北京特異Claudin18.2蛋白哪家好 **** 上海朝瑞生物科技供應(yīng)-b2b網(wǎng)站_b2b電子商務(wù)平臺(tái)【買產(chǎn)品】-上?？谄蚴称酚邢薰?/title><meta name="description" content="Claudin是細(xì)胞粘合蛋白之一，有20幾個(gè)家族成員，不同組織、不同亞型的Claudin除粘合細(xì)胞外還有其它功能。Claudin18.2*在胃上皮細(xì)胞短暫表達(dá)，其它正常組織幾乎沒有表達(dá)。但是很多組織*變后Claudin18.2表達(dá)會(huì)異常升高"><meta name="keywords" content="北京特異Claudin18.2蛋白哪家好"><link rel="canonical" href="http://www.cdcfah.com/"/><meta name="applicable-device" content="pc"><link rel="shortcut icon" href="/static/new_net_01/images/favicon.ico"><link rel="stylesheet" href="/static/new_net_01/css/slick.css" /><link rel="stylesheet" href="/static/new_net_01/css/addnew.css"><link rel="stylesheet" href="/static/new_net_01/css/sidenav.css"><link rel="stylesheet" href="/static/new_net_01/css/style.css" /><link rel="stylesheet" href="/static/new_net_01/css/tab.css"><link rel="stylesheet" href="/static/new_net_01/css/404.css"> <meta name="baidu-site-verification" content="OBVzrC9aaQ" /> <meta http-equiv="Cache-Control" 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id="o3iul82" class="page-proshow clearfix"><p class="current"> 當(dāng)前位置:<a href="http://www.cdcfah.com/">首頁?<a href="http://www.cdcfah.com/cp/">產(chǎn)品供應(yīng)</a>?<a href="http://www.cdcfah.com/cp/second-_nongye/">農(nóng)業(yè)</a>?<a href="http://www.cdcfah.com/cp/third-nongye_nlmyxmhz/">農(nóng)林牧漁項(xiàng)目合作</a>?北京特異Claudin18.2蛋白哪家好 **** 上海朝瑞生物科技供應(yīng)</p><div id="8d7i8zo" class="leftbox clearfix"><h1>北京特異Claudin18.2蛋白哪家好 **** 上海朝瑞生物科技供應(yīng)</h1><div id="o2yld39" class="proBig"><div id="wpzyfrt" class="bigimg"><div><p class="pic"><img src="http://tyunfile.71360.com/UploadFile/shchaorui/637123969947460937/5782493.png" class="vcenter" onerror="javascript:this.src='/static/new_net_01/images/nopic.jpg';"></p></div></div><div id="o8dfmel" class="smallimg"><div><p class="pic"><img src="http://tyunfile.71360.com/UploadFile/shchaorui/637123969947460937/5782493.png" class="vcenter" onerror="javascript:this.src='/static/new_net_01/images/nopic.jpg';"></p></div></div></div><div id="jd8jb2d" class="content"><p><span>需求數(shù)量：</span>0</p><p><span>價(jià)格要求：</span>面議</p><p><span>所在地：</span>上海市</p><p><span>包裝要求：</span><span style="color: #f30;"></span></p><p><span>產(chǎn)品關(guān)鍵詞：</span>北京特異Claudin18.2蛋白哪家好</p><p><span>***更新：</span>2020-05-27 01:30:22</p><p><span id="click" >瀏覽次數(shù)：0次</span></p><a rel="nofollow" class="button">聯(lián)系我們</a></div></div><div id="aztkmo8" class="rightbox"><h3>公司基本資料信息</h3><p style="border:0;"><a rel="nofollow">上海朝瑞生物科技有限公司</a></p><p><span>聯(lián)系人：</span>仲先生</p><p><span>郵箱: </span>scienceladder@163.com</p><p><span>電話: </span>18621867065</p><p><span>傳真: </span>021_</p><p><span>網(wǎng)址: </span></p><p><span>手機(jī): </span>021-54133071</p><p><span>地址: </span>上海市松江區(qū)廣富林路697號(hào)昂立大廈2113室</p><p>[當(dāng)前離線] <a rel="nofollow"> [加為商友] </a><a rel="nofollow"> [發(fā)送信件] </a></p></div></div><div id="f77y7aq" class="page-proshow02"><p class="title">詳細(xì)說明</p><div id="nr7x7of" class="box"><p><p style="text-indent:25px">Claudin是細(xì)胞粘合蛋白之一，有20幾個(gè)家族成員，不同組織、不同亞型的Claudin除粘合細(xì)胞外還有其它功能。