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href="http://www.cdcfah.com/cp/second-_nongye/">農(nóng)業(yè)</a>?<a href="http://www.cdcfah.com/cp/third-nongye_nlmyxmhz/">農(nóng)林牧漁項目合作</a>?江蘇局部毒理學(xué)安全性評價實驗服務(wù) 來電咨詢上海朝瑞生物科技供應(yīng)</p><div id="mgylsjg" class="leftbox clearfix"><h1>江蘇局部毒理學(xué)安全性評價實驗服務(wù) 來電咨詢上海朝瑞生物科技供應(yīng)</h1><div id="bvhe7a4" class="proBig"><div id="cgdfxeb" class="bigimg"><div><p class="pic"><img src="http://tyunfile.71360.com/UploadFile/shchaorui/637129699852187500/2173424.png" class="vcenter" onerror="javascript:this.src='/static/new_net_01/images/nopic.jpg';"></p></div></div><div id="la3gi7m" class="smallimg"><div><p class="pic"><img src="http://tyunfile.71360.com/UploadFile/shchaorui/637129699852187500/2173424.png" class="vcenter" onerror="javascript:this.src='/static/new_net_01/images/nopic.jpg';"></p></div></div></div><div id="f33ovc2" class="content"><p><span>需求數(shù)量：</span>0</p><p><span>價格要求：</span>面議</p><p><span>所在地：</span>上海市</p><p><span>包裝要求：</span><span style="color: #f30;"></span></p><p><span>產(chǎn)品關(guān)鍵詞：</span>江蘇局部毒理學(xué)安全性評價實驗服務(wù),毒理學(xué)安全性評價</p><p><span>***更新：</span>2020-07-07 00:29:43</p><p><span id="click" >瀏覽次數(shù)：0次</span></p><a rel="nofollow" class="button">聯(lián)系我們</a></div></div><div id="7j8ldpr" class="rightbox"><h3>公司基本資料信息</h3><p style="border:0;"><a rel="nofollow">上海朝瑞生物科技有限公司</a></p><p><span>聯(lián)系人：</span>仲先生</p><p><span>郵箱: </span>scienceladder@163.com</p><p><span>電話: </span>18621867065</p><p><span>傳真: </span>021_</p><p><span>網(wǎng)址: </span></p><p><span>手機: </span>021-54133071</p><p><span>地址: </span>上海市松江區(qū)廣富林路697號昂立大廈2113室</p><p>[當(dāng)前離線] <a rel="nofollow"> [加為商友] </a><a rel="nofollow"> [發(fā)送信件] </a></p></div></div><div id="pogyvxe" class="page-proshow02"><p class="title">詳細(xì)說明</p><div id="hgik7gf" class="box"><p><p> **項試驗可用同一批動物進(jìn)行。關(guān)于喂養(yǎng)致畸和傳統(tǒng)致畸試驗的選擇，可根據(jù)受試物的性質(zhì)而定。當(dāng)對任何一種致畸實驗的結(jié)果已能作出明確評價時，不要求作另一種致畸試驗。