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onerror="javascript:this.src='/static/new_net_01/images/nopic.jpg';"></p></div></div><div id="cv8a32i" class="smallimg"><div><p class="pic"><img src="http://tyunfile.71360.com/UploadFile/shchaorui/637129699852187500/2173424.png" class="vcenter" onerror="javascript:this.src='/static/new_net_01/images/nopic.jpg';"></p></div></div></div><div id="irlczgs" class="content"><p><span>需求數(shù)量：</span>0</p><p><span>價格要求：</span>面議</p><p><span>所在地：</span>上海市</p><p><span>包裝要求：</span><span style="color: #f30;"></span></p><p><span>產(chǎn)品關(guān)鍵詞：</span>上海毒理學(xué)安全性評價檢測服務(wù),毒理學(xué)安全性評價</p><p><span>***更新：</span>2020-07-07 15:25:19</p><p><span id="click" >瀏覽次數(shù)：0次</span></p><a rel="nofollow" class="button">聯(lián)系我們</a></div></div><div id="f8j3xzl" class="rightbox"><h3>公司基本資料信息</h3><p style="border:0;"><a rel="nofollow">上海朝瑞生物科技有限公司</a></p><p><span>聯(lián)系人：</span>仲先生</p><p><span>郵箱: </span>scienceladder@163.com</p><p><span>電話: </span>18621867065</p><p><span>傳真: </span>021_</p><p><span>網(wǎng)址: </span></p><p><span>手機(jī): </span>021-54133071</p><p><span>地址: </span>上海市松江區(qū)廣富林路697號昂立大廈2113室</p><p>[當(dāng)前離線] <a rel="nofollow"> [加為商友] </a><a rel="nofollow"> [發(fā)送信件] </a></p></div></div><div id="zdvhe8d" class="page-proshow02"><p class="title">詳細(xì)說明</p><div id="q2uwtvx" class="box"><p><p style="text-indent:25px">本次大會歷時3天，參會**達(dá)540人（參會人數(shù)創(chuàng)了本專業(yè)委員會近幾年學(xué)術(shù)大會的新高），基本涵蓋了國家食品藥品監(jiān)督管理總局、國家藥審中心，上海毒理學(xué)安全性評價檢測服務(wù)、國家食品藥品審核查驗(yàn)中心、中國大部分GLP機(jī)構(gòu)、藥檢藥理毒理、大學(xué)科研機(jī)構(gòu)、制藥企業(yè)等專業(yè)領(lǐng)域，其中有50余家GLP機(jī)構(gòu)參加本次大會。另外多家企事業(yè)單位給本次大會提供了幫助和支持，使得本次大會得以順利圓滿的完成。本屆大會共收到學(xué)術(shù)論文摘要近234篇，涵蓋中藥毒理學(xué)科前沿、中藥天然***國際化策略、國家政策法規(guī)，上海毒理學(xué)安全性評價檢測服務(wù)、民族藥毒理、中藥臨床安全性評價等多方面的內(nèi)容。