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class="content"><p><span>需求數(shù)量：</span>0</p><p><span>價格要求：</span>面議</p><p><span>所在地：</span>上海市</p><p><span>包裝要求：</span><span style="color: #f30;"></span></p><p><span>產(chǎn)品關(guān)鍵詞：</span>天津Claudin18.2蛋白推薦廠家,Claudin18.2蛋白</p><p><span>***更新：</span>2020-08-31 09:07:34</p><p><span id="click" >瀏覽次數(shù)：0次</span></p><a rel="nofollow" class="button">聯(lián)系我們</a></div></div><div id="sgqxh9y" class="rightbox"><h3>公司基本資料信息</h3><p style="border:0;"><a rel="nofollow">上海朝瑞生物科技有限公司</a></p><p><span>聯(lián)系人：</span>仲先生</p><p><span>郵箱: </span>scienceladder@163.com</p><p><span>電話: </span>18621867065</p><p><span>傳真: </span>021_</p><p><span>網(wǎng)址: </span></p><p><span>手機(jī): </span>021-54133071</p><p><span>地址: </span>上海市松江區(qū)廣富林路697號昂立大廈2113室</p><p>[當(dāng)前離線] <a rel="nofollow"> [加為商友] </a><a rel="nofollow"> [發(fā)送信件] </a></p></div></div><div id="gl7ikpj" class="page-proshow02"><p class="title">詳細(xì)說明</p><div id="u7ew3tt" class="box"><p>CLDN18，天津Claudin18.2蛋白推薦廠家.2作為一個高度特異性的細(xì)胞表面分子，在正常的組織中*表達(dá)在分化的胃粘膜上表皮細(xì)胞上，不表達(dá)在胃干細(xì)胞上。在原發(fā)性胃*及其轉(zhuǎn)移后**類型中大部分都表達(dá)CLDN18.2分子，另外在胰腺*，食管*，卵巢*，肺*中也常常觀察到CLDN18.2被表達(dá)。CLDN18.2作為細(xì)胞膜表面蛋白，暴露的胞外結(jié)構(gòu)允許抗體的結(jié)合，這些特點表明CLDN18.2是一個理想的性單克隆抗體開發(fā)的靶點。 <p> Claudiximab (IMAB362) </p> <p> Claudiximab是一個嵌合抗體，來源于小鼠，可變區(qū)與人的IgG1恒定區(qū)融合表達(dá)，其通過CHO表達(dá)體系生產(chǎn)，天津Claudin18.2蛋白推薦廠家，通過結(jié)合到**細(xì)胞表面引起ADCC和CDC作用，天津Claudin18.2蛋白推薦廠家，也可以誘導(dǎo)細(xì)胞凋亡和細(xì)胞增殖。與化療聯(lián)用，可以增強(qiáng)T細(xì)胞浸潤和誘導(dǎo)促炎因子。天津Claudin18.2蛋白推薦廠家</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="天津Claudin18.2蛋白推薦廠家,Claudin18.2蛋白" src="http://tyunfile.71360.com/UploadFile/shchaorui/637123969977363281/5123419.png"></div><p> 靶點介紹CLDN18屬于Claudins蛋白家族成員，Claudin蛋白由ShoichiroTsukita及其同事在1998年發(fā)現(xiàn)。在人體內(nèi)由CLDN18基因編碼，該蛋白表達(dá)在上皮上。