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id="8jqip4p" class="content"><p><span>需求數(shù)量：</span>0</p><p><span>價格要求：</span>面議</p><p><span>所在地：</span>上海市</p><p><span>包裝要求：</span><span style="color: #f30;"></span></p><p><span>產(chǎn)品關(guān)鍵詞：</span>江蘇致畸毒理學(xué)安全性評價,毒理學(xué)安全性評價</p><p><span>***更新：</span>2020-09-13 02:04:17</p><p><span id="click" >瀏覽次數(shù)：0次</span></p><a rel="nofollow" class="button">聯(lián)系我們</a></div></div><div id="gp89vof" class="rightbox"><h3>公司基本資料信息</h3><p style="border:0;"><a rel="nofollow">上海朝瑞生物科技有限公司</a></p><p><span>聯(lián)系人：</span>仲先生</p><p><span>郵箱: </span>scienceladder@163.com</p><p><span>電話: </span>18621867065</p><p><span>傳真: </span>021_</p><p><span>網(wǎng)址: </span></p><p><span>手機(jī): </span>021-54133071</p><p><span>地址: </span>上海市松江區(qū)廣富林路697號昂立大廈2113室</p><p>[當(dāng)前離線] <a rel="nofollow"> [加為商友] </a><a rel="nofollow"> [發(fā)送信件] </a></p></div></div><div id="thj8lcz" class="page-proshow02"><p class="title">詳細(xì)說明</p><div id="d8h3egd" class="box"><p><p> 毒理學(xué)安全性評價的基本內(nèi)容文章來源：華道顧問編輯：華道顧問安全性——在規(guī)定條件下化學(xué)物被暴露對人體和人群不引起監(jiān)看共有還作用的實際確定性安全性評價——利用規(guī)定的毒理學(xué)程序和方法評價化學(xué)物對機(jī)體產(chǎn)生有害效應(yīng)（損傷、疾病或死亡），并外推和評價在規(guī)定條件下化學(xué)物暴露對人體和人群的健康是否安全。毒理學(xué)安全性評價的基本內(nèi)容⑴毒理學(xué)試驗前的準(zhǔn)備工作⑵不同階段的毒理學(xué)試驗項目***階段試驗——包括急性毒性試驗和局部毒性試驗，主要是測定LD50，江蘇致畸毒理學(xué)安全性評價、LC50或其近似值，為其他試驗的劑量設(shè)計提供參數(shù)，根據(jù)毒作用的性質(zhì)、特點(diǎn)推測靶***，并對受試物的急性毒性進(jìn)行分級第二階段試驗——包括重復(fù)計量毒性試驗、遺傳毒性試驗與發(fā)育毒性試驗，目的是了解受試物與機(jī)體多次暴露后可能造成的潛在危害，并研究受試物是否具有遺傳毒性與發(fā)育毒性第三階段試驗——包括亞慢性毒性試驗、生殖毒性試驗和毒動學(xué)試驗。亞慢性毒性試驗是為了確定較長時間內(nèi)重復(fù)暴露受試物所引起的毒效應(yīng)強(qiáng)度的性質(zhì)、靶***及可逆性，得到亞慢性暴露的LOAEL和NOAEL，江蘇致畸毒理學(xué)安全性評價，預(yù)測對人體健康的危害性。生殖毒性試驗觀察受試物對生殖過程的有害影響。局部毒性試驗，江蘇致畸毒理學(xué)安全性評價、免疫原性試驗、依賴性試驗、毒代動力學(xué)試驗及與評價***安全性有關(guān)的其它試驗。江蘇致畸毒理學(xué)安全性評價</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="江蘇致畸毒理學(xué)安全性評價,毒理學(xué)安全性評價" src="http://tyunfile.71360.com/UploadFile/shchaorui/637129699844843750/4385430.png"></div><p style="text-indent:25px">生殖毒性需要考察隊動物成年期和從受孕到幼仔性成熟的發(fā)育各階段的給藥影響，測定出給藥所致的速發(fā)和遲發(fā)效應(yīng)，其觀察應(yīng)持續(xù)一個完整的生命周期，即從某一代的受孕到其下一代受孕的時間周期。通常將生命周期分成以下幾個階段:A從交配前到受孕 (成年雄性和雌性生殖功能、配子的發(fā)育和成熟、交配行為、受精) ;B從受孕到著床 (成年雌性生殖功能、著床前發(fā)育、著床) ;C從著床到硬腭閉合 (成年雌性生殖功能、胚胎發(fā)育、主要***形成) ;D從硬腭閉合到妊娠終止 (成年雌性生殖功能、胎仔發(fā)育和生長、***發(fā)育和生長) ;E從出生到離乳 (成年雌性生殖功能、幼仔對宮外生活的適應(yīng)性、離乳前發(fā)育和生長) ;F從離乳到性成熟 (離乳后發(fā)育和生長、**生活的適應(yīng)能力、達(dá)到性成熟的情況) 。