但在結(jié)果不足以作出評價，或者有關(guān)**共同評議后認(rèn)為需要時，江蘇局部毒理學(xué)安全性評價實驗服務(wù)，再進(jìn)行另一種致畸實驗。3.結(jié)果判定：如以上試驗中任何一項的**敏感的比較大無作用劑量（以mg/kg體重計）Ⅰ小于或等于人的可能攝入量的100倍者，表示毒性較強，應(yīng)予以放棄；Ⅱ大于100倍而小于300倍者，可進(jìn)行慢性毒性實驗；Ⅲ大于300倍者，江蘇局部毒理學(xué)安全性評價實驗服務(wù)，則不必進(jìn)行慢性試驗，可進(jìn)行評價安全毒理學(xué)評價（4）第四階段慢性毒性試驗?zāi)康模韩@得經(jīng)長期接觸受試物后出現(xiàn)的毒性作用以及致*作用資料，從而確定比較大未觀察到有害作用的劑量，為受試物能否應(yīng)用于食品的**終評價提供依據(jù)。試驗項目：將兩年慢性毒性試驗和致*試驗結(jié)合在一個動物試驗中進(jìn)行。用兩種性別的大鼠和（或）小鼠結(jié)果判定：如慢性毒性試驗所得的比較大無作用劑量，江蘇局部毒理學(xué)安全性評價實驗服務(wù)。以mg/kg體重計）Ⅰ小于或等于人的可能攝入量的50倍者，表示毒性較強，應(yīng)予以放棄；Ⅱ大于50倍而小于100倍者需由有關(guān)**共同評議；Ⅲ大于或等于100倍者，則可考慮允許使用于食品，并制定日許量（ADI）。江蘇局部毒理學(xué)安全性評價實驗服務(wù)</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="江蘇局部毒理學(xué)安全性評價實驗服務(wù),毒理學(xué)安全性評價" src="http://tyunfile.71360.com/UploadFile/shchaorui/637129699852187500/2173424.png"></div><p> 1）收集化學(xué)物質(zhì)有關(guān)的基本資料；（2）了解化學(xué)物質(zhì)的使用情況；（3）選用人類實際接觸和應(yīng)用的產(chǎn)品形式進(jìn)行實驗；（4）選擇實驗動物的要求。安全毒理學(xué)評價選用原則編輯（1）凡屬我國創(chuàng)新的受試物一般要求進(jìn)行四個階段的試驗，特別是對其中化學(xué)結(jié)構(gòu)提示有慢性毒性、遺傳毒性或致*性可能者或產(chǎn)量大、使用范圍廣、攝入機會者多，必須進(jìn)行全部四個階段的毒性試驗。（2）凡屬與已知物質(zhì)（指經(jīng)過安全性評價并允許使用者）的化學(xué)結(jié)構(gòu)基本相同的衍生物或類似物，則根據(jù)一、二、三階段毒性試驗結(jié)果判斷是否需要進(jìn)行第四階段試驗。（3）凡屬已知的化學(xué)物質(zhì)，世界衛(wèi)生組織對其已公布每人每日允許攝入量（ADI）的，同時申請單位又有資料證明我國產(chǎn)品的質(zhì)量規(guī)格與國外產(chǎn)品一致，則可先進(jìn)行***、二階段試驗。如果產(chǎn)品質(zhì)量或者試驗結(jié)果與國外資料一致，一般不要求進(jìn)一步的毒性試驗，否則應(yīng)進(jìn)行第三階段試驗。（4）農(nóng)藥、食品添加劑、食品新資源和新資源食品、輻照食品、食品工具以及設(shè)備用清洗消毒劑的安全性毒理學(xué)評價試驗選擇應(yīng)分別符合規(guī)定要求。安全毒理學(xué)評價主要內(nèi)容和程序編輯毒理學(xué)試驗分為4個階段：安全毒理學(xué)評價（1）***階段急性毒性試驗?zāi)康模罕驹囼灉y定LD50。江蘇局部毒理學(xué)安全性評價實驗服務(wù)</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="江蘇局部毒理學(xué)安全性評價實驗服務(wù),毒理學(xué)安全性評價" src="http://tyunfile.71360.com/UploadFile/shchaorui/637129699839287110/5826880.png"></div><p> 過體外試驗、動物試驗和人群觀察，發(fā)現(xiàn)和闡明被評價物質(zhì)（食品或與食品有關(guān)的產(chǎn)品）的毒性和潛在的危害，以便對人類使用這種食品的安全性作出評價，并為制定預(yù)防措施和衛(wèi)生標(biāo)準(zhǔn)提供理論依據(jù)。毒理學(xué)實驗四個階段： </p> <p> 第四階段：慢性毒性實驗：考查少量該品長期對機體的影響，確定比較大無作用量（MNL），一般以壽命較短敏感的動物的一生為一個試驗階段，如用大白鼠試驗2年小白鼠試驗1.5年。