上海局部毒理學(xué)安全性評價(jià) 歡迎來電上海朝瑞生物科技供應(yīng)-b2b網(wǎng)站_b2b電子商務(wù)平臺【買產(chǎn)品】-上?？谄蚴称酚邢薰?/title><meta name="description" content=" 過體外試驗(yàn)、動物試驗(yàn)和人群觀察，上海局部毒理學(xué)安全性評價(jià)，發(fā)現(xiàn)和闡明被評價(jià)物質(zhì)（食品或與食品有關(guān)的產(chǎn)品）的毒性和潛在的危害，以便對人類使用這種食品的安全性作出評價(jià)，并為制定預(yù)防措施和衛(wèi)生標(biāo)準(zhǔn)提"><meta name="keywords" content="上海局部毒理學(xué)安全性評價(jià),毒理學(xué)安全性評價(jià)"><link rel="canonical" href="http://www.cdcfah.com/"/><meta name="applicable-device" content="pc"><link rel="shortcut icon" href="/static/new_net_01/images/favicon.ico"><link rel="stylesheet" href="/static/new_net_01/css/slick.css" /><link rel="stylesheet" href="/static/new_net_01/css/addnew.css"><link rel="stylesheet" href="/static/new_net_01/css/sidenav.css"><link rel="stylesheet" href="/static/new_net_01/css/style.css" /><link rel="stylesheet" href="/static/new_net_01/css/tab.css"><link rel="stylesheet" href="/static/new_net_01/css/404.css"> <meta name="baidu-site-verification" content="OBVzrC9aaQ" /> <meta 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歡迎來電上海朝瑞生物科技供應(yīng)</h1><div id="rv8kc4b" class="proBig"><div id="azros9x" class="bigimg"><div><p class="pic"><img src="http://tyunfile.71360.com/UploadFile/shchaorui/637129699860195313/6283991.png" class="vcenter" onerror="javascript:this.src='/static/new_net_01/images/nopic.jpg';"></p></div></div><div id="z8wd8pe" class="smallimg"><div><p class="pic"><img src="http://tyunfile.71360.com/UploadFile/shchaorui/637129699860195313/6283991.png" class="vcenter" onerror="javascript:this.src='/static/new_net_01/images/nopic.jpg';"></p></div></div></div><div id="t2dpe4k" class="content"><p><span>需求數(shù)量：</span>0</p><p><span>價(jià)格要求：</span>面議</p><p><span>所在地：</span>上海市</p><p><span>包裝要求：</span><span style="color: #f30;"></span></p><p><span>產(chǎn)品關(guān)鍵詞：</span>上海局部毒理學(xué)安全性評價(jià),毒理學(xué)安全性評價(jià)</p><p><span>***更新：</span>2020-07-23 16:18:40</p><p><span id="click" >瀏覽次數(shù)：0次</span></p><a rel="nofollow" class="button">聯(lián)系我們</a></div></div><div id="bqceq97" class="rightbox"><h3>公司基本資料信息</h3><p