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onerror="javascript:this.src='/static/new_net_01/images/nopic.jpg';"></p></div></div><div id="pl7nbfj" class="smallimg"><div><p class="pic"><img src="http://tyunfile.71360.com/UploadFile/shchaorui/637123969947460937/5782493.png" class="vcenter" onerror="javascript:this.src='/static/new_net_01/images/nopic.jpg';"></p></div></div></div><div id="dt5zfdr" class="content"><p><span>需求數(shù)量：</span>0</p><p><span>價(jià)格要求：</span>面議</p><p><span>所在地：</span>上海市</p><p><span>包裝要求：</span><span style="color: #f30;"></span></p><p><span>產(chǎn)品關(guān)鍵詞：</span>北京高純Claudin18.2蛋白產(chǎn)品介紹</p><p><span>***更新：</span>2020-06-05 08:11:29</p><p><span id="click" >瀏覽次數(shù)：0次</span></p><a rel="nofollow" class="button">聯(lián)系我們</a></div></div><div id="ljzhnl7" class="rightbox"><h3>公司基本資料信息</h3><p style="border:0;"><a rel="nofollow">上海朝瑞生物科技有限公司</a></p><p><span>聯(lián)系人：</span>仲先生</p><p><span>郵箱: </span>scienceladder@163.com</p><p><span>電話: </span>18621867065</p><p><span>傳真: </span>021_</p><p><span>網(wǎng)址: </span></p><p><span>手機(jī): </span>021-54133071</p><p><span>地址: </span>上海市松江區(qū)廣富林路697號(hào)昂立大廈2113室</p><p>[當(dāng)前離線] <a rel="nofollow"> [加為商友] </a><a rel="nofollow"> [發(fā)送信件] </a></p></div></div><div id="pd57rh5" class="page-proshow02"><p class="title">詳細(xì)說(shuō)明</p><div id="b7nbrzz" class="box"><p><p> 2019年圣安東尼奧乳腺*研討會(huì)（SABCS）于12月10-14日在圣安東尼奧舉行。本次大會(huì)上，復(fù)旦大學(xué)附屬**醫(yī)院乳腺外科李俊杰教授口頭報(bào)告了一項(xiàng)三陰性乳腺*術(shù)后輔助化療臨床研究（CBCSG-010）隨訪5年的**終結(jié)果。醫(yī)脈通有幸在大會(huì)現(xiàn)場(chǎng)邀請(qǐng)李俊杰教授對(duì)該研究進(jìn)行介紹和深度解讀，詳情如下。李俊杰教授復(fù)旦大學(xué)附屬**醫(yī)院乳腺外科副主任醫(yī)師醫(yī)學(xué)博士中國(guó)***協(xié)會(huì)乳腺*專(zhuān)業(yè)委員會(huì)青委中華醫(yī)學(xué)會(huì)乳腺**學(xué)組青委上海市***協(xié)會(huì)乳腺*專(zhuān)業(yè)委員會(huì)**及秘書(shū)長(zhǎng)JCO中文版青年**等職務(wù)中華乳腺病雜志中青年編委研究背景三陰性乳腺*（TNBC）約占全部乳腺*的10%～25%，多見(jiàn)于年輕女性。TNBC異質(zhì)性強(qiáng)，惡性程度高，診斷時(shí)原發(fā)**較大，組織分級(jí)高，腋窩淋巴結(jié)轉(zhuǎn)移者較多，同時(shí)侵襲性強(qiáng)，遠(yuǎn)處轉(zhuǎn)移常見(jiàn)，北京高純Claudin18.2蛋白產(chǎn)品介紹，術(shù)后3年內(nèi)早期復(fù)發(fā)風(fēng)險(xiǎn)高。TNBC患者的ER、PR、HER2均陰性，化療仍是比較好的全身***手段。