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src="http://tyunfile.71360.com/UploadFile/shchaorui/637122256584423828/8175635.png" class="vcenter" onerror="javascript:this.src='/static/new_net_01/images/nopic.jpg';"></p></div></div><div id="3hc92w9" class="smallimg"><div><p class="pic"><img src="http://tyunfile.71360.com/UploadFile/shchaorui/637122256584423828/8175635.png" class="vcenter" onerror="javascript:this.src='/static/new_net_01/images/nopic.jpg';"></p></div></div></div><div id="zyf4ugi" class="content"><p><span>需求數(shù)量：</span>0</p><p><span>價(jià)格要求：</span>面議</p><p><span>所在地：</span>上海市</p><p><span>包裝要求：</span><span style="color: #f30;"></span></p><p><span>產(chǎn)品關(guān)鍵詞：</span>江蘇HPV法細(xì)胞永生化構(gòu)建服務(wù)</p><p><span>***更新：</span>2020-06-27 07:20:27</p><p><span id="click" >瀏覽次數(shù)：0次</span></p><a rel="nofollow" class="button">聯(lián)系我們</a></div></div><div id="fzbqmoa" class="rightbox"><h3>公司基本資料信息</h3><p style="border:0;"><a rel="nofollow">上海朝瑞生物科技有限公司</a></p><p><span>聯(lián)系人：</span>仲先生</p><p><span>郵箱: </span>scienceladder@163.com</p><p><span>電話: </span>18621867065</p><p><span>傳真: </span>021_</p><p><span>網(wǎng)址: </span></p><p><span>手機(jī): </span>021-54133071</p><p><span>地址: </span>上海市松江區(qū)廣富林路697號昂立大廈2113室</p><p>[當(dāng)前離線] <a rel="nofollow"> [加為商友] </a><a rel="nofollow"> [發(fā)送信件] </a></p></div></div><div id="yik9tqx" class="page-proshow02"><p class="title">詳細(xì)說明</p><div id="ujg9f7d" class="box"><p><p> 有助讓細(xì)胞永生化的突變對**產(chǎn)生是至關(guān)重要的，但是在一項(xiàng)新的研究中，來自美國加州大學(xué)伯克利分校等研究機(jī)構(gòu)的研究人員指出細(xì)胞變成永生化遠(yuǎn)比原來想象的更為復(fù)雜。相關(guān)研究結(jié)果于2017年8月17日在線發(fā)表在Science期刊上，論文標(biāo)題為“MutationsinthepromoterofthetelomerasegeneTERTcontributetotumorigenesisbyatwo-stepmechanism”。細(xì)胞永生化的關(guān)鍵是一種被稱作端粒酶的酶，它讓染色體在經(jīng)常分裂的細(xì)胞中保持健康。這種酶延長染色體末端的端粒，在每次細(xì)胞分裂期間，這些端粒就會變短。當(dāng)端粒太短時(shí)，染色體末端彼此間連接在一起，當(dāng)細(xì)胞分裂時(shí)，這會造成破壞，在大多數(shù)情況下會殺死細(xì)胞。鑒于端粒隨著細(xì)胞年齡的增加而變短，科學(xué)家們從理論上認(rèn)為，從不會衰老的*細(xì)胞通過產(chǎn)生細(xì)胞在正常情形下不會產(chǎn)生的端粒酶而變得永生化，江蘇HPV法細(xì)胞永生化構(gòu)建服務(wù)，從而是得這些細(xì)胞長久性地保持較長的端粒，江蘇HPV法細(xì)胞永生化構(gòu)建服務(wù)。