江蘇致畸毒理學(xué)安全性評價唐代的《新修本草》，是我國***部藥典，收載***884種。</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="江蘇致畸毒理學(xué)安全性評價,毒理學(xué)安全性評價" src="http://tyunfile.71360.com/UploadFile/shchaorui/637129699851884766/1874696.png"></div><p> 展開全部食品安全性毒理學(xué)評價程序包括四個階段，即急性毒性試驗，蓄積毒性和致突變試驗，亞慢性毒性（包括繁殖、致畸）試驗和代謝試驗，慢性毒性（包括致*）試驗。Ames試驗的常規(guī)方法有斑點(diǎn)試驗和平板摻入試驗兩種，具體操作如下：1、斑點(diǎn)試驗；吸取測試菌增菌培養(yǎng)后的菌液，注入融化并保溫45℃左右的上層軟瓊脂中，需S9活化的再加－，立即混勻，傾于底平板上，鋪平冷凝。用***尖頭鑷夾***圓濾紙片邊緣，紙片浸濕受試物溶液，或直接取固態(tài)受試物，貼放于上層培養(yǎng)基的表面。同時做溶劑對照和陽性對照，分別貼放于平板上相應(yīng)位置。平皿倒置于37℃溫箱培養(yǎng)48h。在紙片**長出密集菌落圈，為陽性；菌落散布，密度與自發(fā)回變相似，為陰性。3．平板摻入試驗:將一定量樣液和，需代謝活化的再加－S9mix，混勻后迅速傾于底平板上鋪平冷凝。同時做陰性和陽性對照，每種處理做3個平行。試樣通常設(shè)4個～5個劑量。選擇劑量范圍開始應(yīng)大些，有陽性或可疑陽性結(jié)果時，再在較窄的劑量范圍內(nèi)確定劑量反應(yīng)關(guān)系。培養(yǎng)同上。同一劑量各皿回變菌落均數(shù)與各陰性對照皿自發(fā)回變菌落均數(shù)之比，為致變比（MR）。MR值≥2，且有劑量-反應(yīng)關(guān)系，背景正常，則判為致突變陽性。</p><p> 新藥的藥效學(xué)研究主要指對bai其藥理作用的觀測和作用機(jī)理的探討。內(nèi)容du包括： </p> <p> （一）觀測zhi生理機(jī)能的改變。如新藥對***系統(tǒng)產(chǎn)生興奮還是***；對心肌收縮力或胃腸道運(yùn)動是加強(qiáng)還是減弱；對血管或支氣管是擴(kuò)張還是收縮等。 </p> <p> （二）測定生化指標(biāo)的變化，如血糖、電解質(zhì)；生理活性物質(zhì)，如血管緊張素、前列腺素、環(huán)磷苷濃度的改變等。 </p> <p> （三）觀測組織形態(tài)學(xué)變化，如血細(xì)胞大小、甲狀腺大小、腎上腺皮質(zhì)萎縮等。 </p> <p> 二、藥效學(xué)研究的目的 </p> <p> 主要達(dá)到二個目的：一是確定***的***作用，二是確定***的一般藥理作用。為新藥臨床試驗提供可靠依據(jù)。 </p> <p> 三、基礎(chǔ)藥效學(xué)研究方法 </p> <p> 藥效學(xué)研究方法很多，概括講可分綜合和分析法。所謂綜合法是指在整體動物身上進(jìn)行，是在若干其它因素綜合參與下考察***作用，根據(jù)實驗動物情況不同，可分為正常動物法和實驗***法。所謂分析方法是采用離體臟器，例如離體腸管、離體心臟、血管、子宮及離體神經(jīng)肌肉制備等，單一地考察***對某一部分的作用。深入研究還包括細(xì)胞水平、分子水平的分析研究。 </p> <p> <br /> 發(fā)育和生殖毒性試驗，致*性研究。</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="江蘇致畸毒理學(xué)安全性評價,毒理學(xué)安全性評價" src="http://tyunfile.71360.com/UploadFile/shchaorui/637129699841435547/3737546.png"></div><p style="text-indent:25px">病理檢查 (pathological examination) 已經(jīng)大量應(yīng)用于臨床工作及科學(xué)研究。在臨床方面主要進(jìn)行尸體病理檢查及手術(shù)病理檢查。手術(shù)病理檢查的目的，一是為了明確診斷及驗證術(shù)前的診斷，提高臨床的診斷水平；二是診斷明確后，可決定下步***方案及估計預(yù)后，進(jìn)而提高臨床的***水平。通過臨床病理分析，也可獲得大量極有價值的科研資料。單純形態(tài)學(xué)觀察進(jìn)行病理診斷的方法，即純定性的方法、形態(tài)學(xué)的方法*能進(jìn)行粗略的定量估計，如根據(jù)瘤細(xì)胞的核分裂數(shù)目，尤其是病理性核分裂來判斷惡性**的惡性變。20世紀(jì)90年代病理檢查進(jìn)入組化、免疫組化、分子生物學(xué)及*基因檢查。