style="border:0;"><a rel="nofollow">上海朝瑞生物科技有限公司</a></p><p><span>聯(lián)系人：</span>仲先生</p><p><span>郵箱: </span>scienceladder@163.com</p><p><span>電話: </span>18621867065</p><p><span>傳真: </span>021_</p><p><span>網(wǎng)址: </span></p><p><span>手機(jī): </span>021-54133071</p><p><span>地址: </span>上海市松江區(qū)廣富林路697號昂立大廈2113室</p><p>[當(dāng)前離線] <a rel="nofollow"> [加為商友] </a><a rel="nofollow"> [發(fā)送信件] </a></p></div></div><div id="oszgdco" class="page-proshow02"><p class="title">詳細(xì)說明</p><div id="qk7km9q" class="box"><p><p> 過體外試驗(yàn)、動物試驗(yàn)和人群觀察，上海局部毒理學(xué)安全性評價(jià)，發(fā)現(xiàn)和闡明被評價(jià)物質(zhì)（食品或與食品有關(guān)的產(chǎn)品）的毒性和潛在的危害，以便對人類使用這種食品的安全性作出評價(jià)，并為制定預(yù)防措施和衛(wèi)生標(biāo)準(zhǔn)提供理論依據(jù)。毒理學(xué)實(shí)驗(yàn)四個階段：第三階段：亞慢性毒性實(shí)驗(yàn)：該階段的主要目的是觀察受試物以不同劑量水平經(jīng)較長期喂養(yǎng)后，對實(shí)驗(yàn)動物的毒性作用性質(zhì)和靶***，了解受試物對動物繁殖及對子代的發(fā)育毒性，觀察對生長發(fā)育的影響，并初步確定比較大未觀察到有害作用的劑量和致*的可能性，同時為慢性毒性和致*試驗(yàn)的劑量選擇提供依據(jù)。代謝試驗(yàn)可以了解受試物在體內(nèi)的吸收、分布和排泄速度以及蓄積性，上海局部毒理學(xué)安全性評價(jià)，尋找可能的靶***；為選擇慢性毒性試驗(yàn)的合適動物種，上海局部毒理學(xué)安全性評價(jià)、系提供依據(jù)，了解代謝產(chǎn)物的形成情況。實(shí)驗(yàn)期在3個月左右。上海局部毒理學(xué)安全性評價(jià)</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="上海局部毒理學(xué)安全性評價(jià),毒理學(xué)安全性評價(jià)" src="http://tyunfile.71360.com/UploadFile/shchaorui/637129699860195313/6283991.png"></div><p> 1）收集化學(xué)物質(zhì)有關(guān)的基本資料；（2）了解化學(xué)物質(zhì)的使用情況；（3）選用人類實(shí)際接觸和應(yīng)用的產(chǎn)品形式進(jìn)行實(shí)驗(yàn)；（4）選擇實(shí)驗(yàn)動物的要求。安全毒理學(xué)評價(jià)選用原則編輯（1）凡屬我國創(chuàng)新的受試物一般要求進(jìn)行四個階段的試驗(yàn)，特別是對其中化學(xué)結(jié)構(gòu)提示有慢性毒性、遺傳毒性或致*性可能者或產(chǎn)量大、使用范圍廣、攝入機(jī)會者多，必須進(jìn)行全部四個階段的毒性試驗(yàn)。（2）凡屬與已知物質(zhì)（指經(jīng)過安全性評價(jià)并允許使用者）的化學(xué)結(jié)構(gòu)基本相同的衍生物或類似物，則根據(jù)一、二、三階段毒性試驗(yàn)結(jié)果判斷是否需要進(jìn)行第四階段試驗(yàn)。（3）凡屬已知的化學(xué)物質(zhì)，世界衛(wèi)生組織對其已公布每人每日允許攝入量（ADI）的，同時申請單位又有資料證明我國產(chǎn)品的質(zhì)量規(guī)格與國外產(chǎn)品一致，則可先進(jìn)行***、二階段試驗(yàn)。如果產(chǎn)品質(zhì)量或者試驗(yàn)結(jié)果與國外資料一致，一般不要求進(jìn)一步的毒性試驗(yàn)，否則應(yīng)進(jìn)行第三階段試驗(yàn)。（4）農(nóng)藥、食品添加劑、食品新資源和新資源食品、輻照食品、食品工具以及設(shè)備用清洗消毒劑的安全性毒理學(xué)評價(jià)試驗(yàn)選擇應(yīng)分別符合規(guī)定要求。