本次大會充分發(fā)揮了報告老師的傳、幫、帶作用，參會**認(rèn)真聽講，積極發(fā)言、熱烈討論，休會期間還就科研協(xié)作、信息交流，上海毒理學(xué)安全性評價檢測服務(wù)，試驗(yàn)平臺的共享等事宜進(jìn)行了熱烈、***的交流，為以后進(jìn)一步促進(jìn)相關(guān)領(lǐng)域的學(xué)術(shù)研究提供了重要的基礎(chǔ)。上海毒理學(xué)安全性評價檢測服務(wù)</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="上海毒理學(xué)安全性評價檢測服務(wù),毒理學(xué)安全性評價" src="http://tyunfile.71360.com/UploadFile/shchaorui/637129699852187500/2173424.png"></div><p> 過體外試驗(yàn)、動物試驗(yàn)和人群觀察，發(fā)現(xiàn)和闡明被評價物質(zhì)（食品或與食品有關(guān)的產(chǎn)品）的毒性和潛在的危害，以便對人類使用這種食品的安全性作出評價，并為制定預(yù)防措施和衛(wèi)生標(biāo)準(zhǔn)提供理論依據(jù)。毒理學(xué)實(shí)驗(yàn)四個階段：第三階段：亞慢性毒性實(shí)驗(yàn)：該階段的主要目的是觀察受試物以不同劑量水平經(jīng)較長期喂養(yǎng)后，對實(shí)驗(yàn)動物的毒性作用性質(zhì)和靶***，了解受試物對動物繁殖及對子代的發(fā)育毒性，觀察對生長發(fā)育的影響，并初步確定比較大未觀察到有害作用的劑量和致*的可能性，同時為慢性毒性和致*試驗(yàn)的劑量選擇提供依據(jù)。代謝試驗(yàn)可以了解受試物在體內(nèi)的吸收、分布和排泄速度以及蓄積性，尋找可能的靶***；為選擇慢性毒性試驗(yàn)的合適動物種、系提供依據(jù)，了解代謝產(chǎn)物的形成情況。實(shí)驗(yàn)期在3個月左右。北京毒代動力毒理學(xué)安全性評價實(shí)驗(yàn)服務(wù)</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="上海毒理學(xué)安全性評價檢測服務(wù),毒理學(xué)安全性評價" src="http://tyunfile.71360.com/UploadFile/shchaorui/637129699860195313/6283991.png"></div><p> 20天試驗(yàn)法是用兩種性別的大鼠或小鼠，每個劑量組雌雄各10只、以上兩種方法任選一種。③結(jié)果判定：蓄積系數(shù)小于3，則放棄，不再繼續(xù)試驗(yàn)；大于或者等于3，則可進(jìn)入以下的試驗(yàn)。如果1/20LD50組有死亡，且有劑量——效應(yīng)關(guān)系，則認(rèn)為有較強(qiáng)的蓄積作用，予以放棄；如1/20LD50組無死亡，則可進(jìn)入以下的試驗(yàn)。2.致突變試驗(yàn)①目的：對受試物是否具有致*作用的可能性進(jìn)行篩選。②試驗(yàn)項(xiàng)目：包括體外試驗(yàn)與整體試驗(yàn)。體外試驗(yàn)中細(xì)菌回復(fù)突變實(shí)驗(yàn)（Ames試驗(yàn)）為必做項(xiàng)目。在整體試驗(yàn)中，可在微核試驗(yàn)和骨髓細(xì)胞染色體畸變分析試驗(yàn)中任選一項(xiàng)；在顯性致死試驗(yàn)和睪丸生殖細(xì)胞染色體畸變分析試驗(yàn)中任選一項(xiàng)。③結(jié)果判定：Ⅰ如三項(xiàng)試驗(yàn)均為陽性，則表示受試物很有可能具有致*作用，除非受試物具有十分重要的價值，一般應(yīng)予以放棄；Ⅱ如其中兩項(xiàng)試驗(yàn)為陽性，則由有關(guān)**進(jìn)行評議，根據(jù)受試物的重要性和可能攝入量等，綜合權(quán)衡利弊再作出決定；Ⅲ如其中一項(xiàng)試驗(yàn)為陽性，則再選擇兩項(xiàng)其他致突變試驗(yàn)。包括體外培養(yǎng)淋巴細(xì)胞染色畸變分析、DNA修復(fù)合成、DNA合成***、姐妹染色單體互換試驗(yàn)等）。如此兩項(xiàng)均為陽性，則應(yīng)予放棄；如有一項(xiàng)為陽性，則可進(jìn)入亞慢性毒性試驗(yàn)。</p><p> 安全毒理學(xué)評價編輯鎖定討論本詞條由“科普中國”科學(xué)百科詞條編寫與應(yīng)用工作項(xiàng)目審核。