隨著自然科學(xué)的迅速發(fā)展，新儀器設(shè)備和技術(shù)應(yīng)用到醫(yī)學(xué)中來，超微結(jié)構(gòu)病理、分子病理學(xué)、免疫病理學(xué)、遺傳病理學(xué)等方法也都應(yīng)用到病理檢查中。觀測生理機(jī)bai能的改變。如新藥對***系統(tǒng)產(chǎn)生興奮還是***。江蘇致畸毒理學(xué)安全性評價</p><p style="text-indent:25px">體外試驗技術(shù)在***安全性評價中的應(yīng)用。江蘇致畸毒理學(xué)安全性評價</p><p> 食品安全性毒理學(xué)評價試驗的內(nèi)容包括哪些? </p> <p> <br /> </p> <p> 食品安全性毒理學(xué)評價試驗的四個階段： </p> <p> （1）急性毒性試驗： </p> <p> ①用霍恩氏、幾率單位法或寇氏法測定經(jīng)口LD50，如劑量達(dá)10g/kgB.w.，仍不引起動物死亡，則不必測定LD50； </p> <p> ②7天喂養(yǎng)試驗。 </p> <p> （2）蓄積毒性和致突變試驗： </p> <p> ①分別用蓄積系數(shù)法和20天試驗法進(jìn)行蓄積毒性試驗； </p> <p> ②致突變試驗包括細(xì)菌致突變試驗，微核試驗和骨髓細(xì)胞染色體畸變分析試驗中任一項，顯性致死試驗、睪丸生殖細(xì)胞染色體畸變分析試驗和精子畸形試驗中任一項，以及DNA修復(fù)合成試驗。 </p> <p> （3）亞慢性毒性和代謝試驗： </p> <p> ①亞慢性毒性試驗包括90天喂養(yǎng)試驗、喂養(yǎng)繁殖試驗、喂養(yǎng)致畸試驗和傳統(tǒng)致畸試驗； </p> <p> ②代謝試驗包括胃腸道吸收，測定血液濃度并計算生物半減期和其他動力學(xué)指標(biāo)，主要***和組織中的分布，排泄（尿、糞、膽汁）。有條件時可進(jìn)一步進(jìn)行代謝產(chǎn)物的分離和鑒定。 </p> <p> （4）慢性毒性試驗：將兩年慢性毒性試驗和致*試驗結(jié)合在一個動物試驗中進(jìn)行。 </p> <p> <br /> 江蘇致畸毒理學(xué)安全性評價</p><p style="text-indent:25px">上海朝瑞生物科技有限公司總部位于上海市松江區(qū)廣富林路697號昂立大廈2113室，是一家1.發(fā)布科研技術(shù) 2.發(fā)布應(yīng)用技術(shù) 3.發(fā)布專業(yè)專長 4.發(fā)布科研成果 5.發(fā)布我的需求 6.發(fā)布篩選檢驗檢測服務(wù) 7.發(fā)布協(xié)同代研發(fā)服務(wù) 8.發(fā)布升級改造產(chǎn)品服務(wù) 9.發(fā)布實驗室及儀器設(shè)備共享 10.發(fā)布培訓(xùn)基地共享 11.發(fā)布工廠代加工及共享車間 12.發(fā)布科研/項目團(tuán)隊招聘13.發(fā)布研究生婚戀 14.發(fā)布項目整包服務(wù) 15.發(fā)布資源交換業(yè)務(wù)的公司。上海朝瑞科技深耕行業(yè)多年，始終以客戶的需求為向?qū)В瑸榭蛻籼峁?**的科研技術(shù)服務(wù)，應(yīng)用技術(shù)服務(wù)，科研成果轉(zhuǎn)化，科學(xué)產(chǎn)品銷售。上海朝瑞科技繼續(xù)堅定不移地走高質(zhì)量發(fā)展道路，既要實現(xiàn)基本面穩(wěn)定增長，又要聚焦關(guān)鍵領(lǐng)域，實現(xiàn)轉(zhuǎn)型再突破。上海朝瑞科技創(chuàng)始人仲緒軍，始終關(guān)注客戶，創(chuàng)新科技，竭誠為客戶提供良好的服務(wù)。</p></p><br /><p>文章來源地址: http://www.cdcfah.com/cp/1259040.html</p></div></div></div></div></div><div id="aeg2egn" class="page-right twoColRt"><div id="y8is2mg" class="box01 margin10 clearfix"><h3><a href="http://www.cdcfah.com/cp/">猜你喜歡</a></h3><div id="lfm3el2" class="recomPic likePro"><a href="http://www.cdcfah.com/cp/814588.html"><div><img src="http://tyunfile.71360.com/UpLoadFile/2019/11/1/14/637082168864691056_lgpj_5374157.jpg" alt="福建ZF配件哪家強(qiáng) 信息推薦自業(yè)物資供應(yīng)" class="vcenter" onerror="javascript:this.src='/static/new_net_01/images/nopic.jpg';"></div><p>福建ZF配件哪家強(qiáng) 信息推薦自業(yè)物資供應(yīng)</p></a></div><div id="vuwncqc" class="recomPic likePro"><a 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