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href="http://www.cdcfah.com/cp/second-_nongye/">農(nóng)業(yè)</a>?<a href="http://www.cdcfah.com/cp/third-nongye_nlmyxmhz/">農(nóng)林牧漁項(xiàng)目合作</a>?北京能源微生物菌種定向改良生產(chǎn)性狀歡迎來電上海朝瑞生物科技供應(yīng)</p><div id="7ulxjc3" class="leftbox clearfix"><h1>北京能源微生物菌種定向改良生產(chǎn)性狀歡迎來電上海朝瑞生物科技供應(yīng)</h1><div id="qy8h3rn" class="proBig"><div id="gof3ziq" class="bigimg"><div><p class="pic"><img src="http://tyunfile.71360.com/UploadFile/shchaorui/637190230318886718/8257103.png" class="vcenter" onerror="javascript:this.src='/static/new_net_01/images/nopic.jpg';"></p></div></div><div id="nqr52de" class="smallimg"><div><p class="pic"><img src="http://tyunfile.71360.com/UploadFile/shchaorui/637190230318886718/8257103.png" class="vcenter" onerror="javascript:this.src='/static/new_net_01/images/nopic.jpg';"></p></div></div></div><div id="f3rvbfl" class="content"><p><span>需求數(shù)量：</span>0</p><p><span>價(jià)格要求：</span>面議</p><p><span>所在地：</span>上海市</p><p><span>包裝要求：</span><span style="color: #f30;"></span></p><p><span>產(chǎn)品關(guān)鍵詞：</span>北京能源微生物菌種定向改良生產(chǎn)性狀</p><p><span>***更新：</span>2020-06-04 00:24:30</p><p><span id="click" >瀏覽次數(shù)：0次</span></p><a rel="nofollow" class="button">聯(lián)系我們</a></div></div><div id="cfgpqrs" class="rightbox"><h3>公司基本資料信息</h3><p style="border:0;"><a rel="nofollow">上海朝瑞生物科技有限公司</a></p><p><span>聯(lián)系人：</span>仲先生</p><p><span>郵箱: </span>scienceladder@163.com</p><p><span>電話: </span>18621867065</p><p><span>傳真: </span>021_</p><p><span>網(wǎng)址: </span></p><p><span>手機(jī): </span>021-54133071</p><p><span>地址: </span>上海市松江區(qū)廣富林路697號(hào)昂立大廈2113室</p><p>[當(dāng)前離線] <a rel="nofollow"> [加為商友] </a><a rel="nofollow"> [發(fā)送信件] </a></p></div></div><div id="wzae7ie" class="page-proshow02"><p class="title">詳細(xì)說明</p><div id="j8qzzqb" class="box"><p><p> 鏈霉菌分子生物學(xué)研究組研究內(nèi)容：微生物發(fā)育分化和微生物次生代謝的分子調(diào)控。以鏈霉菌為模式系統(tǒng)，研究發(fā)育分化中基因的時(shí)空表達(dá)及其作用的分子機(jī)制，為揭示生命現(xiàn)象的基本規(guī)律提供理論依據(jù)。研究微生物次生代謝的生物合成途徑及其基因的特異調(diào)控和全局調(diào)控，為定向改良生產(chǎn)菌的生產(chǎn)能力和獲得新的代謝產(chǎn)物提供理論指導(dǎo)。承擔(dān)課題：國家自然科學(xué)基金重點(diǎn)項(xiàng)目"原核生物發(fā)育與分化"；國家自然科學(xué)基金面上項(xiàng)目"乳酸乳球菌食品級(jí)基因克隆表達(dá)系統(tǒng)的研究"和"與鏈霉菌分化有關(guān)的調(diào)控基因scrX的結(jié)構(gòu)及調(diào)控機(jī)理研究"；國家杰出青年科學(xué)基金"圈卷產(chǎn)色鏈霉菌尼可霉素生物合成基因簇的克隆及序列分析"；國際合作項(xiàng)目"微生物活性物質(zhì)的生物轉(zhuǎn)化"；中科院重要方向"嗜鹽菌遺傳轉(zhuǎn)化系列的構(gòu)建及其應(yīng)用"。研究進(jìn)展：研究了與鏈霉菌發(fā)育和分化有關(guān)的重要基因-scrX和samR及，北京能源微生物菌種定向改良生產(chǎn)性狀，該基因的阻斷，使鏈霉菌的發(fā)育停止在氣生菌絲階段。samR在鏈霉菌發(fā)育的早期有重要作用，北京能源微生物菌種定向改良生產(chǎn)性狀，主要在鏈霉菌從基質(zhì)菌絲到氣生菌絲形成的發(fā)育轉(zhuǎn)變中起調(diào)控作用。完成了尼可霉素生物合成全部基因簇的DNA序列分析，北京能源微生物菌種定向改良生產(chǎn)性狀，結(jié)果揭示在35kb的DNA序列中含有26個(gè)基因，這些基因已送GenBank登錄，大部分是未見報(bào)道的新基因。</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="北京能源微生物菌種定向改良生產(chǎn)性狀" src="http://tyunfile.71360.com/UploadFile/shchaorui/637190230318886718/8257103.png"></div><p> 研究內(nèi)容:主要以酵母菌為材料，構(gòu)建作為基因克隆及表達(dá)的優(yōu)良受體和載體系統(tǒng)并開展基因表達(dá)調(diào)控研究。同時(shí)進(jìn)行酵母細(xì)胞自溶機(jī)理研究。在應(yīng)用基礎(chǔ)研究方面：采用誘變、雜交、融合及基因工程等育種方法，對(duì)有應(yīng)用前景的酵母菌進(jìn)行遺傳育種，選育具有生產(chǎn)價(jià)值的優(yōu)良酵母菌種。 </p> <p> 承擔(dān)課題：國家"九五"攻關(guān)項(xiàng)目"酵母發(fā)酵法生產(chǎn)麥角固醇"；國家自然科學(xué)基金面上項(xiàng)目"絮凝性強(qiáng)及熟化期短的啤酒酵母工程菌的研究"；橫向合作項(xiàng)目"熟化期短及絮凝性強(qiáng)的啤酒酵母工程菌的構(gòu)建"。 </p> <p> 研究進(jìn)展：選育到麥角固醇高產(chǎn)酵母菌株YEH－56，麥角固醇含量達(dá)細(xì)胞干重的3％。利用整合載體將醋酸桿菌α-乙酰乳酸脫羧酶基因整合到青島啤酒酵母菌中并獲得表達(dá),目前正在進(jìn)行中試實(shí)驗(yàn)。分離到低滲透敏感突變株和溫度敏感突變株，它們?cè)诘蜐B透介質(zhì)中或高溫下表現(xiàn)出細(xì)胞自溶特性。 </p> <p> 主要成果：本年度在國內(nèi)外有關(guān)刊物發(fā)表論文5篇，其中SCI收錄刊物論文1篇。 </p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="北京能源微生物菌種定向改良生產(chǎn)性狀" src="http://tyunfile.71360.com/UploadFile/shchaorui/637190230317294922/2104477.png"></div><p> 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