目的：獲得經(jīng)長期接觸受試物后出現(xiàn)的毒性作用以及致*作用資料，從而確定比較大未觀察到有害作用的劑量，為受試物能否應(yīng)用于食品的**終評價提供依據(jù)。試驗項目：將兩年慢性毒性試驗和致*試驗結(jié)合在一個動物試驗中進(jìn)行。用兩種性別的大鼠和（或）小鼠結(jié)果判定：如慢性毒性試驗所得的比較大無作用劑量（以mg/kg體重計） </p><p> 產(chǎn)品類別檢測項目食品（保健食品）食品（保健食品）急性經(jīng)口毒性試驗(限量法)食品（保健食品）細(xì)菌回復(fù)突變試驗食品（保健食品）哺乳動物紅細(xì)胞微核試驗食品（保健食品）精母細(xì)胞染色體畸變試驗食品（保健食品）28天經(jīng)口毒性試驗食品90天經(jīng)口毒性試驗食品致畸試驗化妝品化妝品皮膚刺激性/腐蝕性試驗化妝品急性眼刺激性/腐蝕性試驗化妝品皮膚***反應(yīng)試驗皮膚光毒性試驗化妝品急性經(jīng)皮毒性試驗(限量法)化妝品鼠傷寒沙門氏菌／回復(fù)突變試驗化妝品體內(nèi)哺乳動物細(xì)胞微核試驗消毒產(chǎn)品消毒產(chǎn)品多次完整皮膚刺激試驗消毒產(chǎn)品急性經(jīng)口毒性試驗(限量法)消毒產(chǎn)品急性眼刺激試驗消毒產(chǎn)品一次破損皮膚刺激試驗消毒產(chǎn)品一次完整皮膚刺激試驗消毒產(chǎn)品睪丸生殖細(xì)胞染色體畸變試驗消毒用品微核試驗消毒產(chǎn)品急性吸入毒性試驗一次使用衛(wèi)生用品一次使用衛(wèi)生用品多次皮膚刺激試驗一次性使用衛(wèi)生用品皮膚***反應(yīng)試驗一次性使用衛(wèi)生用品陰道黏膜刺激試驗危險廢物危險廢物急性經(jīng)口毒性試驗危險廢物急性經(jīng)皮毒性試驗危險廢物急性吸入毒性試驗化學(xué)品化學(xué)品急性經(jīng)口毒性試驗化學(xué)品急性皮膚刺激性/腐蝕性試驗化學(xué)品急性吸入毒性試驗化學(xué)品急性經(jīng)皮毒性試驗化學(xué)品皮膚致敏試驗化學(xué)品急性眼刺激性/腐蝕性試。</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="江蘇局部毒理學(xué)安全性評價實驗服務(wù),毒理學(xué)安全性評價" src="http://tyunfile.71360.com/UploadFile/shchaorui/637129699841240235/9964408.png"></div><p> 經(jīng)口半數(shù)致死量），了解受試物的毒性強度、性質(zhì)和可能的靶***，為進(jìn)一步進(jìn)行毒性試驗的劑量和毒性觀察指標(biāo)的選擇提供依據(jù)，并根據(jù)LD50進(jìn)行毒性分級。試驗項目：①霍恩氏法、機率單位法或寇氏法測定經(jīng)口半數(shù)致死量（LD50）；②7天喂養(yǎng)試驗。以上兩個項目分別用兩種性別的小鼠和（或）大鼠進(jìn)行結(jié)果判定：①LD50或7天喂養(yǎng)試驗的**小有作用劑量小于人的可能攝入量的10倍者，則放棄不再繼續(xù)試驗；②大于10倍者，可進(jìn)入下一階段試驗。為慎重起見，凡LD50在10倍左右時，應(yīng)進(jìn)行重復(fù)試驗，或用另一種方法進(jìn)行驗證。[2]安全毒理學(xué)評價（2）第二階段遺傳毒性試驗考慮原核細(xì)胞與真核細(xì)胞、體內(nèi)試驗和體外試驗相結(jié)合的原則選擇試驗組合，對受試物的遺傳毒性以及是否具有潛在致*作用進(jìn)行篩選。食品毒理學(xué)中的傳統(tǒng)致畸試驗是限定于受孕動物的觀察，了解受試物是否具有致畸作用。在急性毒性試驗的基礎(chǔ)上，通過30天喂養(yǎng)試驗，進(jìn)一步了解其毒性作用，觀察對生長發(fā)育的影響，并可初步估計比較大未觀察到有害作用的劑量。1.蓄積毒性試驗①目的：了解受試物在體內(nèi)的蓄積情況。②試驗項目：包括蓄積系數(shù)法和20天試驗法。蓄積系數(shù)法是用兩種性別的大鼠或小鼠，各20只。江蘇致畸毒理學(xué)安全性評價分析服務(wù)</p><p style="text-indent:25px">江蘇局部毒理學(xué)安全性評價實驗服務(wù)</p><p style="text-indent:25px">【題名】蝦青素的毒理學(xué)安全性評價【作者】劉敏胡嘉想秦光和景簫王偉【機構(gòu)】云南省疾病預(yù)防控制中心,云南昆明650022【刊名】毒理學(xué)雜志, 2008(3): 244-246【關(guān)鍵詞】蝦青素 LD50 遺傳毒性 Ames試驗精子畸形微核【文摘】蝦青素（Astaxanthin）是一種天然的類胡蘿卜素，它的分子式為C40H52O4與β-胡蘿卜素（Beta-carotene）相似，分子式為C40H52。