大廈2113室</p><p>[當(dāng)前離線] <a rel="nofollow"> [加為商友] </a><a rel="nofollow"> [發(fā)送信件] </a></p></div></div><div id="mk4sup4" class="page-proshow02"><p class="title">詳細說明</p><div id="4bwzf42" class="box"><p><p style="text-indent:25px">給實驗動物終生或長期染毒某測試物質(zhì)后觀察動物**形成的試驗。標(biāo)準(zhǔn)的動物致*試驗是使用兩種性別和兩種動物,每個劑量組50只動物的終生試驗。通常選用大鼠和小鼠,3個以上的劑量組,以及所需的組織病理學(xué)檢查的詳細資料?；瘜W(xué)物致*性的陽性證據(jù)應(yīng)包括各個***、部位的**數(shù)、誘發(fā)罕見的**、出現(xiàn)**的潛伏期及所見**總數(shù)的增加。動物致*試驗作為預(yù)測人類致*危險的依據(jù)仍存在一系列問題。例如,人的接觸劑量一般遠低于動物實驗的劑量;人與動物對化學(xué)物的代謝可能不同,致*機制也不同，上海免疫原性毒理學(xué)安全性評價分析服務(wù),由國際**研究中心分類確定的人類致*物和可能人類致*物的數(shù)量遠低于動物致*試驗確定的動物致*物數(shù)量，上海免疫原性毒理學(xué)安全性評價分析服務(wù)，上海免疫原性毒理學(xué)安全性評價分析服務(wù)。藥理學(xué)的學(xué)科任務(wù)是要為闡明***作用及作用機制、改善***質(zhì)量、提高***療效、防治不良反應(yīng)提供理論依據(jù).上海免疫原性毒理學(xué)安全性評價分析服務(wù)</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="上海免疫原性毒理學(xué)安全性評價分析服務(wù),毒理學(xué)安全性評價" src="http://tyunfile.71360.com/UploadFile/shchaorui/637129699851884766/1874696.png"></div><p> 擴展資料：一、食品安全性毒理學(xué)評價實驗項目；***階段：急性毒性試驗，試驗項目：1.用霍恩氏法、機率單位法或寇氏法，測定經(jīng)口半數(shù)致死量（LD50）。如劑量達10克/公斤體重仍不引起動物死亡，則不必測定半數(shù)致死量。2.必要時進行七天喂養(yǎng)試驗。以上兩個項目均分別用兩種性別的小鼠或大鼠。第二階段：蓄積毒性和致突變試驗，試驗項目：1.蓄積系數(shù)法。用兩種性別的大鼠或小鼠，各20只。2.二十天試驗法。用兩種性別的大鼠或小鼠，每個劑量組雌雄各10只。以上兩種方法任選一種。第三階段：亞慢性毒性（包括繁殖、致畸）試驗和代謝試驗，試驗項目：。2.喂養(yǎng)繁殖試驗。3.喂養(yǎng)致畸試驗。4.傳統(tǒng)致畸試驗。第四階段：慢性毒性（包括致*）試驗，試驗項目：可將兩年慢性毒性試驗和致*試驗結(jié)合在一個動物試驗中進行。用兩種性別的大鼠或小鼠。二：食品安全性毒理學(xué)評價實驗要求：1、凡屬我國創(chuàng)制的新化學(xué)物質(zhì)，一般要求進行四個階段的試驗。特別是對其中化學(xué)結(jié)構(gòu)提示有慢性毒性或致*作用可能者，產(chǎn)量大、使用面積廣、攝入機會多者，必需進行全部四個階段的試驗。2、凡屬與已知物質(zhì)（指經(jīng)過安全性評價并允許使用者）的化學(xué)結(jié)構(gòu)基本相同的衍生物，則可根據(jù)***、二、三階段試驗的結(jié)果。北京給藥毒理學(xué)安全性評價藥效學(xué)研究方法很多，概括講可分綜合和分析法。