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class="box"><p><p> 新藥的藥效學(xué)研究主要指對(duì)bai其藥理作用的觀測(cè)和作用機(jī)理的探討。內(nèi)容du包括： </p> <p> （一）觀測(cè)zhi生理機(jī)能的改變。如新藥對(duì)***系統(tǒng)產(chǎn)生興奮還是***；對(duì)心肌收縮力或胃腸道運(yùn)動(dòng)是加強(qiáng)還是減弱；對(duì)血管或支氣管是擴(kuò)張還是收縮等。 </p> <p> （二）測(cè)定生化指標(biāo)的變化，如血糖、電解質(zhì)；生理活性物質(zhì)，如血管緊張素、前列腺素、環(huán)磷苷濃度的改變等，北京免疫原性毒理學(xué)安全性評(píng)價(jià)技術(shù)服務(wù)。 </p> <p> （三）觀測(cè)組織形態(tài)學(xué)變化，如血細(xì)胞大小、甲狀腺大小、腎上腺皮質(zhì)萎縮等。 </p> <p> 二、藥效學(xué)研究的目的 </p> <p> 主要達(dá)到二個(gè)目的：一是確定***的***作用，二是確定***的一般藥理作用，北京免疫原性毒理學(xué)安全性評(píng)價(jià)技術(shù)服務(wù)。為新藥臨床試驗(yàn)提供可靠依據(jù)，北京免疫原性毒理學(xué)安全性評(píng)價(jià)技術(shù)服務(wù)。 </p> <p> 三、基礎(chǔ)藥效學(xué)研究方法 </p> <p> 藥效學(xué)研究方法很多，概括講可分綜合和分析法。所謂綜合法是指在整體動(dòng)物身上進(jìn)行，是在若干其它因素綜合參與下考察***作用，根據(jù)實(shí)驗(yàn)動(dòng)物情況不同，可分為正常動(dòng)物法和實(shí)驗(yàn)***法。所謂分析方法是采用離體臟器，例如離體腸管、離體心臟、血管、子宮及離體神經(jīng)肌肉制備等，單一地考察***對(duì)某一部分的作用。深入研究還包括細(xì)胞水平、分子水平的分析研究。 </p> <p> <br /> 綜合法是指在整體動(dòng)物身上進(jìn)行，是在若干其它因素綜合參與下考察***作用。北京免疫原性毒理學(xué)安全性評(píng)價(jià)技術(shù)服務(wù)</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="北京免疫原性毒理學(xué)安全性評(píng)價(jià)技術(shù)服務(wù),毒理學(xué)安全性評(píng)價(jià)" src="http://tyunfile.71360.com/UploadFile/shchaorui/637129699835605469/3930676.png"></div><p> 產(chǎn)品類(lèi)別檢測(cè)項(xiàng)目食品（保健食品）食品（保健食品）急性經(jīng)口毒性試驗(yàn)(限量法)食品（保健食品）細(xì)菌回復(fù)突變?cè)囼?yàn)食品（保健食品）哺乳動(dòng)物紅細(xì)胞微核試驗(yàn)食品（保健食品）精母細(xì)胞染色體畸變?cè)囼?yàn)食品（保健食品）28天經(jīng)口毒性試驗(yàn)食品90天經(jīng)口毒性試驗(yàn)食品致畸試驗(yàn)化妝品化妝品皮膚刺激性/腐蝕性試驗(yàn)化妝品急性眼刺激性/腐蝕性試驗(yàn)化妝品皮膚***反應(yīng)試驗(yàn)皮膚光毒性試驗(yàn)化妝品急性經(jīng)皮毒性試驗(yàn)(限量法)化妝品鼠傷寒沙門(mén)氏菌／回復(fù)突變?cè)囼?yàn)化妝品體內(nèi)哺乳動(dòng)物細(xì)胞微核試驗(yàn)消毒產(chǎn)品消毒產(chǎn)品多次完整皮膚刺激試驗(yàn)消毒產(chǎn)品急性經(jīng)口毒性試驗(yàn)(限量法)消毒產(chǎn)品急性眼刺激試驗(yàn)消毒產(chǎn)品一次破損皮膚刺激試驗(yàn)消毒產(chǎn)品一次完整皮膚刺激試驗(yàn)消毒產(chǎn)品睪丸生殖細(xì)胞染色體畸變?cè)囼?yàn)消毒用品微核試驗(yàn)消毒產(chǎn)品急性吸入毒性試驗(yàn)一次使用衛(wèi)生用品一次使用衛(wèi)生用品多次皮膚刺激試驗(yàn)一次性使用衛(wèi)生用品皮膚***反應(yīng)試驗(yàn)一次性使用衛(wèi)生用品陰道黏膜刺激試驗(yàn)危險(xiǎn)廢物危險(xiǎn)廢物急性經(jīng)口毒性試驗(yàn)危險(xiǎn)廢物急性經(jīng)皮毒性試驗(yàn)危險(xiǎn)廢物急性吸入毒性試驗(yàn)化學(xué)品化學(xué)品急性經(jīng)口毒性試驗(yàn)化學(xué)品急性皮膚刺激性/腐蝕性試驗(yàn)化學(xué)品急性吸入毒性試驗(yàn)化學(xué)品急性經(jīng)皮毒性試驗(yàn)化學(xué)品皮膚致敏試驗(yàn)化學(xué)品急性眼刺激性/腐蝕性試。北京給藥毒理學(xué)安全性評(píng)價(jià)技術(shù)服務(wù)遺傳毒性，亞慢性和慢性毒性研究。</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="北京免疫原性毒理學(xué)安全性評(píng)價(jià)技術(shù)服務(wù),毒理學(xué)安全性評(píng)價(jià)" src="http://tyunfile.71360.com/UploadFile/shchaorui/637129699841435547/3737546.png"></div><p> 按照我國(guó)衛(wèi)生部《食品安全毒理學(xué)評(píng)價(jià)程序和檢驗(yàn)方法規(guī)范》，采用急性毒性試驗(yàn)、Ames試驗(yàn)、小鼠骨髓嗜多染紅細(xì)胞微核試驗(yàn)和小鼠精子畸形試驗(yàn)對(duì)植物甾醇作為食品添加劑和保健食品原料的食用安全性進(jìn)行評(píng)價(jià)。結(jié)果顯示：大、小鼠急性經(jīng)口LD50大于5 000 mg/kg，Ames試驗(yàn)、小鼠骨髓嗜多染紅細(xì)胞微核試驗(yàn)和小鼠精子畸形試驗(yàn)結(jié)果均為陰性。由此得出植物甾醇屬于實(shí)際***物，可以作為一種食品添加劑和保健食品原料進(jìn)行開(kāi)發(fā)、利用。 </p> <p> 關(guān)鍵詞：植物甾醇；安全性；毒理試驗(yàn)；Ames試驗(yàn)；微核試驗(yàn)；精子畸形試驗(yàn) </p>***代謝是指***在吸收過(guò)程或進(jìn)入體循環(huán)后，受腸道菌叢或體內(nèi)酶系統(tǒng)的作用，結(jié)構(gòu)發(fā)生轉(zhuǎn)變的過(guò)程稱(chēng)為代謝或生物轉(zhuǎn)化，其產(chǎn)物為代謝產(chǎn)物。 <p> 影響***代謝的因素1、給藥途徑：代謝與***代謝酶在體內(nèi)的分布以及局部***和組織的血流量有關(guān)。給藥途徑是影響***代謝的重要因素之一。 </p> <p> 2、給藥劑量和劑型：代謝與***代謝酶在體內(nèi)的分布以及局部***和組織以的血流量有關(guān)。給藥途徑是影響***代謝的重要因素之一。 </p> <p> 3、***的光學(xué)異構(gòu)特性的影響：***在體內(nèi)代謝反應(yīng)大多都是酶的反應(yīng)，因此，集體對(duì)***的代謝能力主要取決于體內(nèi)各種***代謝酶的活力和數(shù)量。 </p> <p> 4、酶抑或酶促作用：酶***劑是使代謝減慢的物質(zhì)，酶誘導(dǎo)劑是使代謝加快的物質(zhì)。