Claudin18.2*在胃上皮細(xì)胞短暫表達(dá)，其它正常組織幾乎沒有表達(dá)。但是很多組織*變后Claudin18.2表達(dá)會(huì)異常升高，目前這個(gè)蛋白在**發(fā)生、轉(zhuǎn)移中的作用尚不清楚，北京特異Claudin18.2蛋白哪家好，北京特異Claudin18.2蛋白哪家好，似乎與細(xì)胞粘合關(guān)系不大。簡單從細(xì)胞粘合機(jī)理看阻斷Claudin似乎會(huì)打碎細(xì)胞聯(lián)合、加速**轉(zhuǎn)移，北京特異Claudin18.2蛋白哪家好，也確實(shí)有研究顯示阻斷某些Claudin會(huì)加速**轉(zhuǎn)移。但是因?yàn)镃laudin18.2只在**細(xì)胞表達(dá)，所以可以比較安全地用抗體誘導(dǎo)細(xì)胞殺傷。這和CD19、CD20抗體的思路類似，只是實(shí)體瘤特異的表面蛋白很少。這個(gè)靶點(diǎn)很多細(xì)節(jié)還需進(jìn)一步研究。</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="北京特異Claudin18.2蛋白哪家好" src="http://tyunfile.71360.com/UploadFile/shchaorui/637123969947460937/5782493.png"></div><p> 緊密連接被破壞，claudin蛋白質(zhì)失去了其主要作用。IMAB362是較早靶向claudin。當(dāng)該抗體附著在**細(xì)胞的，被涂在抗體上的各種類型的細(xì)胞和可溶性免疫效應(yīng)物通過殺死**細(xì)胞產(chǎn)生應(yīng)答。這些過程抗體-依賴性細(xì)胞-介導(dǎo)的細(xì)胞毒性（ADCC）和補(bǔ)體-依賴性細(xì)胞毒性（CDC）。關(guān)于這項(xiàng)研究胃*是世界上第五種最常見的**，2012年有接近100萬新增胃*病例。晚期或復(fù)發(fā)性胃*的標(biāo)準(zhǔn)*****是化療。曲妥珠單抗加入化療為HER2-陽性**患者提供一定的生存獲益，但是所有胃*中只有15%為HER2-陽性。這項(xiàng)研究納入161例晚期或復(fù)發(fā)性胃*或胃食管交界*，并且他們**中claudin（來自**活檢樣本的分析評(píng)估聯(lián)合經(jīng)驗(yàn)證的CE-標(biāo)志的診斷分析）。這些患者之前沒有接受過轉(zhuǎn)移性*的***，接受HER2曲妥珠單抗***的患者不符合入組要求?；颊弑浑S機(jī)分配接受標(biāo)準(zhǔn)化療（表柔比星，奧沙利鉑，和卡培他濱）或者化療聯(lián)合IMAB362。關(guān)鍵發(fā)現(xiàn)與單純化療相比較，IMAB362將平均疾病進(jìn)展時(shí)間從，中位總生存期從。在比較高claudin，化療+IMAB362的中位總生存期是，單純化療的中位總生存期是9個(gè)月。根據(jù)作者介紹，這種***耐受性良好。嘔吐（對(duì)照組：vsIMAB362組：）和低血細(xì)胞計(jì)數(shù)或者中性粒細(xì)胞減少。</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="北京特異Claudin18.2蛋白哪家好" src="http://tyunfile.71360.com/UploadFile/shchaorui/637123969973388672/6942875.png"></div><p> 現(xiàn)實(shí)生活中，8胃*、胰腺*、食道*以及轉(zhuǎn)移和未轉(zhuǎn)移卵巢*免疫zhilao中存在著手術(shù)切除復(fù)發(fā)率高、化療和放療毒副作用強(qiáng)以及單抗zhilao費(fèi)用高的問題，迫切需要新的技術(shù)產(chǎn)生，而通過對(duì)claudins在胃*中異常分布和表達(dá)的研究，人們能更好得理解胃*的發(fā)展機(jī)制，從而有利于胃*的診斷和zhilao。Claudins在胃*前病變、胃*各期和各型中的表達(dá)的研究是近年熱點(diǎn)，其中claudin-4、claudin-7和ctaudin-18研究較多。Claudin-4定位在人類染色體7ql1。Lee等用免疫組化法研究發(fā)現(xiàn)E-cadherin和claudin-4在69n/。的胃*中均表達(dá)減少，且更常見于彌散型胃*和分化低的胃*，認(rèn)為兩種蛋白作用類似，可能與胃腺體結(jié)構(gòu)的破壞和腺體細(xì)胞的分化喪失有關(guān)。Resnick等研究遠(yuǎn)端胃*患者通過COX多變量分析，發(fā)現(xiàn)**度claudin-4的表達(dá)與胃*患者生存期明顯下降有關(guān)。此外，Cunningham等。通過免疫組化方法發(fā)現(xiàn)claudin-4在36例腸化和14例不典型增生患者中均完全有表達(dá)，在98%胃*原位組織和全部的轉(zhuǎn)移*組織中也有表達(dá)，而*有15%的正常胃黏膜組織表達(dá)claudin-4，說明claudin-4在胃*早期的致*過程中也起了重要作用。 </p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="北京特異Claudin18.2蛋白哪家好" src="http://tyunfile.71360.com/UploadFile/shchaorui/637123969952373047/7079061.png"></div></p><br /><p>文章來源地址: 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