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src="https://tyunfile.71360.com/UploadFile/tpswkj/637444036025168597/2680991.png" class="vcenter" onerror="javascript:this.src='/static/new_net_01/images/nopic.jpg';"></p></div></div><div id="qjda8uz" class="smallimg"><div><p class="pic"><img src="https://tyunfile.71360.com/UploadFile/tpswkj/637444036025168597/2680991.png" class="vcenter" onerror="javascript:this.src='/static/new_net_01/images/nopic.jpg';"></p></div></div></div><div id="c33odb3" class="content"><p><span>需求數(shù)量：</span>0</p><p><span>價(jià)格要求：</span>面議</p><p><span>所在地：</span>上海市</p><p><span>包裝要求：</span><span style="color: #f30;"></span></p><p><span>產(chǎn)品關(guān)鍵詞：</span>上海口腔微生物多樣性分析診斷,病毒宏基因組測(cè)序</p><p><span>***更新：</span>2021-01-28 04:20:07</p><p><span id="click" >瀏覽次數(shù)：0次</span></p><a rel="nofollow" class="button">聯(lián)系我們</a></div></div><div id="a3lqy30" class="rightbox"><h3>公司基本資料信息</h3><p style="border:0;"><a rel="nofollow">上海探普生物科技有限公司</a></p><p><span>聯(lián)系人：</span>喻利</p><p><span>郵箱: </span>380467011@qq.com</p><p><span>電話: </span>13166221237</p><p><span>傳真: </span>021_</p><p><span>網(wǎng)址: </span>http://www.tpbio.com.cn</p><p><span>手機(jī): </span>021-13166221</p><p><span>地址: </span>放鶴路1088號(hào)6號(hào)樓307</p><p>[當(dāng)前離線] <a rel="nofollow"> [加為商友] </a><a rel="nofollow"> [發(fā)送信件] </a></p></div></div><div id="i86shau" class="page-proshow02"><p class="title">詳細(xì)說明</p><div id="331c5br" class="box"><p><p style="text-indent:25px">病毒是引發(fā)人畜共患病的主要病原體之一，伴隨環(huán)境、生態(tài)和人類行為等各方面因素的變化，新發(fā)人畜共患病也呈現(xiàn)逐年遞增的趨勢(shì)，它們極大地威脅著人類和動(dòng)物的健康和生命，并給畜牧業(yè)和農(nóng)業(yè)的健康發(fā)展以及自然界生態(tài)鏈的平衡帶來危害及災(zāi)難。然而，許多新發(fā)人畜共患病的病原初往往是未知的，如1986年的牛海綿狀腦病、1999年的尼帕病毒、2003年的SARS冠狀病毒、1997至今不斷變異的高致病性禽流感H5和H；7，上?？谇晃⑸锒鄻有苑治鲈\斷、2009年的甲型H1N1，上?？谇晃⑸锒鄻有苑治鲈\斷、2010年的新型布尼亞病毒，它們都經(jīng)歷了一個(gè)從未知到己知的探索過程。為此，及早地發(fā)現(xiàn)，鑒別未知的或新出現(xiàn)的病原，是有效預(yù)防和控制傳染病的先決條件之一。