非臨床安全性評(píng)價(jià)研究機(jī)構(gòu)，系指從事***非臨床研究的實(shí)驗(yàn)室。</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="北京免疫原性毒理學(xué)安全性評(píng)價(jià)技術(shù)服務(wù),毒理學(xué)安全性評(píng)價(jià)" src="http://tyunfile.71360.com/UploadFile/shchaorui/637129699842666016/4400715.png"></div><p style="text-indent:25px">食品安全性毒理學(xué)評(píng)價(jià)是運(yùn)用現(xiàn)代毒理學(xué)理論，并結(jié)合流行病學(xué)調(diào)查分析和闡明食品或食品中的特定物質(zhì)的毒性及其潛在危害，預(yù)測(cè)人體接觸后可能對(duì)人體健康產(chǎn)生影響的性質(zhì)和強(qiáng)度，提出食用安全風(fēng)險(xiǎn)和預(yù)防措施的一門(mén)技術(shù)。 [1] 相關(guān)法律法規(guī)編輯（1）《食品安全性毒理學(xué)評(píng)價(jià)程序》；（2）《農(nóng)藥安全性毒理學(xué)評(píng)價(jià)程序》；（3）《新藥（西藥）毒理學(xué)研究指導(dǎo)原則》；（4）《化妝品安全性評(píng)價(jià)程序和方法》；（5）《食品功能毒理學(xué)評(píng)價(jià)程序和檢驗(yàn)方法》；（6）《食品毒理學(xué)實(shí)驗(yàn)室操作規(guī)范》。新藥研究過(guò)程大致可分三步，即臨床前研究、臨床研究和售后調(diào)研。北京免疫原性毒理學(xué)安全性評(píng)價(jià)技術(shù)服務(wù)</p><p style="text-indent:25px">觀測(cè)組織形態(tài)學(xué)變化，如血細(xì)胞大小、甲狀腺大小、腎上腺皮質(zhì)萎縮等。北京免疫原性毒理學(xué)安全性評(píng)價(jià)技術(shù)服務(wù)</p><p style="text-indent:25px">生殖毒性需要考察隊(duì)動(dòng)物成年期和從受孕到幼仔性成熟的發(fā)育各階段的給藥影響，測(cè)定出給藥所致的速發(fā)和遲發(fā)效應(yīng)，其觀察應(yīng)持續(xù)一個(gè)完整的生命周期，即從某一代的受孕到其下一代受孕的時(shí)間周期。通常將生命周期分成以下幾個(gè)階段:A從交配前到受孕 (成年雄性和雌性生殖功能、配子的發(fā)育和成熟、交配行為、受精) ;B從受孕到著床 (成年雌性生殖功能、著床前發(fā)育、著床) ;C從著床到硬腭閉合 (成年雌性生殖功能、胚胎發(fā)育、主要***形成) ;D從硬腭閉合到妊娠終止 (成年雌性生殖功能、胎仔發(fā)育和生長(zhǎng)、***發(fā)育和生長(zhǎng)) ;E從出生到離乳 (成年雌性生殖功能、幼仔對(duì)宮外生活的適應(yīng)性、離乳前發(fā)育和生長(zhǎng)) ;F從離乳到性成熟 (離乳后發(fā)育和生長(zhǎng)、**生活的適應(yīng)能力、達(dá)到性成熟的情況) 。北京免疫原性毒理學(xué)安全性評(píng)價(jià)技術(shù)服務(wù)</p><p style="text-indent:25px">上海朝瑞生物科技有限公司總部位于上海市松江區(qū)廣富林路697號(hào)昂立大廈2113室，是一家1.發(fā)布科研技術(shù) 2.發(fā)布應(yīng)用技術(shù) 3.發(fā)布專(zhuān)業(yè)專(zhuān)長(zhǎng) 4.