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class="content"><p><span>需求數(shù)量：</span>0</p><p><span>價(jià)格要求：</span>面議</p><p><span>所在地：</span>上海市</p><p><span>包裝要求：</span><span style="color: #f30;"></span></p><p><span>產(chǎn)品關(guān)鍵詞：</span>江蘇細(xì)胞永生化構(gòu)建服務(wù)</p><p><span>***更新：</span>2020-06-25 09:22:14</p><p><span id="click" >瀏覽次數(shù)：0次</span></p><a rel="nofollow" class="button">聯(lián)系我們</a></div></div><div id="xr4vse8" class="rightbox"><h3>公司基本資料信息</h3><p style="border:0;"><a rel="nofollow">上海朝瑞生物科技有限公司</a></p><p><span>聯(lián)系人：</span>仲先生</p><p><span>郵箱: </span>scienceladder@163.com</p><p><span>電話(huà): </span>18621867065</p><p><span>傳真: </span>021_</p><p><span>網(wǎng)址: </span></p><p><span>手機(jī): </span>021-54133071</p><p><span>地址: </span>上海市松江區(qū)廣富林路697號(hào)昂立大廈2113室</p><p>[當(dāng)前離線(xiàn)] <a rel="nofollow"> [加為商友] </a><a rel="nofollow"> [發(fā)送信件] </a></p></div></div><div id="m2btdzw" class="page-proshow02"><p class="title">詳細(xì)說(shuō)明</p><div id="jy92ipw" class="box"><p><p> 如何建立穩(wěn)定永生化細(xì)胞株？來(lái)源：北京安必奇生物科技有限公司2019-3-1訪(fǎng)問(wèn)量：512**論(0)研究背景正常組織來(lái)源的細(xì)胞在體外培養(yǎng)條件下可分裂生長(zhǎng)，但經(jīng)過(guò)有限次數(shù)的傳代后，就會(huì)停止增殖，發(fā)生衰老和死亡，這種現(xiàn)象稱(chēng)之為海弗利克極限。有的細(xì)胞自發(fā)或受外界因素的影響，可以從增殖衰老危機(jī)中逃離，從而擁有無(wú)限增殖的能力，該過(guò)程稱(chēng)之為細(xì)胞永生化。然而自發(fā)永生化的幾率非常小，嚙齒類(lèi)動(dòng)物為10-5-10-6，而人類(lèi)細(xì)胞則更為罕見(jiàn)，小于10-12。通過(guò)轉(zhuǎn)染技術(shù)將外源性永生化基因?qū)肽康募?xì)胞或誘導(dǎo)衰老相關(guān)基因突變，可以增加永生化的發(fā)生率，從而建立穩(wěn)定的永生化細(xì)胞株，江蘇細(xì)胞永生化構(gòu)建服務(wù)。研究意義永生化細(xì)胞能夠提供穩(wěn)定均一、性狀一致的細(xì)胞來(lái)源，并且可以降低材料成本，因此，它是體外研究細(xì)胞增殖、分化、凋亡、衰老等的理想模型，加之，永生化細(xì)胞和**細(xì)胞關(guān)系密切，所以永生化細(xì)胞也是研究**發(fā)生機(jī)制的重要模型。另外，由于永生化細(xì)胞具有可以多次傳代的特性，可以利用各種細(xì)胞永生化的方法使那些傳代困難、增殖緩慢，江蘇細(xì)胞永生化構(gòu)建服務(wù)，江蘇細(xì)胞永生化構(gòu)建服務(wù)、容易衰老的細(xì)胞獲得永生，從而為研究人員提供更多的細(xì)胞資源。研究方法目前，人們已建立了多種細(xì)胞永生化的方法，包括：01***基因轉(zhuǎn)染很多******能夠誘導(dǎo)細(xì)胞永生化。</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="江蘇細(xì)胞永生化構(gòu)建服務(wù)" src="http://tyunfile.71360.com/UploadFile/shchaorui/637122256614785156/7989166.png"></div><p> HPV已成功將人的包皮細(xì)胞、角化上皮以及乳腺、胰導(dǎo)管和口腔等的上皮細(xì)胞永生化。HPVvirus的早期表達(dá)蛋白E6和E7在細(xì)胞永生化中起決定性作用。E6和E7蛋白能夠改變細(xì)胞的終末分化，誘導(dǎo)細(xì)胞進(jìn)入S期，使細(xì)胞繞過(guò)正常細(xì)胞的周期檢查點(diǎn)。virus法獲得的永生化細(xì)胞往往發(fā)生細(xì)胞表型改變，而且一般只應(yīng)用于virus 的特定宿主細(xì)胞。由于該法將整個(gè)virus基因組導(dǎo)入了細(xì)胞，因此，很容易使細(xì)胞轉(zhuǎn)化為**細(xì)胞。 </p> EBV能使B淋巴母細(xì)胞永生化形成淋巴母細(xì)胞樣細(xì)胞系，它是通過(guò)潛伏蛋白activate細(xì)胞因子與其受體相互作用的途徑使細(xì)胞永生的。EBV永生化B細(xì)胞的一個(gè)**明顯的特點(diǎn)是端粒酶活性的提高，這可能是導(dǎo)致B細(xì)胞永生的主要原因。目前，EBvirus介導(dǎo)的細(xì)胞永生化應(yīng)用**多的是B淋巴細(xì)胞，其他細(xì)胞中的應(yīng)用很少。<div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="江蘇細(xì)胞永生化構(gòu)建服務(wù)" src="http://tyunfile.71360.com/UploadFile/shchaorui/637122256594023437/7214116.png"></div><p> 有助讓細(xì)胞永生化的突變對(duì)**產(chǎn)生是至關(guān)重要的，但是在一項(xiàng)新的研究中，來(lái)自美國(guó)加州大學(xué)伯克利分校等研究機(jī)構(gòu)的研究人員指出細(xì)胞變成永生化遠(yuǎn)比原來(lái)想象的更為復(fù)雜。相關(guān)研究結(jié)果于2017年8月17日在線(xiàn)發(fā)表在Science期刊上，論文標(biāo)題為“Mutations in the promoter of the telomerase gene TERT contribute to tumorigenesis by a two-step mechanism”。細(xì)胞永生化的關(guān)鍵是一種被稱(chēng)作端粒酶的酶，它讓染色體在經(jīng)常分裂的細(xì)胞中保持健康。這種酶延長(zhǎng)染色體末端的端粒，在每次細(xì)胞分裂期間，這些端粒就會(huì)變短。當(dāng)端粒太短時(shí)，染色體末端彼此間連接在一起，當(dāng)細(xì)胞分裂時(shí)，這會(huì)造成破壞，在大多數(shù)情況下會(huì)殺死細(xì)胞。鑒于端粒隨著細(xì)胞年齡的增加而變短，科學(xué)家們從理論上認(rèn)為，從不會(huì)衰老的*細(xì)胞通過(guò)產(chǎn)生細(xì)胞在正常情形下不會(huì)產(chǎn)生的端粒酶而變得永生化，從而是得這些細(xì)胞長(zhǎng)久性地保持較長(zhǎng)的端粒。經(jīng)估計(jì)，90%的惡性**利用端粒酶實(shí)現(xiàn)永生化，而且提出的多種**療法都著重關(guān)注降低端粒酶在**中的產(chǎn)生。 </p></p><br /><p>文章來(lái)源地址: http://www.cdcfah.com/cp/384944.html</p></div></div></div></div></div><div id="oscoq89" class="page-right twoColRt"><div id="7gx7hjq" class="box01 margin10 clearfix"><h3><a 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