傳統(tǒng)的診斷技術(shù)已不能滿足提前預(yù)警或快速診斷新發(fā)人畜共患病的需求。近年來，上?？谇晃⑸锒鄻有苑治鲈\斷，病毒宏基因組學(xué)的出現(xiàn)和興起，為人類診斷新發(fā)人畜共患病和探索潛在的病原提供了巨大的幫助。宏基因組檢測(cè)方法也面臨不少挑戰(zhàn)，檢測(cè)結(jié)果的靈敏度受宿主及其他微生物背景核酸的影響。上?？谇晃⑸锒鄻有苑治鲈\斷</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="上?？谇晃⑸锒鄻有苑治鲈\斷,病毒宏基因組測(cè)序" src="https://tyunfile.71360.com/UploadFile/tpswkj/637444036025168597/2680991.png"></div><p style="text-indent:25px">宏病毒組其實(shí)就是病毒的宏基因組（meta-genomics），該技術(shù)是隨著高通量測(cè)序技術(shù)的興起而發(fā)展起來的。該技術(shù)主要是使用大量微生物群體樣本的測(cè)序數(shù)據(jù)和生物信息學(xué)分析手段，以多種數(shù)據(jù)庫為基礎(chǔ)，進(jìn)行群體的種類和功能分析。因此，它主要的應(yīng)用場(chǎng)景在于微生物群體研究，如腸道微生物、皮膚微生物、口腔微生物、水體微生物、土壤微生物等。一直以來宏基因組技術(shù)都是在細(xì)菌領(lǐng)域使用，病毒的樣本收集困難、文庫構(gòu)建繁瑣、數(shù)據(jù)庫不完善，因此宏基因組技術(shù)未能獲得普遍應(yīng)用。上海探普生物科技有限公司立志專門解決病毒方向的基因組研究難題，開發(fā)了整套的樣本處理和生信分析流程，基于這套流程，研究者們想對(duì)樣本進(jìn)行宏病毒組測(cè)序就很容易實(shí)現(xiàn)了。四川腸道微生物多樣性測(cè)序找哪家隨著數(shù)據(jù)庫日趨完善，對(duì)樣本進(jìn)行宏病毒組測(cè)序以后，我們將獲得越來越豐富的信息。</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="上?？谇晃⑸锒鄻有苑治鲈\斷,病毒宏基因組測(cè)序" src="https://tyunfile.71360.com/UploadFile/tpswkj/637444035867179279/4154288.png"></div><p style="text-indent:25px">**狀病毒的發(fā)現(xiàn)，病原宏基因組測(cè)序功不可沒：對(duì)一種新病毒進(jìn)行鑒定和檢測(cè)，其中非常關(guān)鍵的步驟就是獲得病毒的全基因組信息。在此次**監(jiān)測(cè)和防控中，病原宏基因組測(cè)序發(fā)揮了至關(guān)重要的作用，利用其技術(shù)優(yōu)勢(shì)，研究人員在五天內(nèi)就鑒定并分析出的基因組，而2003年SARS的鑒定耗時(shí)5月余、2013年H7N9的鑒定耗時(shí)1月余。2019-nCoV為線性單鏈RNA（ssRNA）病毒，基因組全長包含29903個(gè)核苷酸，10個(gè)基因。病毒基因組序列為進(jìn)一步分析其傳染機(jī)理，傳播途徑，藥物靶點(diǎn)等提供了有利的支持。</p><p style="text-indent:25px">宏病毒組學(xué)(ViralMetagenomics)是宏基因組學(xué)的一個(gè)分支，但與傳統(tǒng)的宏基因組學(xué)概念不同，它是在宏基因組學(xué)概念的基礎(chǔ)上，結(jié)合病毒自身的特點(diǎn)，將宏基因組學(xué)方法應(yīng)用到病毒學(xué)領(lǐng)域而形成的。2002年，Breitbart等(BreitbartM,etal,2002)將宏基因組學(xué)方法應(yīng)用于海洋病毒群落的研究，發(fā)現(xiàn)噬菌體為海水中主要病毒組，這一研究標(biāo)志著宏病毒組學(xué)正式應(yīng)用于科學(xué)研究。