在一些體外試驗中，蝦青素具有較β-胡蘿卜素更強的抗氧化性，同時它也是一種天然色素，作為飼料添加劑應(yīng)用于畜牧飼養(yǎng)業(yè)和水產(chǎn)養(yǎng)殖業(yè)。另外，有研究表明，蝦青素在動物實驗?zāi)Ｐ椭杏?**的作用。但迄今為止，未見有關(guān)蝦青素毒理學(xué)安全性的研究報道。本研究對蝦青素進(jìn)行了急性毒性和遺傳毒性試驗，旨在評估其食用安全性，為蝦青素在食品和在養(yǎng)殖業(yè)中的應(yīng)用提供實驗依據(jù)。江蘇局部毒理學(xué)安全性評價實驗服務(wù)</p><p style="text-indent:25px">上海朝瑞生物科技有限公司是一家1.發(fā)布科研技術(shù) 2.發(fā)布應(yīng)用技術(shù) 3.發(fā)布專業(yè)專長 4.發(fā)布科研成果 5.發(fā)布我的需求 6.發(fā)布篩選檢驗檢測服務(wù) 7.發(fā)布協(xié)同代研發(fā)服務(wù) 8.發(fā)布升級改造產(chǎn)品服務(wù) 9.發(fā)布實驗室及儀器設(shè)備共享 10.發(fā)布培訓(xùn)基地共享 11.發(fā)布工廠代加工及共享車間 12.發(fā)布科研/項目團(tuán)隊招聘13.發(fā)布研究生婚戀 14.發(fā)布項目整包服務(wù) 15.發(fā)布資源交換業(yè)務(wù)的公司，致力于成為客戶業(yè)務(wù)創(chuàng)新、化工可信賴的合作伙伴。上海朝瑞科技擁有一支經(jīng)驗豐富、技術(shù)創(chuàng)新的專業(yè)研發(fā)團(tuán)隊，以高度的專注和執(zhí)著為客戶提供[ "科研技術(shù)服務(wù)", "應(yīng)用技術(shù)服務(wù)", "科研成果轉(zhuǎn)化", "科學(xué)產(chǎn)品銷售" ]。依托效率源扎實的技術(shù)積累、完善的產(chǎn)品體系、深厚的行業(yè)基礎(chǔ)，目前擁有員工數(shù)5~10人，年營業(yè)額達(dá)到2000-3000萬元。上海朝瑞科技始終關(guān)注化工市場，以敏銳的市場洞察力以準(zhǔn)確定位，實現(xiàn)與客戶的成長共贏。</p></p><br /><p>文章來源地址: http://www.cdcfah.com/cp/518543.html</p></div></div></div></div></div><div id="s3e37l4" class="page-right twoColRt"><div id="zdaxubd" class="box01 margin10 clearfix"><h3><a href="http://www.cdcfah.com/cp/">猜你喜歡</a></h3><div id="dnkcu3z" class="recomPic likePro"><a href="http://www.cdcfah.com/cp/814588.html"><div><img src="http://tyunfile.71360.com/UpLoadFile/2019/11/1/14/637082168864691056_lgpj_5374157.jpg" alt="福建ZF配件哪家強信息推薦自業(yè)物資供應(yīng)" class="vcenter" onerror="javascript:this.src='/static/new_net_01/images/nopic.jpg';"></div><p>福建ZF配件哪家強信息推薦自業(yè)物資供應(yīng)</p></a></div><div id="2dseb3m" class="recomPic likePro"><a href="http://www.cdcfah.com/cp/846569.html"><div><img src="https://tyunfile.71360.com/WaterMark/UploadFile/nbzxsw/637298235378037109/764794.png" 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