上海遺傳毒理學(xué)安全性評價歡迎咨詢上海朝瑞生物科技供應(yīng)-b2b網(wǎng)站_b2b電子商務(wù)平臺【買產(chǎn)品】-上?？谄蚴称酚邢薰?/title><meta name="description" content="黃素咀嚼片作為功能性食品食用的毒理學(xué)安全性。方法:按照我國衛(wèi)生部《食品安全毒理學(xué)評價程序和檢驗方法規(guī)范》進行急性毒性試驗、遺傳毒性試驗(Ames試驗、小鼠骨髓細胞微核試驗、小鼠精子畸形試驗)和30d喂養(yǎng)試驗進行毒理學(xué)研究。結(jié)果:葉黃素咀嚼片"><meta name="keywords" content="上海遺傳毒理學(xué)安全性評價,毒理學(xué)安全性評價"><link rel="canonical" href="http://www.cdcfah.com/"/><meta name="applicable-device" content="pc"><link rel="shortcut icon" href="/static/new_net_01/images/favicon.ico"><link rel="stylesheet" href="/static/new_net_01/css/slick.css" /><link rel="stylesheet" href="/static/new_net_01/css/addnew.css"><link rel="stylesheet" href="/static/new_net_01/css/sidenav.css"><link rel="stylesheet" href="/static/new_net_01/css/style.css" /><link rel="stylesheet" href="/static/new_net_01/css/tab.css"><link rel="stylesheet" href="/static/new_net_01/css/404.css"> <meta name="baidu-site-verification" content="OBVzrC9aaQ" /> <meta http-equiv="Cache-Control" 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#f30;"></span></p><p><span>產(chǎn)品關(guān)鍵詞：</span>上海遺傳毒理學(xué)安全性評價,毒理學(xué)安全性評價</p><p><span>***更新：</span>2020-07-03 09:15:51</p><p><span id="click" >瀏覽次數(shù)：0次</span></p><a rel="nofollow" class="button">聯(lián)系我們</a></div></div><div id="bcjgyx3" class="rightbox"><h3>公司基本資料信息</h3><p style="border:0;"><a rel="nofollow">上海朝瑞生物科技有限公司</a></p><p><span>聯(lián)系人：</span>仲先生</p><p><span>郵箱: </span>scienceladder@163.com</p><p><span>電話: </span>18621867065</p><p><span>傳真: </span>021_</p><p><span>網(wǎng)址: </span></p><p><span>手機: </span>021-54133071</p><p><span>地址: </span>上海市松江區(qū)廣富林路697號昂立大廈2113室</p><p>[當前離線] <a rel="nofollow"> [加為商友] </a><a rel="nofollow"> [發(fā)送信件] </a></p></div></div><div id="lur39ml" class="page-proshow02"><p class="title">詳細說明</p><div id="fzfht23" class="box"><p><p style="text-indent:25px">黃素咀嚼片作為功能性食品食用的毒理學(xué)安全性。方法:按照我國衛(wèi)生部《食品安全毒理學(xué)評價程序和檢驗方法規(guī)范》進行急性毒性試驗、遺傳毒性試驗(Ames試驗、小鼠骨髓細胞微核試驗、小鼠精子畸形試驗)和30 d喂養(yǎng)試驗進行毒理學(xué)研究。結(jié)果:葉黃素咀嚼片對兩種性別的ICR小鼠急性經(jīng)口比較大耐受劑量>20.0g/kgbw,按照急性毒性分級標準規(guī)定,該受試物屬無毒級;遺傳毒性試驗(Ames試驗、骨髓細胞微核試驗、小鼠精子畸形試驗)均為陰性;30d喂養(yǎng)試驗表明，上海遺傳毒理學(xué)安全性評價,該受試物在0，上海遺傳毒理學(xué)安全性評價.19、0.38、0，上海遺傳毒理學(xué)安全性評價.75g/kgbw(分別相當于推薦人群日攝入量的25、50、100倍)劑量時,對SD大鼠的臨床檢查、血液學(xué)、血生化學(xué)和臟器重量和系數(shù)以及病理組織形態(tài)等指標均無明顯不良影響。結(jié)論:葉黃素咀嚼片具有較好的食用安全性。