北京特異Claudin18.2蛋白推薦廠家歡迎來(lái)電上海朝瑞生物科技供應(yīng)-b2b網(wǎng)站_b2b電子商務(wù)平臺(tái)【買產(chǎn)品】-上?？谄蚴称酚邢薰?/title><meta name="description" content=" claudin-7基因是胃*中經(jīng)常表達(dá)上調(diào)的基因，使用免疫組化方法發(fā)現(xiàn)，小鼠和人類胃黏膜腺體不典型增生時(shí)，常過(guò)度表達(dá)clandin-7，而其周圍正常胃黏膜組織卻不表達(dá)。其在腸化、不典型增生和胃"><meta name="keywords" content="北京特異Claudin18.2蛋白推薦廠家"><link rel="canonical" href="http://www.cdcfah.com/"/><meta name="applicable-device" content="pc"><link rel="shortcut icon" href="/static/new_net_01/images/favicon.ico"><link rel="stylesheet" href="/static/new_net_01/css/slick.css" /><link rel="stylesheet" href="/static/new_net_01/css/addnew.css"><link rel="stylesheet" href="/static/new_net_01/css/sidenav.css"><link rel="stylesheet" href="/static/new_net_01/css/style.css" /><link rel="stylesheet" href="/static/new_net_01/css/tab.css"><link rel="stylesheet" href="/static/new_net_01/css/404.css"> <meta name="baidu-site-verification" content="OBVzrC9aaQ" /> <meta http-equiv="Cache-Control" 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clearfix"><h1>北京特異Claudin18.2蛋白推薦廠家歡迎來(lái)電上海朝瑞生物科技供應(yīng)</h1><div id="vhzfv57" class="proBig"><div id="ljxntll" class="bigimg"><div><p class="pic"><img src="http://tyunfile.71360.com/UploadFile/shchaorui/637123969973398437/93922.png" class="vcenter" onerror="javascript:this.src='/static/new_net_01/images/nopic.jpg';"></p></div></div><div id="bppfhpb" class="smallimg"><div><p class="pic"><img src="http://tyunfile.71360.com/UploadFile/shchaorui/637123969973398437/93922.png" class="vcenter" onerror="javascript:this.src='/static/new_net_01/images/nopic.jpg';"></p></div></div></div><div id="bj7zpfr" class="content"><p><span>需求數(shù)量：</span>0</p><p><span>價(jià)格要求：</span>面議</p><p><span>所在地：</span>上海市</p><p><span>包裝要求：</span><span style="color: #f30;"></span></p><p><span>產(chǎn)品關(guān)鍵詞：</span>北京特異Claudin18.2蛋白推薦廠家</p><p><span>***更新：</span>2020-06-05 11:14:36</p><p><span id="click" >瀏覽次數(shù)：0次</span></p><a rel="nofollow" class="button">聯(lián)系我們</a></div></div><div id="ht9jr9d" class="rightbox"><h3>公司基本資料信息</h3><p style="border:0;"><a rel="nofollow">上海朝瑞生物科技有限公司</a></p><p><span>聯(lián)系人：</span>仲先生</p><p><span>郵箱: </span>scienceladder@163.com</p><p><span>電話: </span>18621867065</p><p><span>傳真: </span>021_</p><p><span>網(wǎng)址: </span></p><p><span>手機(jī): </span>021-54133071</p><p><span>地址: </span>上海市松江區(qū)廣富林路697號(hào)昂立大廈2113室</p><p>[當(dāng)前離線] <a rel="nofollow"> [加為商友] </a><a rel="nofollow"> [發(fā)送信件] </a></p></div></div><div id="hjd1nrh" class="page-proshow02"><p class="title">詳細(xì)說(shuō)明</p><div id="xvbblnr" class="box"><p><p> claudin-7基因是胃*中經(jīng)常表達(dá)上調(diào)的基因，使用免疫組化方法發(fā)現(xiàn)，小鼠和人類胃黏膜腺體不典型增生時(shí)，常過(guò)度表達(dá)clandin-7，而其周圍正常胃黏膜組織卻不表達(dá)。