安全毒理學(xué)評價(jià)主要內(nèi)容和程序編輯毒理學(xué)試驗(yàn)分為4個階段：安全毒理學(xué)評價(jià)（1）***階段急性毒性試驗(yàn)?zāi)康模罕驹囼?yàn)測定LD50。江蘇毒代動力毒理學(xué)安全性評價(jià)</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="上海局部毒理學(xué)安全性評價(jià),毒理學(xué)安全性評價(jià)" src="http://tyunfile.71360.com/UploadFile/shchaorui/637129699835605469/3930676.png"></div><p> 擴(kuò)展資料：一、食品安全性毒理學(xué)評價(jià)實(shí)驗(yàn)項(xiàng)目；***階段：急性毒性試驗(yàn)，試驗(yàn)項(xiàng)目：1.用霍恩氏法、機(jī)率單位法或寇氏法，測定經(jīng)口半數(shù)致死量（LD50）。如劑量達(dá)10克/公斤體重仍不引起動物死亡，則不必測定半數(shù)致死量。2.必要時進(jìn)行七天喂養(yǎng)試驗(yàn)。以上兩個項(xiàng)目均分別用兩種性別的小鼠或大鼠。第二階段：蓄積毒性和致突變試驗(yàn)，試驗(yàn)項(xiàng)目：1.蓄積系數(shù)法。用兩種性別的大鼠或小鼠，各20只。2.二十天試驗(yàn)法。用兩種性別的大鼠或小鼠，每個劑量組雌雄各10只。以上兩種方法任選一種。第三階段：亞慢性毒性（包括繁殖、致畸）試驗(yàn)和代謝試驗(yàn)，試驗(yàn)項(xiàng)目：。2.喂養(yǎng)繁殖試驗(yàn)。3.喂養(yǎng)致畸試驗(yàn)。4.傳統(tǒng)致畸試驗(yàn)。第四階段：慢性毒性（包括致*）試驗(yàn)，試驗(yàn)項(xiàng)目：可將兩年慢性毒性試驗(yàn)和致*試驗(yàn)結(jié)合在一個動物試驗(yàn)中進(jìn)行。用兩種性別的大鼠或小鼠。二：食品安全性毒理學(xué)評價(jià)實(shí)驗(yàn)要求：1、凡屬我國創(chuàng)制的新化學(xué)物質(zhì)，一般要求進(jìn)行四個階段的試驗(yàn)。特別是對其中化學(xué)結(jié)構(gòu)提示有慢性毒性或致*作用可能者，產(chǎn)量大、使用面積廣、攝入機(jī)會多者，必需進(jìn)行全部四個階段的試驗(yàn)。2、凡屬與已知物質(zhì)（指經(jīng)過安全性評價(jià)并允許使用者）的化學(xué)結(jié)構(gòu)基本相同的衍生物，則可根據(jù)***、二、三階段試驗(yàn)的結(jié)果。</p><p style="text-indent:25px">食品安全性毒理學(xué)評價(jià)是運(yùn)用現(xiàn)代毒理學(xué)理論，并結(jié)合流行病學(xué)調(diào)查分析和闡明食品或食品中的特定物質(zhì)的毒性及其潛在危害，預(yù)測人體接觸后可能對人體健康產(chǎn)生影響的性質(zhì)和強(qiáng)度，提出食用安全風(fēng)險(xiǎn)和預(yù)防措施的一門技術(shù)。 [1] 相關(guān)法律法規(guī)編輯（1）《食品安全性毒理學(xué)評價(jià)程序》；（2）《農(nóng)藥安全性毒理學(xué)評價(jià)程序》；（3）《新藥（西藥）毒理學(xué)研究指導(dǎo)原則》；（4）《化妝品安全性評價(jià)程序和方法》；（5）《食品功能毒理學(xué)評價(jià)程序和檢驗(yàn)方法》；（6）《食品毒理學(xué)實(shí)驗(yàn)室操作規(guī)范》。</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="上海局部毒理學(xué)安全性評價(jià),毒理學(xué)安全性評價(jià)" src="http://tyunfile.71360.com/UploadFile/shchaorui/637129699841435547/3737546.png"></div><p style="text-indent:25px">本次大會邀請了中國工程院院士周宏灝教授、國家食品藥品監(jiān)督管理總局趙陽處長、國家食品藥品監(jiān)督管理總局食品藥品審核查驗(yàn)中心李見明副主任、國家食品藥品監(jiān)督管理總局藥品審評中心藥理毒理部王慶利部長、國家認(rèn)監(jiān)委吳孝槐博士、國際GLP委員會受邀行業(yè)**Chris 博士等11位國際國內(nèi)*****毒理研究監(jiān)管**和技術(shù)**做了精彩的大會特邀報(bào)告，特邀報(bào)告讓參會人員受益匪淺，**開闊了研究視野。