上海遺傳毒理學(xué)安全性評價</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="上海遺傳毒理學(xué)安全性評價,毒理學(xué)安全性評價" src="http://tyunfile.71360.com/UploadFile/shchaorui/637129699848623047/8974668.png"></div><p style="text-indent:25px">銀杏葉提取物膠囊的食用安全性進行毒理學(xué)實驗評價。方法采用小鼠急性經(jīng)口毒性試驗、遺傳毒性試驗（Ames試驗、小鼠骨髓微核試驗、小鼠精子畸形試驗）和30d喂養(yǎng)試驗進行檢測評價。結(jié)果小鼠急性經(jīng)口毒性MTD〉20g／kg·bw，三項遺傳毒性試驗結(jié)果均為陰性。30d喂養(yǎng)試驗未顯示明顯毒性。結(jié)論銀杏葉提取物膠囊急性毒性分級屬無毒級，無遺傳毒性，按推薦量食用是安全的。Objective To assess the edible safety oI Propolis capsule. Nletllotls [l~e toxicity was Oetermmed Dy a- cute toxicity test and thirty day feeding tests. The mutations of Propolis capsule was tested using micronucleus test in bonemarrow cell,sperm shape abnormality test and Ames test. The teratogenicity was also assessed. Results The acute oral MTD in mice was over 20.0 g/kg · bw. The results of micronucles test in bone marrow ceil, sperm shape abnormali- ty, Ames test were negative, without significant differences, i-Conclusion]Ginkgo biloba extract capsule belongs to the actu- al innocuous level no-genetic toxicity,being used for food according to recommending amounts is sMe.上海遺傳毒理學(xué)安全性評價</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="上海遺傳毒理學(xué)安全性評價,毒理學(xué)安全性評價" src="http://tyunfile.71360.com/UploadFile/shchaorui/637129699841435547/3737546.png"></div><p> **項試驗可用同一批動物進行。關(guān)于喂養(yǎng)致畸和傳統(tǒng)致畸試驗的選擇，可根據(jù)受試物的性質(zhì)而定。當對任何一種致畸實驗的結(jié)果已能作出明確評價時，不要求作另一種致畸試驗。但在結(jié)果不足以作出評價，或者有關(guān)**共同評議后認為需要時，再進行另一種致畸實驗。3.結(jié)果判定：如以上試驗中任何一項的**敏感的比較大無作用劑量（以mg/kg體重計）Ⅰ小于或等于人的可能攝入量的100倍者，表示毒性較強，應(yīng)予以放棄；Ⅱ大于100倍而小于300倍者，可進行慢性毒性實驗；Ⅲ大于300倍者，則不必進行慢性試驗，可進行評價安全毒理學(xué)評價（4）第四階段慢性毒性試驗?zāi)康模韩@得經(jīng)長期接觸受試物后出現(xiàn)的毒性作用以及致*作用資料，從而確定比較大未觀察到有害作用的劑量，為受試物能否應(yīng)用于食品的**終評價提供依據(jù)。試驗項目：將兩年慢性毒性試驗和致*試驗結(jié)合在一個動物試驗中進行。用兩種性別的大鼠和（或）小鼠結(jié)果判定：如慢性毒性試驗所得的比較大無作用劑量。以mg/kg體重計）Ⅰ小于或等于人的可能攝入量的50倍者，表示毒性較強，應(yīng)予以放棄；Ⅱ大于50倍而小于100倍者需由有關(guān)**共同評議；Ⅲ大于或等于100倍者，則可考慮允許使用于食品，并制定日許量（ADI）。</p><p> 通過體外試驗、動物試驗和人群觀察，發(fā)現(xiàn)和闡明被評價物質(zhì)（食品或與食品有關(guān)的產(chǎn)品）的毒性和潛在的危害，以便對人類使用這種食品的安全性作出評價，并為制定預(yù)防措施和衛(wèi)生標準提供理論依據(jù)。毒理學(xué)實驗四個階段： </p> <p> ***階段：急性毒性試驗：它是一次性投較大劑量后觀察動物的變化，觀察期大約為1周，從而判定動物的致死量（LD）和半致死量（LD50）。半致死量是指實驗動物死亡一半的投藥量。如果投藥量大于5000mg/kg，無死亡，可認為該品毒性較低，無需做致死量精確測定。 </p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="上海遺傳毒理學(xué)安全性評價,毒理學(xué)安全性評價" src="http://tyunfile.71360.com/UploadFile/shchaorui/637129699842666016/4400715.png"></div><p> 按照我國衛(wèi)生部《食品安全毒理學(xué)評價程序和檢驗方法規(guī)范》，采用急性毒性試驗、Ames試驗、小鼠骨髓嗜多染紅細胞微核試驗和小鼠精子畸形試驗對植物甾醇作為食品添加劑和保健食品原料的食用安全性進行評價。