</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="上海免疫原性毒理學(xué)安全性評價分析服務(wù),毒理學(xué)安全性評價" src="http://tyunfile.71360.com/UploadFile/shchaorui/637129699852187500/2173424.png"></div><p> ***代謝分析服務(wù)介紹（1）***體外代謝研究 </p> <p> 肝微粒體代謝穩(wěn)定性研究（小鼠、大鼠、狗、猴或人） </p> <p> 肝細胞代謝穩(wěn)定性（小鼠、大鼠、狗、猴或人） </p> <p> 代謝產(chǎn)物結(jié)構(gòu)分析鑒定（微粒體、肝細胞） </p> <p> 代謝產(chǎn)物定量分析（微粒體、肝細胞） </p> <p> 活性代謝物研究 </p> <p> ***代謝相互作用（DDI） </p> <p> ***主要代謝酶的鑒定 </p> <p> CYP450s表型研究 </p> <p> 血漿/蛋白結(jié)合測定（2）體內(nèi)***代謝與藥代動力學(xué)研究 </p> <p> 體內(nèi)藥代動力學(xué)實驗（小鼠、大鼠、狗、猴） </p> <p> 不同給藥途徑（靜脈注射、口服、皮下及肌肉注射）的單次、多次給藥藥代動力學(xué)研究 </p> <p> 生物利用度研究（F%） </p> <p> ***在體內(nèi)各組織的分布研究 </p> <p> ***的排泄研究 </p> <p> ***制劑的生物利用度和生物等效性研究 </p><p style="text-indent:25px">毒性亦稱生物有害性，一般是指外源性化學(xué)物質(zhì)與生命機體接觸或進入生命活性體體內(nèi)后，能引起直接或間接損害作用的相對能力。毒性除與物質(zhì)本身的理化性質(zhì)有關(guān)外，與劑量、接觸途徑、接觸時間有密切關(guān)系，在一定意義上，只要超過閾值，任何物質(zhì)對機體都具有毒性，如果低于一定量，任何物質(zhì)都不具有毒性，在大多數(shù)情況下與機體接觸的量是決定物質(zhì)是否有毒的重要因素。微譜醫(yī)藥在對具體化合物進行危險度評估時，首先通過查找美國國家醫(yī)藥圖書館的Toxline或歐盟OECD的SIDS等數(shù)據(jù)庫來確定目標(biāo)化合物的毒性數(shù)據(jù)，如：NOEL、LOEL、LD50等。對于沒有毒性研究數(shù)據(jù)的化合物，可以選擇適宜的毒性試驗，根據(jù)毒性試驗結(jié)果計算NOEL和PDE，再按照相應(yīng)制劑的每日比較大服用量計算限度?？傊?，我們結(jié)合ICH的要求，1）通過符合ICHM7指導(dǎo)原則的軟件進行基因毒性預(yù)測；2）檢索已有基因毒性雜質(zhì)數(shù)據(jù)庫；3）根據(jù)相關(guān)數(shù)據(jù)制定合理的限度。藥理是醫(yī)學(xué)院校必修的一門課，指導(dǎo)臨床用藥。</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="上海免疫原性毒理學(xué)安全性評價分析服務(wù),毒理學(xué)安全性評價" src="http://tyunfile.71360.com/UploadFile/shchaorui/637129699842666016/4400715.png"></div><p> 過體外試驗、動物試驗和人群觀察，發(fā)現(xiàn)和闡明被評價物質(zhì)（食品或與食品有關(guān)的產(chǎn)品）的毒性和潛在的危害，以便對人類使用這種食品的安全性作出評價，并為制定預(yù)防措施和衛(wèi)生標(biāo)準(zhǔn)提供理論依據(jù)。毒理學(xué)實驗四個階段： </p> <p> <p> 第二階段：遺傳毒性試驗，30 天喂養(yǎng)試驗，傳統(tǒng)致畸試驗 </p> <p> 遺傳毒性試驗的組合應(yīng)該考慮原核細胞與真核細胞、體內(nèi)試驗與體外試驗相結(jié)合的原則。