其在腸化、不典型增生和胃*中表達(dá)陽(yáng)性率分別為30%、80%和70%，并且多在腸型胃*中表達(dá)。Park等通過(guò)免疫組化和Westemblot方法發(fā)現(xiàn)，北京特異Claudin18.2蛋白推薦廠家，claudin-7更常表達(dá)于腸化、腺瘤和胃*中，而在47%的正常胃黏膜中不表達(dá)，只有l(wèi)P/。的腸型胃*不表達(dá)claudin-7，而彌散型胃*不表達(dá)率達(dá)到41%，北京特異Claudin18.2蛋白推薦廠家。所以，研究人員認(rèn)為claudin-7的表達(dá)參與了胃*早期發(fā)展過(guò)程。Lkmi等在研究食道鱗*中發(fā)現(xiàn)，claudin-7的功能異常導(dǎo)致E-cadherin表達(dá)減少，從而增加了食道鱗*的侵襲性。用siRNA方法使食道鱗*細(xì)胞株中claudin-7失活，導(dǎo)致E-cadherin表達(dá)減少，北京特異Claudin18.2蛋白推薦廠家。由于在彌散型胃*中E-cadherin和claudin-7都較正常組織和腸型胃*明顯減少，推測(cè)在胃*中可能也存在這種機(jī)制。 </p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="北京特異Claudin18.2蛋白推薦廠家" src="http://tyunfile.71360.com/UploadFile/shchaorui/637123969973398437/93922.png"></div><p style="text-indent:25px"> 胃*在全球**死亡中位列第三，是一種難治性**，可選擇的靶向yaowu較少，靶向zhiliao的療效也欠佳，而且每年約有100萬(wàn)病例被確診。盡管外科手術(shù)和新化療方案均取得了很大的進(jìn)步，但是5年生存率大約只有5％-20％，晚期胃*患者的中位總生存期(OS)約為10個(gè)月。因此，尋找更有效的方法來(lái)延長(zhǎng)胃*患者的生命迫在眉睫。Claudin18.2（CLDN18.2）是一種胃特異性膜蛋白，被認(rèn)為是胃*和其他**類型的潛在zhiliao靶點(diǎn)，此靶點(diǎn)的發(fā)現(xiàn)也為胃*的zhiliao提供了一種新的選擇。</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="北京特異Claudin18.2蛋白推薦廠家" src="http://tyunfile.71360.com/UploadFile/shchaorui/637123969950605469/9979953.png"></div><p> 29日日本制藥企業(yè)安斯泰來(lái)宣布將以4.6億美元首付、9.6億潛在里程金收購(gòu)德國(guó)生物技術(shù)公司Ganymed。Ganymed的**資產(chǎn)Claudin18.2抗體IMAB362曾是今年ASCO的比較大。在胃*二期試驗(yàn)中比標(biāo)準(zhǔn)化療延長(zhǎng)生存期（13.2 對(duì)8.4 個(gè)月），在Claudin18.2高表達(dá)患者IMAB362優(yōu)勢(shì)更明顯（16.7 對(duì)9 個(gè)月）。 </p> <p> 安斯泰來(lái)2009年曾以6.5億的白菜價(jià)從Medivation收購(gòu)了前列腺* Xtandi的美國(guó)以外權(quán)益，今年Medivation以140億美元天價(jià)被輝瑞收購(gòu)，主要是因?yàn)閄tandi的潛在價(jià)值。 14億收購(gòu)一個(gè)二期臨床資產(chǎn)雖然看著不便宜，但I(xiàn)MAB362的療效非常好，而且有可靠的生物標(biāo)記，所以開(kāi)發(fā)風(fēng)險(xiǎn)較小。和**近其它**資產(chǎn)比這個(gè)價(jià)格還算偏低的。 </p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="北京特異Claudin18.2蛋白推薦廠家" src="http://tyunfile.71360.com/UploadFile/shchaorui/637123969977363281/5123419.png"></div></p><br /><p>文章來(lái)源地址: http://www.cdcfah.com/cp/156475.html</p></div></div></div></div></div><div id="tjftdtr" class="page-right twoColRt"><div id="xxrlztj" class="box01 margin10 clearfix"><h3><a href="http://www.cdcfah.com/cp/">猜你喜歡</a></h3><div id="fttlb77" class="recomPic likePro"><a href="http://www.cdcfah.com/cp/814588.html"><div><img src="http://tyunfile.71360.com/UpLoadFile/2019/11/1/14/637082168864691056_lgpj_5374157.jpg" alt="福建ZF配件哪家強(qiáng) 信息推薦自業(yè)物資供應(yīng)" class="vcenter" onerror="javascript:this.src='/static/new_net_01/images/nopic.jpg';"></div><p>福建ZF配件哪家強(qiáng) 信息推薦自業(yè)物資供應(yīng)</p></a></div><div id="px7fzhv" 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