根據(jù)NCCN指南以及StGallen乳腺*共識(shí)，北京高純Claudin18，北京高純Claudin18.2蛋白產(chǎn)品介紹.2蛋白產(chǎn)品介紹，蒽環(huán)類(lèi)聯(lián)合紫衫類(lèi)***的化療方案是標(biāo)準(zhǔn)的輔助***策略。如何優(yōu)化化療的應(yīng)用是TNBC研究領(lǐng)域的重要課題之一。一部分臨床研究嘗試調(diào)整蒽環(huán)和紫杉類(lèi)***的劑量，探索密集或增量減量應(yīng)用的療效優(yōu)化；還有一部分臨床研究探索在蒽環(huán)和紫杉類(lèi)基礎(chǔ)上聯(lián)合其他***。</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="北京高純Claudin18.2蛋白產(chǎn)品介紹" src="http://tyunfile.71360.com/UploadFile/shchaorui/637123969947460937/5782493.png"></div><p> 密蛋白（Claudin)是上皮與內(nèi)皮的緊密連接內(nèi)的整合膜蛋白（Integral Membrane Protein)。密蛋白18(CLDN18)分子是整合跨膜蛋白（四次跨膜蛋白)，其具有四個(gè)跨膜疏水區(qū)和兩個(gè)胞外環(huán)。CLDN18以?xún)煞N不同剪接變體存在， CLDN18.1,和CLDN18.2。剪接變體CLDN18.1和CLDN18.2在包含***個(gè)跨膜（TM)區(qū)和環(huán)1的N端部分中存在差異，而C端的蛋白質(zhì)一級(jí)序列相同。 </p> <p> CLDN18.1在正常肺的細(xì)胞中選擇性表達(dá)，而CLDN18.2*在胃細(xì)胞上表達(dá)。但是，CLDN18.2在正常胃中的表達(dá)局限于已分化的胃上皮短壽細(xì)胞中。已確認(rèn)，CLDN18.2在多種 **組織中表達(dá)。<span style="font-size:12px;">。</span> </p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="北京高純Claudin18.2蛋白產(chǎn)品介紹" src="http://tyunfile.71360.com/UploadFile/shchaorui/637123969950605469/9979953.png"></div><p style="text-indent:25px">Claudin是由日本科學(xué)家Shoichiro Tsukita所發(fā)現(xiàn)，當(dāng)初發(fā)現(xiàn)Claudin和**沒(méi)有什么關(guān)系。Tsukita對(duì)細(xì)胞的基本運(yùn)作感興趣，于1993年發(fā)現(xiàn)一類(lèi)叫occludin的細(xì)胞粘合蛋白，以為解決了細(xì)胞粘合問(wèn)題。后來(lái)發(fā)現(xiàn)細(xì)胞敲除occludin仍會(huì)粘合，他們沒(méi)有放棄找到了隱藏更深的Claudin。不幸的是年*52歲的Tsukita于2005年死于胰腺*，死前4天此公還在實(shí)驗(yàn)室工作，他找到Claudin據(jù)說(shuō)也是用了日本科學(xué)家常用的brutal force戰(zhàn)術(shù)。制藥工業(yè)的真金白銀無(wú)疑是新藥不可或缺的一個(gè)因素，但沒(méi)有Tsukita這樣偉大科學(xué)家的貢獻(xiàn)新藥也無(wú)從談起?，F(xiàn)在IMAB362除了胃*也獲得奪去Tsukita生命的胰腺*孤兒藥地位。</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="北京高純Claudin18.2蛋白產(chǎn)品介紹" src="http://tyunfile.71360.com/UploadFile/shchaorui/637123969973388672/964933.png"></div></p><br /><p>文章來(lái)源地址: http://www.cdcfah.com/cp/153899.html</p></div></div></div></div></div><div id="fddjrxt" class="page-right twoColRt"><div id="nd5bhfb" class="box01 margin10 clearfix"><h3><a href="http://www.cdcfah.com/cp/">猜你喜歡</a></h3><div id="hntrpdr" class="recomPic likePro"><a 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