從Ames 試驗或V79/HGPRT 基因突變試驗、骨髓細胞微核試驗或哺乳動物骨髓細胞染色體畸變試驗、TK 基因突變試驗或小鼠精子畸形分析（或睪丸染色體畸變分析試驗）中分別各選一項。 </p> 對于具有選擇***理效應(yīng)的***，在進行臨床試驗前還需要測定該***在動物體內(nèi)的吸收、分布及消除消除過程。上海免疫原性毒理學(xué)安全性評價分析服務(wù)</p><p style="text-indent:25px">對照品系指非臨床研究中與供試品作比較的物質(zhì)。上海免疫原性毒理學(xué)安全性評價分析服務(wù)</p><p> 按照我國衛(wèi)生部《食品安全毒理學(xué)評價程序和檢驗方法規(guī)范》，采用急性毒性試驗、Ames試驗、小鼠骨髓嗜多染紅細胞微核試驗和小鼠精子畸形試驗對植物甾醇作為食品添加劑和保健食品原料的食用安全性進行評價。結(jié)果顯示：大、小鼠急性經(jīng)口LD50大于5 000 mg/kg，Ames試驗、小鼠骨髓嗜多染紅細胞微核試驗和小鼠精子畸形試驗結(jié)果均為陰性。由此得出植物甾醇屬于實際***物，可以作為一種食品添加劑和保健食品原料進行開發(fā)、利用。 </p> <p> 關(guān)鍵詞：植物甾醇；安全性；毒理試驗；Ames試驗；微核試驗；精子畸形試驗上海免疫原性毒理學(xué)安全性評價分析服務(wù)</p><p style="text-indent:25px">上海朝瑞生物科技有限公司是一家1.發(fā)布科研技術(shù) 2.發(fā)布應(yīng)用技術(shù) 3.發(fā)布專業(yè)專長 4.發(fā)布科研成果 5.發(fā)布我的需求 6.發(fā)布篩選檢驗檢測服務(wù) 7.發(fā)布協(xié)同代研發(fā)服務(wù) 8.發(fā)布升級改造產(chǎn)品服務(wù) 9.發(fā)布實驗室及儀器設(shè)備共享 10.發(fā)布培訓(xùn)基地共享 11.發(fā)布工廠代加工及共享車間 12.發(fā)布科研/項目團隊招聘13.發(fā)布研究生婚戀 14.發(fā)布項目整包服務(wù) 15.發(fā)布資源交換業(yè)務(wù)的公司，致力于成為客戶業(yè)務(wù)創(chuàng)新、化工可信賴的合作伙伴。上海朝瑞科技擁有一支經(jīng)驗豐富、技術(shù)創(chuàng)新的專業(yè)研發(fā)團隊，以高度的專注和執(zhí)著為客戶提供科研技術(shù)服務(wù)，應(yīng)用技術(shù)服務(wù)，科研成果轉(zhuǎn)化，科學(xué)產(chǎn)品銷售。上海朝瑞科技致力于把技術(shù)上的創(chuàng)新展現(xiàn)成對用戶產(chǎn)品上的貼心，為用戶帶來***體驗。上海朝瑞科技始終關(guān)注化工行業(yè)。海納百川，有容乃大，國內(nèi)外同行的智慧都是促使我們前行的力量。</p></p><br /><p>文章來源地址: http://www.cdcfah.com/cp/1108563.html</p></div></div></div></div></div><div id="o4rmore" class="page-right twoColRt"><div id="61qpvje" class="box01 margin10 clearfix"><h3><a href="http://www.cdcfah.com/cp/">猜你喜歡</a></h3><div id="gxkfioj" class="recomPic likePro"><a href="http://www.cdcfah.com/cp/814588.html"><div><img src="http://tyunfile.71360.com/UpLoadFile/2019/11/1/14/637082168864691056_lgpj_5374157.jpg" 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