上皮細(xì)胞是位于皮膚或腔道表層的細(xì)胞，主要功能是作為物理和化學(xué)屏障，上皮細(xì)胞間連接**主要的連接是緊密連接。Claudin是構(gòu)成細(xì)胞緊密連接的重要分子，緊密連接決定了上皮細(xì)胞的滲透性，也起到阻擋細(xì)胞膜表面蛋白和脂質(zhì)擴(kuò)散的作用1。圖1小腸上皮細(xì)胞的三種連接方式：緊密連接、橋粒和間隙連接2通過形態(tài)學(xué)研究，預(yù)測Claudin蛋白存在于所有的脊椎動物中和背囊動物中。對于大部分物種*有幾種Claudin蛋白，哺乳動物中有27中Claudin基因，并不是這些基因存在于一種物種中，例如，人有26個Claudin基因，唯獨缺少CLDN-13基因。CLDN18基因及蛋白結(jié)構(gòu)特征：人的CLDN18基因具有兩個不同的1號外顯子，轉(zhuǎn)錄后經(jīng)過可變剪接**終生成*在N端具有不同序列的兩個蛋白亞型，如圖2所示。，均具有四個跨膜結(jié)構(gòu)域，NH2端和COOH端位于胞內(nèi)，具有兩個胞外環(huán)（ExtracellularLoops：ECL1，ECL2）。，如圖2所示。鑒于CLDN18的膜蛋白特性，，篩選針對。圖2；；，方框分別表示(E)和(E)特異的***外顯子4；，藍(lán)色框表示***個胞外環(huán)。天津Claudin18.2蛋白推薦廠家</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="天津Claudin18.2蛋白推薦廠家,Claudin18.2蛋白" src="http://tyunfile.71360.com/UploadFile/shchaorui/637123969953671875/8173621.png"></div><p> 29日日本制藥企業(yè)安斯泰來宣布將以4.6億美元首付、9.6億潛在里程金收購德國生物技術(shù)公司Ganymed。Ganymed的**資產(chǎn)Claudin18.2抗體IMAB362曾是今年ASCO的比較大。在胃*二期試驗中比標(biāo)準(zhǔn)化療延長生存期（13.2 對8.4 個月），在Claudin18.2高表達(dá)患者IMAB362優(yōu)勢更明顯（16.7 對9 個月）。 </p> <p> 安斯泰來2009年曾以6.5億的白菜價從Medivation收購了前列腺* Xtandi的美國以外權(quán)益，今年Medivation以140億美元天價被輝瑞收購，主要是因為Xtandi的潛在價值。 14億收購一個二期臨床資產(chǎn)雖然看著不便宜，但I(xiàn)MAB362的療效非常好，而且有可靠的生物標(biāo)記，所以開發(fā)風(fēng)險較小。和**近其它**資產(chǎn)比這個價格還算偏低的。 </p><p> 緊密連接被破壞，claudin蛋白質(zhì)失去了其主要作用。IMAB362是較早靶向claudin。當(dāng)該抗體附著在**細(xì)胞的，被涂在抗體上的各種類型的細(xì)胞和可溶性免疫效應(yīng)物通過殺死**細(xì)胞產(chǎn)生應(yīng)答。這些過程抗體-依賴性細(xì)胞-介導(dǎo)的細(xì)胞毒性（ADCC）和補(bǔ)體-依賴性細(xì)胞毒性（CDC）。關(guān)于這項研究胃*是世界上第五種**常見的**，2012年有接近100萬新增胃*病例。晚期或復(fù)發(fā)性胃*的標(biāo)準(zhǔn)*****是化療。曲妥珠單抗加入化療為HER2-陽性**患者提供一定的生存獲益，但是所有胃*中只有15%為HER2-陽性。這項研究納入161例晚期或復(fù)發(fā)性胃*或胃食管交界*，并且他們**中claudin（來自**活檢樣本的分析評估聯(lián)合經(jīng)驗證的CE-標(biāo)志的診斷分析）。這些患者之前沒有接受過轉(zhuǎn)移性*的***，接受HER2曲妥珠單抗***的患者不符合入組要求?；颊弑浑S機(jī)分配接受標(biāo)準(zhǔn)化療（表柔比星，奧沙利鉑，和卡培他濱）或者化療聯(lián)合IMAB362。關(guān)鍵發(fā)現(xiàn)與單純化療相比較，IMAB362將平均疾病進(jìn)展時間從，中位總生存期從。