通過體外試驗(yàn)、動物試驗(yàn)和人群觀察，發(fā)現(xiàn)和闡明被評價物質(zhì)（食品或與食品有關(guān)的產(chǎn)品）的毒性和潛在的危害，以便對人類使用這種食品的安全性作出評價，并為制定預(yù)防措施和衛(wèi)生標(biāo)準(zhǔn)提供理論依據(jù)。中文名食品安全性毒理學(xué)評價外文名Foodsafetytoxicologyevaluation目錄1定義2相關(guān)法律法規(guī)3準(zhǔn)備工作4選用原則5主要內(nèi)容和程序?（1）***階段急性毒性試驗(yàn)?（2）第二階段遺傳毒性試驗(yàn)?（3）第三階段亞慢性毒性試驗(yàn)?（4）第四階段慢性毒性試驗(yàn)6應(yīng)用安全毒理學(xué)評價定義編輯食品安全性毒理學(xué)評價是運(yùn)用現(xiàn)代毒理學(xué)理論，并結(jié)合流行病學(xué)調(diào)查分析和闡明食品或食品中的特定物質(zhì)的毒性及其潛在危害，預(yù)測人體接觸后可能對人體健康產(chǎn)生影響的性質(zhì)和強(qiáng)度，提出食用安全風(fēng)險和預(yù)防措施的一門技術(shù)。[1]安全毒理學(xué)評價相關(guān)法律法規(guī)編輯（1）《食品安全性毒理學(xué)評價程序》；（2）《農(nóng)藥安全性毒理學(xué)評價程序》；（3）《新藥（西藥）毒理學(xué)研究指導(dǎo)原則》；（4）《化妝品安全性評價程序和方法》；（5）《食品功能毒理學(xué)評價程序和檢驗(yàn)方法》；。6）《食品毒理學(xué)實(shí)驗(yàn)室操作規(guī)范》安全毒理學(xué)評價準(zhǔn)備工作編輯。</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="上海毒理學(xué)安全性評價檢測服務(wù),毒理學(xué)安全性評價" src="http://tyunfile.71360.com/UploadFile/shchaorui/637129699845576172/4944147.png"></div><p> 經(jīng)口半數(shù)致死量），了解受試物的毒性強(qiáng)度、性質(zhì)和可能的靶***，為進(jìn)一步進(jìn)行毒性試驗(yàn)的劑量和毒性觀察指標(biāo)的選擇提供依據(jù)，并根據(jù)LD50進(jìn)行毒性分級。試驗(yàn)項(xiàng)目：①霍恩氏法、機(jī)率單位法或寇氏法測定經(jīng)口半數(shù)致死量（LD50）；②7天喂養(yǎng)試驗(yàn)。以上兩個項(xiàng)目分別用兩種性別的小鼠和（或）大鼠進(jìn)行結(jié)果判定：①LD50或7天喂養(yǎng)試驗(yàn)的**小有作用劑量小于人的可能攝入量的10倍者，則放棄不再繼續(xù)試驗(yàn)；②大于10倍者，可進(jìn)入下一階段試驗(yàn)。為慎重起見，凡LD50在10倍左右時，應(yīng)進(jìn)行重復(fù)試驗(yàn)，或用另一種方法進(jìn)行驗(yàn)證。[2]安全毒理學(xué)評價（2）第二階段遺傳毒性試驗(yàn)考慮原核細(xì)胞與真核細(xì)胞、體內(nèi)試驗(yàn)和體外試驗(yàn)相結(jié)合的原則選擇試驗(yàn)組合，對受試物的遺傳毒性以及是否具有潛在致*作用進(jìn)行篩選。食品毒理學(xué)中的傳統(tǒng)致畸試驗(yàn)是限定于受孕動物的觀察，了解受試物是否具有致畸作用。在急性毒性試驗(yàn)的基礎(chǔ)上，通過30天喂養(yǎng)試驗(yàn)，進(jìn)一步了解其毒性作用，觀察對生長發(fā)育的影響，并可初步估計(jì)比較大未觀察到有害作用的劑量。1.蓄積毒性試驗(yàn)①目的：了解受試物在體內(nèi)的蓄積情況。②試驗(yàn)項(xiàng)目：包括蓄積系數(shù)法和20天試驗(yàn)法。蓄積系數(shù)法是用兩種性別的大鼠或小鼠，各20只。上海給藥毒理學(xué)安全性評價檢測分析</p><p style="text-indent:25px">上海毒理學(xué)安全性評價檢測服務(wù)</p><p> 擴(kuò)展資料：一、食品安全性毒理學(xué)評價實(shí)驗(yàn)項(xiàng)目；***階段：急性毒性試驗(yàn)，試驗(yàn)項(xiàng)目：1.