經(jīng)估計(jì)，90%的惡性**利用端粒酶實(shí)現(xiàn)永生化，而且提出的多種**療法都著重關(guān)注降低端粒酶在**中的產(chǎn)生，江蘇HPV法細(xì)胞永生化構(gòu)建服務(wù)。在這項(xiàng)新的研究中，這些研究人員以體外培養(yǎng)的基因組工程細(xì)胞為實(shí)驗(yàn)對象研究了永生化過程，而且當(dāng)皮膚細(xì)胞從痣進(jìn)展為惡性黑色素瘤時(shí)，也追蹤了它們。</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="江蘇HPV法細(xì)胞永生化構(gòu)建服務(wù)" src="http://tyunfile.71360.com/UploadFile/shchaorui/637122256584423828/8175635.png"></div><p> 這并不令人吃驚雖然大多數(shù)**似乎需要端粒酶變得永生化，但已知只有約10％至20％的**在端粒酶基因上游的啟動子中發(fā)生單核苷酸變化。然而，這包括大約70％的黑色素瘤和50％的肝和膀胱*。Hockemeyer說，用來支持這種TERT啟動子突變上調(diào)端粒酶表達(dá)的理論的證據(jù)一直是自相矛盾的：*細(xì)胞往往具有較短端粒的染色體，但具有更高水平的端粒酶，這種高水平應(yīng)當(dāng)會產(chǎn)生更長的端粒。根據(jù)這些新的發(fā)現(xiàn)，端粒在*前細(xì)胞（precancerouscell）中比較短，這是因?yàn)槎肆Ｃ竸偤米阋跃S持而不延長端粒。Hockemeyer說，“我們的論文調(diào)和了關(guān)于攜帶這種突變的**的相互矛盾的信息?！痹摪l(fā)現(xiàn)還解決了另外一個(gè)**近的違反直覺的發(fā)現(xiàn)：具有更短端粒的人更能抵抗黑色素瘤。他說，其中的原因在于如果一種TERT啟動子突變會促進(jìn)*前病灶（痣）向黑色素瘤轉(zhuǎn)化，那么在具有更短端粒的人中，在細(xì)胞上調(diào)表達(dá)端粒酶和讓它們變得永生化之前，這些細(xì)胞將會死掉。該研究還涉及對由人多能性干細(xì)胞分化的細(xì)胞進(jìn)行基因改造，使之?dāng)y帶TERT啟動子突變，隨后追蹤它們變得永生化的進(jìn)展過程。這些結(jié)果與從加州大學(xué)舊金山分校海倫迪勒家族綜合**中心的患者體內(nèi)獲得的人皮膚病灶樣品中觀察到的進(jìn)展過程是相同的。</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="江蘇HPV法細(xì)胞永生化構(gòu)建服務(wù)" src="http://tyunfile.71360.com/UploadFile/shchaorui/637122256597792968/4214172.png"></div><p> *基因法 </p> <p> 一些原*基因，如Myc, c-Jun, c-Ias, vsrc和Mdm2，通過基因轉(zhuǎn)染可介導(dǎo)目的細(xì)胞永生化。c-Myc是**早被發(fā)現(xiàn)的原*基因，有許多與瘤化相關(guān)的功能區(qū)域，其轉(zhuǎn)錄表達(dá)的蛋白通過核膜進(jìn)入細(xì)胞核與端粒酶的啟動子結(jié)合位點(diǎn)特異性結(jié)合，誘導(dǎo)端粒酶mRNA快速表達(dá)，直接ji活端粒酶活性，促進(jìn)細(xì)胞進(jìn)入永生化。 </p> <p> 細(xì)胞永生化過程中，抑*基因如p53, pRb, BRCA1, DPC4等，通過等位基因隱性作用、抑*基因的顯性負(fù)作用等逐漸失去活性，細(xì)胞老化途徑受阻。實(shí)驗(yàn)證明端粒酶的活性與抑*基因表達(dá)產(chǎn)物的下調(diào)有相關(guān)關(guān)系，推測抑*基因的失活協(xié)同端粒酶的ji活共同參與細(xì)胞永生化進(jìn)程。 </p> <p> <br /> </p></p><br /><p>文章來源地址: http://www.cdcfah.com/cp/408229.html</p></div></div></div></div></div><div id="yipz3vp" class="page-right twoColRt"><div id="3bncoqx" class="box01 margin10 clearfix"><h3><a href="http://www.cdcfah.com/cp/">猜你喜歡</a></h3><div id="odfplik" class="recomPic likePro"><a href="http://www.cdcfah.com/cp/814588.html"><div><img 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