在比較高claudin，化療+IMAB362的中位總生存期是，單純化療的中位總生存期是9個月。根據(jù)作者介紹，這種***耐受性良好。嘔吐（對照組：vsIMAB362組：）和低血細(xì)胞計數(shù)或者中性粒細(xì)胞減少。</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="天津Claudin18.2蛋白推薦廠家,Claudin18.2蛋白" src="http://tyunfile.71360.com/UploadFile/shchaorui/637123969973447266/5364157.png"></div><p style="text-indent:25px">Claudin是由日本科學(xué)家Shoichiro Tsukita所發(fā)現(xiàn)，當(dāng)初發(fā)現(xiàn)Claudin和**沒有什么關(guān)系。Tsukita對細(xì)胞的基本運作感興趣，于1993年發(fā)現(xiàn)一類叫occludin的細(xì)胞粘合蛋白，以為解決了細(xì)胞粘合問題。后來發(fā)現(xiàn)細(xì)胞敲除occludin仍會粘合，他們沒有放棄找到了隱藏更深的Claudin。不幸的是年*52歲的Tsukita于2005年死于胰腺*，死前4天此公還在實驗室工作，他找到Claudin據(jù)說也是用了日本科學(xué)家常用的brutal force戰(zhàn)術(shù)。制藥工業(yè)的真金白銀無疑是新藥不可或缺的一個因素，但沒有Tsukita這樣偉大科學(xué)家的貢獻(xiàn)新藥也無從談起?，F(xiàn)在IMAB362除了胃*也獲得奪去Tsukita生命的胰腺*孤兒藥地位。天津Claudin18.2蛋白推薦廠家</p><p style="text-indent:25px">天津Claudin18.2蛋白推薦廠家</p><p> 這對于中國**醫(yī)生具有開創(chuàng)性的作用，非常希望這項研究的結(jié)果不*可以給研究者帶來更多信心，也能為TNBC患者帶來更多希望。作為一種獨特的乳腺*亞型，TNBC的***效果還不能滿足患者的生存需求。目前的臨床實踐重點在優(yōu)化化療方案上，此外，未來免疫***與化療的聯(lián)合也是一個重要的探索方向。有不少關(guān)于TNBC有效靶點和免疫***方面的探索，Impassion130是目前***的免疫***在mTNBC中取得陽性結(jié)果的Ⅲ期研究，atezolizumab+白蛋白紫杉醇也已在歐美獲批PD-L1+TNBC的晚期*****適應(yīng)癥，為TNBC患者帶來了新希望。相信隨著各項研究的進(jìn)展及***方案的應(yīng)用，TNBC患者的預(yù)后將會逐步得以改善。(本網(wǎng)站所有內(nèi)容，凡注明來源為“醫(yī)脈通”，版權(quán)均歸醫(yī)脈通所有，未經(jīng)授權(quán)，任何媒體、網(wǎng)站或個人不得轉(zhuǎn)載，否則將追究法律責(zé)任，授權(quán)轉(zhuǎn)載時須注明“來源：醫(yī)脈通”。本網(wǎng)注明來源為其他媒體的內(nèi)容為轉(zhuǎn)載，轉(zhuǎn)載*作觀點分享，版權(quán)歸原作者所有，如有侵犯版權(quán)，請及時聯(lián)系我們。天津Claudin18.2蛋白推薦廠家</p><p style="text-indent:25px">上海朝瑞生物科技有限公司是一家1.發(fā)布科研技術(shù) 2.發(fā)布應(yīng)用技術(shù) 3.發(fā)布專業(yè)專長 4.發(fā)布科研成果 5.發(fā)布我的需求 6.發(fā)布篩選檢驗檢測服務(wù) 7.發(fā)布協(xié)同代研發(fā)服務(wù) 8.發(fā)布升級改造產(chǎn)品服務(wù) 9.發(fā)布實驗室及儀器設(shè)備共享 10.發(fā)布培訓(xùn)基地共享 11.發(fā)布工廠代加工及共享車間 12.發(fā)布科研/項目團(tuán)隊招聘13.發(fā)布研究生婚戀 14.發(fā)布項目整包服務(wù) 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