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歡迎來電上海朝瑞生物科技供應(yīng)</h1><div id="syi6gu0" class="proBig"><div id="is6s8su" class="bigimg"><div><p class="pic"><img src="http://tyunfile.71360.com/UploadFile/shchaorui/637129699834218750/8309701.png" class="vcenter" onerror="javascript:this.src='/static/new_net_01/images/nopic.jpg';"></p></div></div><div id="okqqyuw" class="smallimg"><div><p class="pic"><img src="http://tyunfile.71360.com/UploadFile/shchaorui/637129699834218750/8309701.png" class="vcenter" onerror="javascript:this.src='/static/new_net_01/images/nopic.jpg';"></p></div></div></div><div id="cuui8s0" class="content"><p><span>需求數(shù)量：</span>0</p><p><span>價格要求：</span>面議</p><p><span>所在地：</span>上海市</p><p><span>包裝要求：</span><span style="color: #f30;"></span></p><p><span>產(chǎn)品關(guān)鍵詞：</span>上海局部毒理學(xué)安全性評價檢測服務(wù),毒理學(xué)安全性評價</p><p><span>***更新：</span>2020-09-06 08:57:33</p><p><span id="click" >瀏覽次數(shù)：0次</span></p><a rel="nofollow" class="button">聯(lián)系我們</a></div></div><div id="2kk4cia" class="rightbox"><h3>公司基本資料信息</h3><p style="border:0;"><a rel="nofollow">上海朝瑞生物科技有限公司</a></p><p><span>聯(lián)系人：</span>仲先生</p><p><span>郵箱: </span>scienceladder@163.com</p><p><span>電話: </span>18621867065</p><p><span>傳真: </span>021_</p><p><span>網(wǎng)址: </span></p><p><span>手機(jī): </span>021-54133071</p><p><span>地址: </span>上海市松江區(qū)廣富林路697號昂立大廈2113室</p><p>[當(dāng)前離線] <a rel="nofollow"> [加為商友] </a><a rel="nofollow"> [發(fā)送信件] </a></p></div></div><div id="ymi4mem" class="page-proshow02"><p class="title">詳細(xì)說明</p><div id="kkgk6s2" class="box"><p><p style="text-indent:25px">2017年中國毒理學(xué)***毒理與安全性評價學(xué)術(shù)大會于2017年05月06-08日在長沙成功召開。此次大會由中國毒理學(xué)會***毒理與安全性評價專業(yè)委員會主辦，湖南省***安全評價研究中心、湖南省新藥藥效與安全評價重點實驗室、***醫(yī)學(xué)科學(xué)院毒物***研究所、國家北京***安全評價研究中心共同承辦，上海局部毒理學(xué)安全性評價檢測服務(wù)。大會主題是“窮新藥研發(fā)洪荒之力，上海局部毒理學(xué)安全性評價檢測服務(wù)，仗安全評價保駕護(hù)航”，上海局部毒理學(xué)安全性評價檢測服務(wù)，在國際上OECD、美國FDA 和我國GLP法規(guī)和相關(guān)安全性評價研究技術(shù)指導(dǎo)原則進(jìn)行修訂的背景下，我國新藥研制重大專項十三五發(fā)展規(guī)劃和十三五國家藥品安全規(guī)劃***實施的前提下和我國新藥審評和監(jiān)管*****起得***進(jìn)展的大好形勢下，旨在為我國***毒理學(xué)工作者就國內(nèi)外GLP規(guī)范修訂與實施***動向、***毒理學(xué)研究的***進(jìn)展和***臨床前安全性評價新思路、新技術(shù)創(chuàng)建一個**學(xué)術(shù)交流平臺。對于具有選擇***理效應(yīng)的***，在進(jìn)行臨床試驗前還需要測定該***在動物體內(nèi)的吸收、分布及消除消除過程。