簡而言之，宏病毒組學(xué)就是應(yīng)用特殊方法把特定環(huán)境中所有病毒與其他微生物分開，然后提取的病毒核酸，用高通量技術(shù)進(jìn)行病毒核酸測(cè)序，依托現(xiàn)有數(shù)據(jù)庫進(jìn)行相應(yīng)的比對(duì)工作，并運(yùn)用軟件分析處理后得到研究樣品中病毒群落的組成信息。上海探普生物科技有限公司對(duì)樣本進(jìn)行宏病毒組測(cè)序有什么優(yōu)勢(shì)？</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="上海口腔微生物多樣性分析診斷,病毒宏基因組測(cè)序" src="https://tyunfile.71360.com/UploadFile/tpswkj/637444036042554463/5535695.png"></div><p style="text-indent:25px">在運(yùn)用宏基因組測(cè)序方法檢測(cè)的樣本量位居全球前列，樣本總數(shù)居國內(nèi)第二，其中腦脊液檢測(cè)量位列全球前二強(qiáng)。除了傳染病的應(yīng)用場(chǎng)景之外，利用mNGS還可以對(duì)菌群進(jìn)行菌株鑒定分型、耐藥基因與毒力基因的檢測(cè)，適用于抗傳染院內(nèi)傳染管理的評(píng)估。在越來越多的證據(jù)表明微生物對(duì)人體免疫系統(tǒng)能夠產(chǎn)生影響，以及微生物菌群會(huì)參與到神經(jīng)退行性疾病、糖尿病等疾病的發(fā)生和發(fā)展當(dāng)中，微生物療法獲得了越來越多的關(guān)注，而mNGS未來也可以為人們深入分析人體菌群微生態(tài)、研究微生物療法提供一種可靠的技術(shù)手段。全國開設(shè)病毒宏基因組測(cè)序的公司不超過3家，只有探普生物是專門為病毒研究者服務(wù)的。腸道微生物測(cè)序上哪找</p><p style="text-indent:25px">宏基因組測(cè)序是在未知病原檢測(cè)中發(fā)揮了難以替代的作用。上?？谇晃⑸锒鄻有苑治鲈\斷</p><p style="text-indent:25px">優(yōu)化臨床制備病毒宏基因組測(cè)序樣本的方法：①介紹高通量病毒宏基因組測(cè)序的樣本制備步驟，對(duì)臨床樣本的總核酸進(jìn)行隨機(jī)擴(kuò)增；②檢測(cè)了從血漿樣本中富集/擴(kuò)增DNA及RNA病毒的不同方法，一種包括過濾、核酸酶消化、在不同反應(yīng)中隨機(jī)擴(kuò)增DNA及RNA的步驟是較好的；③隨后在包含了不同病毒科的樣本中驗(yàn)證此方法，可高讀數(shù)地檢測(cè)到大多數(shù)病毒序列，且優(yōu)于現(xiàn)行的其它樣本制備方法；④該方法不僅適用于血漿樣本，還可用于尿液、咽喉拭子等臨床樣本。上?？谇晃⑸锒鄻有苑治鲈\斷</p><p style="text-indent:25px">上海探普生物科技有限公司總部位于放鶴路1088號(hào)6號(hào)樓307，是一家從事生物科技專業(yè)領(lǐng)域內(nèi)技術(shù)開發(fā)、技術(shù)轉(zhuǎn)讓、技術(shù)咨詢、技術(shù)服務(wù)，化工原料及產(chǎn)品（除危險(xiǎn)化學(xué)品、監(jiān)控化學(xué)品、煙花爆竹、民用物品、易制毒化學(xué)品），實(shí)驗(yàn)室設(shè)備，計(jì)算機(jī)、軟件及輔助設(shè)備，電子產(chǎn)品銷售，計(jì)算機(jī)軟件開發(fā)及維護(hù)，計(jì)算機(jī)信息系統(tǒng)集成服務(wù)等。的公司。上海探普生物擁有一支經(jīng)驗(yàn)豐富、技術(shù)創(chuàng)新的專業(yè)研發(fā)團(tuán)隊(duì)，以高度的專注和執(zhí)著為客戶提供病毒測(cè)序，病毒全基因組測(cè)序，病毒宏基因組測(cè)序，未知病原鑒定。上海探普生物致力于把技術(shù)上的創(chuàng)新展現(xiàn)成對(duì)用戶產(chǎn)品上的貼心，為用戶帶來良好體驗(yàn)。上海探普生物創(chuàng)始人喻利，始終關(guān)注客戶，創(chuàng)新科技，竭誠為客戶提供良好的服務(wù)。</p></p><br /><p>文章來源地址: 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