大會學(xué)術(shù)委員會組織**從234篇投稿論文中選拔了28位********毒理研究**、法規(guī)**進(jìn)行了分會場報(bào)告，選拔了16位青年毒理學(xué)工作者參加了本次大會“青年***論文獎”的評選，其中10位獲得了***論文口頭報(bào)告獎，他們的精彩發(fā)言和完美展示，給與會者留下了深刻的印象。演講**分別從“國際國內(nèi)GLP規(guī)范的現(xiàn)狀、修訂與實(shí)施***動向，新藥安全性評價(jià)與評審新舉措，中國GLP國際化、GLP法規(guī)，***毒理學(xué)研究的前言和***進(jìn)展，***臨床前安全性評價(jià)新思路、新技術(shù)、新方法”等方面做了精彩的報(bào)告，給參會者奉獻(xiàn)了豐盛的***毒理與安全性評價(jià)學(xué)術(shù)盛宴。江蘇毒代動力毒理學(xué)安全性評價(jià)</p><p style="text-indent:25px">上海局部毒理學(xué)安全性評價(jià)</p><p> 過體外試驗(yàn)、動物試驗(yàn)和人群觀察，發(fā)現(xiàn)和闡明被評價(jià)物質(zhì)（食品或與食品有關(guān)的產(chǎn)品）的毒性和潛在的危害，以便對人類使用這種食品的安全性作出評價(jià)，并為制定預(yù)防措施和衛(wèi)生標(biāo)準(zhǔn)提供理論依據(jù)。毒理學(xué)實(shí)驗(yàn)四個階段： </p> <p> <p> 第二階段：遺傳毒性試驗(yàn)，30 天喂養(yǎng)試驗(yàn)，傳統(tǒng)致畸試驗(yàn) </p> <p> 遺傳毒性試驗(yàn)的組合應(yīng)該考慮原核細(xì)胞與真核細(xì)胞、體內(nèi)試驗(yàn)與體外試驗(yàn)相結(jié)合的原則。從Ames 試驗(yàn)或V79/HGPRT 基因突變試驗(yàn)、骨髓細(xì)胞微核試驗(yàn)或哺乳動物骨髓細(xì)胞染色體畸變試驗(yàn)、TK 基因突變試驗(yàn)或小鼠精子畸形分析（或睪丸染色體畸變分析試驗(yàn)）中分別各選一項(xiàng)。 </p> 上海局部毒理學(xué)安全性評價(jià)</p><p style="text-indent:25px">上海朝瑞生物科技有限公司成立于2003-01-22，專業(yè)1.發(fā)布科研技術(shù) 2.發(fā)布應(yīng)用技術(shù) 3.發(fā)布專業(yè)專長 4.發(fā)布科研成果 5.發(fā)布我的需求 6.發(fā)布篩選檢驗(yàn)檢測服務(wù) 7.發(fā)布協(xié)同代研發(fā)服務(wù) 8.發(fā)布升級改造產(chǎn)品服務(wù) 9.發(fā)布實(shí)驗(yàn)室及儀器設(shè)備共享 10.發(fā)布培訓(xùn)基地共享 11.發(fā)布工廠代加工及共享車間 12.發(fā)布科研/項(xiàng)目團(tuán)隊(duì)招聘13.發(fā)布研究生婚戀 14.發(fā)布項(xiàng)目整包服務(wù) 15.發(fā)布資源交換業(yè)務(wù)等多項(xiàng)業(yè)務(wù)，主營業(yè)務(wù)涵蓋[ "科研技術(shù)服務(wù)", "應(yīng)用技術(shù)服務(wù)", "科研成果轉(zhuǎn)化", "科學(xué)產(chǎn)品銷售" ]。公司目前擁有高技術(shù)人才5~10人人，以不斷增強(qiáng)企業(yè)核心競爭力，加快企業(yè)技術(shù)創(chuàng)新，實(shí)現(xiàn)穩(wěn)健生產(chǎn)經(jīng)營。公司業(yè)務(wù)范圍主要包括：[ "科研技術(shù)服務(wù)", "應(yīng)用技術(shù)服務(wù)", "科研成果轉(zhuǎn)化", "科學(xué)產(chǎn)品銷售" ]等。公司奉行顧客至上、質(zhì)量為首、的經(jīng)營宗旨，深受客戶好評。公司力求給客戶提供***質(zhì)量服務(wù)，我們相信誠實(shí)正直、開拓進(jìn)取地為公司發(fā)展做正確的事情，將為公司和個人帶來共同的利益和進(jìn)步。經(jīng)過幾年的發(fā)展，已成為[ "科研技術(shù)服務(wù)", 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