上海局部毒理學(xué)安全性評價檢測服務(wù)</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="上海局部毒理學(xué)安全性評價檢測服務(wù),毒理學(xué)安全性評價" src="http://tyunfile.71360.com/UploadFile/shchaorui/637129699834218750/8309701.png"></div><p style="text-indent:25px">***安全性評價方面有專業(yè)的團(tuán)隊和實戰(zhàn)經(jīng)驗，可提供高質(zhì)量的數(shù)據(jù)和快速的周轉(zhuǎn)期以支持各項***安全評價研究。毒理學(xué)研究可按照非GLP或者GLP標(biāo)準(zhǔn)執(zhí)行。單次給藥毒性試驗（嚙齒類和非嚙齒類）反復(fù)給藥毒性試驗（嚙齒類和非嚙齒類）安全藥理試驗：***系統(tǒng)研究、心血管系統(tǒng)（犬和猴的遙測和非遙測技術(shù)）、呼吸系統(tǒng)、hERG遺傳毒性試驗生殖毒性試驗[生育力與早期胚胎發(fā)育毒性試驗(生殖I段)、胚胎-胎仔發(fā)育毒性試驗（生殖II段）]免疫原性試驗毒代動力學(xué)局部毒性試驗（溶血、過敏、刺激性試驗）新給藥技術(shù)的毒理試驗：吸入毒理上海局部毒理學(xué)安全性評價檢測服務(wù)單一地考察***對某一部分的作用。深入研究還包括細(xì)胞水平、分子水平的分析研究。</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="上海局部毒理學(xué)安全性評價檢測服務(wù),毒理學(xué)安全性評價" src="http://tyunfile.71360.com/UploadFile/shchaorui/637129699841435547/3737546.png"></div><p style="text-indent:25px">細(xì)胞水平的***篩選是更接近生理條件的一種***篩選模型，其模型是擬設(shè)計***作用的靶細(xì)胞，應(yīng)用細(xì)胞培養(yǎng)技術(shù)獲取所需細(xì)胞，將這些細(xì)胞與候選化合物相互作用，通過與生化水平篩選類似的檢測技術(shù)測定化合物的作用能力，從而對化合物進(jìn)行篩選。生化水平的***篩選操作相對簡單，成本較低，但是由于***在體內(nèi)的作用并不**取決于其與靶酶的作用程度，吸收、分布、代謝、排泄均會對***的作用產(chǎn)生極大的影響，**一道薄薄的細(xì)胞膜就能夠阻擋住許多候選化合物成為***的道路，因而生化水平的***篩選不確定因素更多，誤篩率更高。細(xì)胞水平的***篩選模型更接近生理條件，篩選的準(zhǔn)確率更高，但是需要建立細(xì)胞模型，操作更復(fù)雜，成本更高，數(shù)據(jù)之間的平行形較差，另外由于技術(shù)的限制，有些靶標(biāo)還不能進(jìn)行細(xì)胞水平的***篩選。</p><p style="text-indent:25px">劑量皮膚用藥的劑量-效應(yīng)關(guān)系的劑量改變?nèi)绻唵蔚貜慕o藥的濃度和重量或體積去確定是不妥當(dāng)?shù)?。一個定量的制劑涂于皮膚表面后的真實劑量取決于透入皮膚的藥量,而后者又取決于下列諸多因素,如:①不同種系、不同**、不同疾病下的皮膚角質(zhì)層狀態(tài);②***的物理、化學(xué)性質(zhì);③基質(zhì)的性狀、特性和成分;④制劑的濃度,接觸時間和面積、使用狀態(tài)等。如果上述條件均固定,那么***從制劑基質(zhì)中的釋放度在線性范圍內(nèi)的制劑的不同濃度才**一種相對劑量,后者的經(jīng)皮穿透形成的皮內(nèi)濃度才能與血藥濃度和組織濃度一樣可以作為劑量-效應(yīng)可靠指標(biāo)。體外實驗的有效濃度也只有與皮內(nèi)濃度對應(yīng)才能被認(rèn)為有意義。在遵循以上原則的基礎(chǔ)上進(jìn)行皮膚給藥的毒性試驗,仍然存在一下的問題:①簡單地以增加濃度來增加劑量,制劑不合乎藥劑學(xué)制備要求;②簡單地以使用的重量或體積表示劑量,忽視單位皮膚面積的承受量;③以千克體重給藥量表示劑量;④不能保證排除動物經(jīng)口自舔及互舔;⑤未估計長期毒性試驗使用正常動物、完整皮膚進(jìn)行試驗的可能偏差,如大分子***臨床可通過破損皮膚而基本不透過正常皮膚等。新藥的藥效學(xué)研究主要指對bai其藥理作用的觀測和作用機(jī)理的探討。</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="上海局部毒理學(xué)安全性評價檢測服務(wù),毒理學(xué)安全性評價" src="http://tyunfile.71360.com/UploadFile/shchaorui/637129699839287110/5826880.png"></div><p style="text-indent:25px">食品安全性毒理學(xué)評價是運用現(xiàn)代毒理學(xué)理論，并結(jié)合流行病學(xué)調(diào)查分析和闡明食品或食品中的特定物質(zhì)的毒性及其潛在危害，預(yù)測人體接觸后可能對人體健康產(chǎn)生影響的性質(zhì)和強度，提出食用安全風(fēng)險和預(yù)防措施的一門技術(shù)。 [1] 相關(guān)法律法規(guī)編輯（1）《食品安全性毒理學(xué)評價程序》；（2）《農(nóng)藥安全性毒理學(xué)評價程序》；（3）《新藥（西藥）毒理學(xué)研究指導(dǎo)原則》；（4）《化妝品安全性評價程序和方法》；（5）《食品功能毒理學(xué)評價程序和檢驗方法》；（6）《食品毒理學(xué)實驗室操作規(guī)范》。在***安全性評價中***動力學(xué)和毒物動力學(xué)。上海局部毒理學(xué)安全性評價檢測服務(wù)</p><p style="text-indent:25px">新藥可通過實踐經(jīng)驗或理論指導(dǎo)下合成、篩選而發(fā)現(xiàn)。上海局部毒理學(xué)安全性評價檢測服務(wù)</p><p> 經(jīng)口半數(shù)致死量），了解受試物的毒性強度、性質(zhì)和可能的靶***，為進(jìn)一步進(jìn)行毒性試驗的劑量和毒性觀察指標(biāo)的選擇提供依據(jù)，并根據(jù)LD50進(jìn)行毒性分級。試驗項目：①霍恩氏法、機(jī)率單位法或寇氏法測定經(jīng)口半數(shù)致死量（LD50）；②7天喂養(yǎng)試驗。以上兩個項目分別用兩種性別的小鼠和（或）大鼠進(jìn)行結(jié)果判定：①LD50或7天喂養(yǎng)試驗的**小有作用劑量小于人的可能攝入量的10倍者，則放棄不再繼續(xù)試驗；②大于10倍者，可進(jìn)入下一階段試驗。為慎重起見，凡LD50在10倍左右時，應(yīng)進(jìn)行重復(fù)試驗，或用另一種方法進(jìn)行驗證。[2]安全毒理學(xué)評價（2）第二階段遺傳毒性試驗考慮原核細(xì)胞與真核細(xì)胞、體內(nèi)試驗和體外試驗相結(jié)合的原則選擇試驗組合，對受試物的遺傳毒性以及是否具有潛在致*作用進(jìn)行篩選。食品毒理學(xué)中的傳統(tǒng)致畸試驗是限定于受孕動物的觀察，了解受試物是否具有致畸作用。在急性毒性試驗的基礎(chǔ)上，通過30天喂養(yǎng)試驗，進(jìn)一步了解其毒性作用，觀察對生長發(fā)育的影響，并可初步估計比較大未觀察到有害作用的劑量。1.蓄積毒性試驗①目的：了解受試物在體內(nèi)的蓄積情況。②試驗項目：包括蓄積系數(shù)法和20天試驗法。蓄積系數(shù)法是用兩種性別的大鼠或小鼠，各20只。上海局部毒理學(xué)安全性評價檢測服務(wù)</p><p style="text-indent:25px">上海朝瑞生物科技有限公司致力于化工，是一家服務(wù)型公司。公司業(yè)務(wù)分為科研技術(shù)服務(wù)，應(yīng)用技術(shù)服務(wù)，科研成果轉(zhuǎn)化，科學(xué)產(chǎn)品銷售等，目前不斷進(jìn)行創(chuàng)新和服務(wù)改進(jìn)，為客戶提供良好的產(chǎn)品和服務(wù)。公司注重以質(zhì)量為中心，以服務(wù)為理念，秉持誠信為本的理念，打造化工良好品牌。上海朝瑞科技秉承“客戶為尊、服務(wù)為榮、創(chuàng)意為先、技術(shù)為實”的經(jīng)營理念，全力打造公司的重點競爭力。</p></p><br /><p>文章來源地址: http://www.cdcfah.com/cp/1177492.html</p></div></div></div></div></div><div id="kcquywy" class="page-right twoColRt"><div id="0oguksy" class="box01 margin10 clearfix"><h3><a href="http://www.cdcfah.com/cp/">猜你喜歡</a></h3><div id="iea8ci4" class="recomPic likePro"><a href="http://www.cdcfah.com/cp/814588.html"><div><img src="http://tyunfile.71360.com/UpLoadFile/2019/11/1/14/637082168864691056_lgpj_5374157.jpg" alt="福建ZF配件哪家強信息推薦自業(yè)物資供應(yīng)" class="vcenter" onerror="javascript:this.src='/static/new_net_01/images/nopic.jpg';"></div><p>福建ZF配件哪家強信息推薦自業(yè)物資供應(yīng)</p></a></div><div id="q00wimg" class="recomPic likePro"><a 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