發(fā)布科研成果 5.發(fā)布我的需求 6.發(fā)布篩選檢驗(yàn)檢測(cè)服務(wù) 7.發(fā)布協(xié)同代研發(fā)服務(wù) 8.發(fā)布升級(jí)改造產(chǎn)品服務(wù) 9.發(fā)布實(shí)驗(yàn)室及儀器設(shè)備共享 10.發(fā)布培訓(xùn)基地共享 11.發(fā)布工廠代加工及共享車(chē)間 12.發(fā)布科研/項(xiàng)目團(tuán)隊(duì)招聘13.發(fā)布研究生婚戀 14.發(fā)布項(xiàng)目整包服務(wù) 15.發(fā)布資源交換業(yè)務(wù)的公司。上海朝瑞科技作為1.發(fā)布科研技術(shù) 2.發(fā)布應(yīng)用技術(shù) 3.發(fā)布專(zhuān)業(yè)專(zhuān)長(zhǎng) 4.發(fā)布科研成果 5.發(fā)布我的需求 6.發(fā)布篩選檢驗(yàn)檢測(cè)服務(wù) 7.發(fā)布協(xié)同代研發(fā)服務(wù) 8.發(fā)布升級(jí)改造產(chǎn)品服務(wù) 9.發(fā)布實(shí)驗(yàn)室及儀器設(shè)備共享 10.發(fā)布培訓(xùn)基地共享 11.發(fā)布工廠代加工及共享車(chē)間 12.發(fā)布科研/項(xiàng)目團(tuán)隊(duì)招聘13.發(fā)布研究生婚戀 14.發(fā)布項(xiàng)目整包服務(wù) 15.發(fā)布資源交換業(yè)務(wù)的企業(yè)之一，為客戶(hù)提供良好的科研技術(shù)服務(wù)，應(yīng)用技術(shù)服務(wù)，科研成果轉(zhuǎn)化，科學(xué)產(chǎn)品銷(xiāo)售。上海朝瑞科技繼續(xù)堅(jiān)定不移地走高質(zhì)量發(fā)展道路，既要實(shí)現(xiàn)基本面穩(wěn)定增長(zhǎng)，又要聚焦關(guān)鍵領(lǐng)域，實(shí)現(xiàn)轉(zhuǎn)型再突破。上海朝瑞科技始終關(guān)注化工行業(yè)。滿(mǎn)足市場(chǎng)需求，提高產(chǎn)品價(jià)值，是我們前行的力量。</p></p><br /><p>文章來(lái)源地址: http://www.cdcfah.com/cp/1247524.html</p></div></div></div></div></div><div id="gecqgmc" class="page-right twoColRt"><div id="gec2g2o" class="box01 margin10 clearfix"><h3><a href="http://www.cdcfah.com/cp/">猜你喜歡</a></h3><div id="oci2e0y" class="recomPic likePro"><a href="http://www.cdcfah.com/cp/814588.html"><div><img src="http://tyunfile.71360.com/UpLoadFile/2019/11/1/14/637082168864691056_lgpj_5374157.jpg" alt="福建ZF配件哪家強(qiáng) 信息推薦自業(yè)物資供應(yīng)" class="vcenter" onerror="javascript:this.src='/static/new_net_01/images/nopic.jpg';"></div><p>福建ZF配件哪家強(qiáng) 信息推薦自業(yè)物資供應(yīng)</p></a></div><div id="msymcqo" class="recomPic likePro"><a 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