結(jié)果顯示：大、小鼠急性經(jīng)口LD50大于5 000 mg/kg，Ames試驗、小鼠骨髓嗜多染紅細胞微核試驗和小鼠精子畸形試驗結(jié)果均為陰性。由此得出植物甾醇屬于實際***物，可以作為一種食品添加劑和保健食品原料進行開發(fā)、利用。 </p> <p> 關(guān)鍵詞：植物甾醇；安全性；毒理試驗；Ames試驗；微核試驗；精子畸形試驗上海遺傳毒理學(xué)安全性評價</p><p style="text-indent:25px">上海遺傳毒理學(xué)安全性評價</p><p> 擴展資料：一、食品安全性毒理學(xué)評價實驗項目；***階段：急性毒性試驗，試驗項目：1.用霍恩氏法、機率單位法或寇氏法，測定經(jīng)口半數(shù)致死量（LD50）。如劑量達10克/公斤體重仍不引起動物死亡，則不必測定半數(shù)致死量。2.必要時進行七天喂養(yǎng)試驗。以上兩個項目均分別用兩種性別的小鼠或大鼠。第二階段：蓄積毒性和致突變試驗，試驗項目：1.蓄積系數(shù)法。用兩種性別的大鼠或小鼠，各20只。2.二十天試驗法。用兩種性別的大鼠或小鼠，每個劑量組雌雄各10只。以上兩種方法任選一種。第三階段：亞慢性毒性（包括繁殖、致畸）試驗和代謝試驗，試驗項目：。2.喂養(yǎng)繁殖試驗。3.喂養(yǎng)致畸試驗。4.傳統(tǒng)致畸試驗。第四階段：慢性毒性（包括致*）試驗，試驗項目：可將兩年慢性毒性試驗和致*試驗結(jié)合在一個動物試驗中進行。用兩種性別的大鼠或小鼠。二：食品安全性毒理學(xué)評價實驗要求：1、凡屬我國創(chuàng)制的新化學(xué)物質(zhì)，一般要求進行四個階段的試驗。特別是對其中化學(xué)結(jié)構(gòu)提示有慢性毒性或致*作用可能者，產(chǎn)量大、使用面積廣、攝入機會多者，必需進行全部四個階段的試驗。2、凡屬與已知物質(zhì)（指經(jīng)過安全性評價并允許使用者）的化學(xué)結(jié)構(gòu)基本相同的衍生物，則可根據(jù)***、二、三階段試驗的結(jié)果。上海遺傳毒理學(xué)安全性評價</p><p style="text-indent:25px">上海朝瑞生物科技有限公司一直專注于1.發(fā)布科研技術(shù) 2.發(fā)布應(yīng)用技術(shù) 3.發(fā)布專業(yè)專長 4.發(fā)布科研成果 5.發(fā)布我的需求 6.發(fā)布篩選檢驗檢測服務(wù) 7.發(fā)布協(xié)同代研發(fā)服務(wù) 8.發(fā)布升級改造產(chǎn)品服務(wù) 9.發(fā)布實驗室及儀器設(shè)備共享 10.發(fā)布培訓(xùn)基地共享 11.發(fā)布工廠代加工及共享車間 12.發(fā)布科研/項目團隊招聘13.發(fā)布研究生婚戀 14.發(fā)布項目整包服務(wù) 15.發(fā)布資源交換業(yè)務(wù)，是一家化工的企業(yè)，擁有自己**的技術(shù)體系。公司目前擁有高技術(shù)人才5~10人人，以不斷增強企業(yè)核心競爭力，加快企業(yè)技術(shù)創(chuàng)新，實現(xiàn)穩(wěn)健生產(chǎn)經(jīng)營。上海朝瑞生物科技有限公司主營業(yè)務(wù)涵蓋[ "科研技術(shù)服務(wù)", "應(yīng)用技術(shù)服務(wù)", "科研成果轉(zhuǎn)化", "科學(xué)產(chǎn)品銷售" ]，堅持“質(zhì)量***、質(zhì)量服務(wù)、顧客滿意”的質(zhì)量方針，贏得廣大客戶的支持和信賴。公司憑著雄厚的技術(shù)力量、飽滿的工作態(tài)度、扎實的工作作風、良好的職業(yè)道德，樹立了優(yōu)良的[ "科研技術(shù)服務(wù)", "應(yīng)用技術(shù)服務(wù)", "科研成果轉(zhuǎn)化", "科學(xué)產(chǎn)品銷售" ]形象，贏得了社會各界的信任和認可。</p></p><br /><p>文章來源地址: http://www.cdcfah.com/cp/478833.html</p></div></div></div></div></div><div id="ehe8r4s" class="page-right twoColRt"><div id="rq8azyv" class="box01 margin10 clearfix"><h3><a href="http://www.cdcfah.com/cp/">猜你喜歡</a></h3><div id="qaxub2y" class="recomPic likePro"><a href="http://www.cdcfah.com/cp/814588.html"><div><img src="http://tyunfile.71360.com/UpLoadFile/2019/11/1/14/637082168864691056_lgpj_5374157.jpg" alt="福建ZF配件哪家強信息推薦自業(yè)物資供應(yīng)" class="vcenter" 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