用霍恩氏法、機(jī)率單位法或寇氏法，測定經(jīng)口半數(shù)致死量（LD50）。如劑量達(dá)10克/公斤體重仍不引起動物死亡，則不必測定半數(shù)致死量。2.必要時進(jìn)行七天喂養(yǎng)試驗(yàn)。以上兩個項(xiàng)目均分別用兩種性別的小鼠或大鼠。第二階段：蓄積毒性和致突變試驗(yàn)，試驗(yàn)項(xiàng)目：1.蓄積系數(shù)法。用兩種性別的大鼠或小鼠，各20只。2.二十天試驗(yàn)法。用兩種性別的大鼠或小鼠，每個劑量組雌雄各10只。以上兩種方法任選一種。第三階段：亞慢性毒性（包括繁殖、致畸）試驗(yàn)和代謝試驗(yàn)，試驗(yàn)項(xiàng)目：。2.喂養(yǎng)繁殖試驗(yàn)。3.喂養(yǎng)致畸試驗(yàn)。4.傳統(tǒng)致畸試驗(yàn)。第四階段：慢性毒性（包括致*）試驗(yàn)，試驗(yàn)項(xiàng)目：可將兩年慢性毒性試驗(yàn)和致*試驗(yàn)結(jié)合在一個動物試驗(yàn)中進(jìn)行。用兩種性別的大鼠或小鼠。二：食品安全性毒理學(xué)評價實(shí)驗(yàn)要求：1、凡屬我國創(chuàng)制的新化學(xué)物質(zhì)，一般要求進(jìn)行四個階段的試驗(yàn)。特別是對其中化學(xué)結(jié)構(gòu)提示有慢性毒性或致*作用可能者，產(chǎn)量大、使用面積廣、攝入機(jī)會多者，必需進(jìn)行全部四個階段的試驗(yàn)。2、凡屬與已知物質(zhì)（指經(jīng)過安全性評價并允許使用者）的化學(xué)結(jié)構(gòu)基本相同的衍生物，則可根據(jù)***、二、三階段試驗(yàn)的結(jié)果。上海毒理學(xué)安全性評價檢測服務(wù)</p><p style="text-indent:25px">上海朝瑞生物科技有限公司始建于2003-01-22，坐落于上海市松江區(qū)廣富林路697號昂立大廈2113室，現(xiàn)有員工5~10人余人。致力于創(chuàng)造***的產(chǎn)品與服務(wù)，以誠信、敬業(yè)、進(jìn)取為宗旨，以建zrbiorise,SPRICELL,scienceladde明星產(chǎn)品為目標(biāo)，努力打造成為同行業(yè)中具有影響力的企業(yè)。公司以用心服務(wù)為**價值,希望通過我們的專業(yè)水平和不懈努力,將1.發(fā)布科研技術(shù) 2.發(fā)布應(yīng)用技術(shù) 3.發(fā)布專業(yè)專長 4.發(fā)布科研成果 5.發(fā)布我的需求 6.發(fā)布篩選檢驗(yàn)檢測服務(wù) 7.發(fā)布協(xié)同代研發(fā)服務(wù) 8.發(fā)布升級改造產(chǎn)品服務(wù) 9.發(fā)布實(shí)驗(yàn)室及儀器設(shè)備共享 10.發(fā)布培訓(xùn)基地共享 11.發(fā)布工廠代加工及共享車間 12.發(fā)布科研/項(xiàng)目團(tuán)隊(duì)招聘13.發(fā)布研究生婚戀 14.發(fā)布項(xiàng)目整包服務(wù) 15.發(fā)布資源交換業(yè)務(wù)等業(yè)務(wù)進(jìn)行到底。上海朝瑞科技始終以質(zhì)量為發(fā)展，把顧客的滿意作為公司發(fā)展的動力，致力于為顧客帶來***的[ "科研技術(shù)服務(wù)", "應(yīng)用技術(shù)服務(wù)", "科研成果轉(zhuǎn)化", "科學(xué)產(chǎn)品銷售" ]。</p></p><br /><p>文章來源地址: http://www.cdcfah.com/cp/525428.html</p></div></div></div></div></div><div id="ts2crnz" class="page-right twoColRt"><div id="gvczwnp" class="box01 margin10 clearfix"><h3><a 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