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注冊(cè)加入HCBBS工業(yè)人社群，結(jié)交更多工業(yè)圈好友您需要登錄才可以下載或查看，沒(méi)有帳號(hào)？注冊(cè)x一、**技術(shù)擁有微生物菌種資源庫(kù)和集成化菌株選育系統(tǒng)**研發(fā)的集成化菌株選育系統(tǒng)能在數(shù)天內(nèi)完成千余菌株的篩選,效率傳統(tǒng)篩選手段提高數(shù)百倍.從國(guó)外積累了龐大的來(lái)自各種極端環(huán)境的微生物資源庫(kù)，北京中藥微生物菌種定向改良工藝服務(wù),細(xì)菌種高達(dá)1000多種,菌株持有量十萬(wàn)余株.集成菌株選育系統(tǒng)已經(jīng)成功為精細(xì)化工、采油、餐廚垃圾處理、制藥化工、印染、農(nóng)產(chǎn)品加工等行業(yè)的多家企業(yè)提供了污水處理的***菌種及配套工藝.二、業(yè)務(wù)范圍1、高鹽度有機(jī)廢水生化處理含鹽量(NaCl)高達(dá)8%及飽和Na2SO4的廢水;DMF含量≤5%的有機(jī)廢水。2、利用特種微生物，對(duì)已有的生化系統(tǒng)進(jìn)行改造，北京中藥微生物菌種定向改良工藝服務(wù)，可穩(wěn)定系統(tǒng)運(yùn)行，縮短運(yùn)行周期，降低運(yùn)行成本。3，北京中藥微生物菌種定向改良工藝服務(wù)、幫助企業(yè)運(yùn)行生化系統(tǒng)或指導(dǎo)企業(yè)運(yùn)行生化系統(tǒng)三、案例介紹江蘇鹽城某上市制藥企業(yè)存在問(wèn)題:該企業(yè)廢水屬于典型的制藥化工廢水,原有系統(tǒng)采用酸化水解+AAO工藝的方式進(jìn)行處理,但由于廢水生化性能不佳,企業(yè)每日從外部投入大量的活性污泥才能勉強(qiáng)保持可溶性COD低于500mg/L,但由于投入污泥量過(guò)大,導(dǎo)致泥水分離效果極差,SV30>95%,實(shí)際出水口因混入污泥,在線檢測(cè)結(jié)果超過(guò)三級(jí)標(biāo)準(zhǔn)限值。隨機(jī)基因突變并篩選獲得性狀或/和性能改良的正向突變菌文庫(kù)。北京中藥微生物菌種定向改良工藝服務(wù)</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="北京中藥微生物菌種定向改良工藝服務(wù),微生物菌種定向改良" src="http://tyunfile.71360.com/UploadFile/shchaorui/637190230318750000/4095634.png"></div><p> 工廠化高密度養(yǎng)殖,需人工大量投喂飼料,餌料殘余及水產(chǎn)動(dòng)物的排泄物溶解于水中,對(duì)養(yǎng)殖水體造成污染,危害養(yǎng)殖對(duì)象的健康生長(zhǎng).對(duì)魚蝦疾病用***防治只是暫時(shí)性手段,廣譜***殺死或***了敏感細(xì)菌而保留了耐藥的致病菌,破壞或干擾了水體原有的正常微生物區(qū)系的生態(tài)平衡,更增加了養(yǎng)殖動(dòng)物***病菌的機(jī)會(huì),***在生物體內(nèi)的殘留,**終會(huì)對(duì)人體產(chǎn)生危害.微生物應(yīng)用于水產(chǎn)養(yǎng)殖來(lái)改善水體生態(tài)環(huán)境,***殺死病原微生物,并可作為飼料添加劑,補(bǔ)充營(yíng)養(yǎng)成分,改善養(yǎng)殖動(dòng)物胃腸道有益菌群[1-2],達(dá)到生態(tài)防治的目的,使養(yǎng)殖生產(chǎn)良性發(fā)展,取得更好的經(jīng)濟(jì)效益、生態(tài)效益.目前國(guó)內(nèi)外較為普遍應(yīng)用于水產(chǎn)養(yǎng)殖的幾種微生物、微藻類在水處理、防治病原微生物和病害發(fā)生方面的應(yīng)用情況和發(fā)展動(dòng)態(tài)進(jìn)行了分析. </p> <p> <br /> 江蘇工業(yè)微生物菌種定向改良實(shí)驗(yàn)服務(wù)一般具備特征篩選標(biāo)記(如***抗性等)或/和表型(如耐酸、耐熱)的親本更利于后續(xù)的原生質(zhì)體融合及篩選；</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="北京中藥微生物菌種定向改良工藝服務(wù),微生物菌種定向改良" src="http://tyunfile.71360.com/UploadFile/shchaorui/637190230317080078/8967780.png"></div><p> 研究?jī)?nèi)容:主要以酵母菌為材料，構(gòu)建作為基因克隆及表達(dá)的優(yōu)良受體和載體系統(tǒng)并開展基因表達(dá)調(diào)控研究。同時(shí)進(jìn)行酵母細(xì)胞自溶機(jī)理研究。在應(yīng)用基礎(chǔ)研究方面：采用誘變、雜交、融合及基因工程等育種方法，對(duì)有應(yīng)用前景的酵母菌進(jìn)行遺傳育種，選育具有生產(chǎn)價(jià)值的優(yōu)良酵母菌種。 </p> <p> 承擔(dān)課題：國(guó)家"九五"攻關(guān)項(xiàng)目"酵母發(fā)酵法生產(chǎn)麥角固醇"；國(guó)家自然科學(xué)基金面上項(xiàng)目"絮凝性強(qiáng)及熟化期短的啤酒酵母工程菌的研究"；橫向合作項(xiàng)目"熟化期短及絮凝性強(qiáng)的啤酒酵母工程菌的構(gòu)建"。 </p> <p> 研究進(jìn)展：選育到麥角固醇高產(chǎn)酵母菌株YEH－56，麥角固醇含量達(dá)細(xì)胞干重的3％。利用整合載體將醋酸桿菌α-乙酰乳酸脫羧酶基因整合到青島啤酒酵母菌中并獲得表達(dá),目前正在進(jìn)行中試實(shí)驗(yàn)。分離到低滲透敏感突變株和溫度敏感突變株，它們?cè)诘蜐B透介質(zhì)中或高溫下表現(xiàn)出細(xì)胞自溶特性。 </p> <p> 主要成果：本年度在國(guó)內(nèi)外有關(guān)刊物發(fā)表論文5篇，其中SCI收錄刊物論文1篇。 </p><p style="text-indent:25px">于國(guó)家相關(guān)政策的傾斜，一些不具備生產(chǎn)微生物菌劑的企業(yè)也跟風(fēng)上馬，加入到土壤修復(fù)菌劑和微生物菌肥的生產(chǎn)行列。企業(yè)沒(méi)有具有自主知識(shí)產(chǎn)權(quán)的菌種，大都采用外購(gòu)菌種的形式解決生產(chǎn)問(wèn)題，但是不清楚由于微生物個(gè)體很小，與外界環(huán)境的接觸面很大，在人工重復(fù)培養(yǎng)繁殖過(guò)程中極易發(fā)生變異，喪失其原來(lái)的一些特性，特別是野生環(huán)境下的競(jìng)爭(zhēng)存活能力。這樣生產(chǎn)出來(lái)的菌劑產(chǎn)品好比自家養(yǎng)的寵物貓，進(jìn)入自然的生態(tài)環(huán)境后往往自身難保，見了耗子都會(huì)嚇怕的情況下，怎么能抓住耗子。主要采用酶解法去除細(xì)胞壁，因此酶的種類和用量、酶解時(shí)間、溫度和pH等都會(huì)直接影響原生質(zhì)體的質(zhì)量；</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="北京中藥微生物菌種定向改良工藝服務(wù),微生物菌種定向改良" src="http://tyunfile.71360.com/UploadFile/shchaorui/637190230317294922/2104477.png"></div><p> 能有效解決蛋白來(lái)源不足的困境，對(duì)食品工業(yè)的發(fā)展具有極強(qiáng)的推動(dòng)作用。發(fā)展SCP的優(yōu)勢(shì)，解決其存在的不足，降低其存在的風(fēng)險(xiǎn)，對(duì)解決我國(guó)甚至世界存在的人口、食品、環(huán)境、資源等問(wèn)題都大有裨益。大力發(fā)展SCP產(chǎn)業(yè)適合我國(guó)的國(guó)情，具有廣闊的發(fā)展空間。參考文獻(xiàn)[1]MatassaS,BoonN,PikaarI,[J].MicrobBiotechnol,2016,9(5):568-575.[2]郭雪山，肖玫.單細(xì)胞蛋白的應(yīng)用及其開發(fā)前景[J]．中國(guó)食物與營(yíng)養(yǎng)，2006(5):23-24.[3]熊智輝.單細(xì)胞蛋白在飼料業(yè)中的研究進(jìn)展[J]．養(yǎng)殖與飼料，2006(7):11-15.[4]SparkM,PaschertzH,(differentsourcesandlevels)asteinsourceindietsofrearedpiglets:effectsonteindigestibilityandN-metabolism[J].JAnimPhysiolAnimNutr(Berl),2005,89(36):184-188.[5]董衍明，馬雁玲.單細(xì)胞蛋白飼料的開發(fā)與利用[J]．飼料研究，2005(9):25-27.[6]NasseriAT,Rasoul-AmiS,MorowvatMH,[J].AmericanJournalofFoodTechnology,2011,6(2):103-116.[7]AParaskevopoulou,IAthanasiadis,MKanellaki,[J].FoodResearchernational,2003,36(5):431-438.[8][J].BioresourceTechnology,2005,97(2):322-329.[9]HandanUM,NuriA,[J].BrazilianJournalofMicrobiology,2002。此外，在微生物復(fù)雜的基因轉(zhuǎn)錄和代謝網(wǎng)絡(luò)調(diào)控背景下如何確定有效的基因靶標(biāo)也是該技術(shù)的關(guān)鍵瓶頸。上海環(huán)境微生物菌種定向改良耐受性</p><p style="text-indent:25px">經(jīng)過(guò)多輪遞推的原生質(zhì)體融合來(lái)加速其人工定向進(jìn)化；北京中藥微生物菌種定向改良工藝服務(wù)</p><p> 兩者值越高說(shuō)明蛋白質(zhì)質(zhì)量越好。核酸是所有細(xì)胞的必需成分，并且在快速分裂的細(xì)胞中呈現(xiàn)出相對(duì)高的水平，如果攝入過(guò)多RNA就會(huì)導(dǎo)致人體尿酸含量高于安全標(biāo)準(zhǔn)，所以去除SCP產(chǎn)品中的核酸是關(guān)乎安全性的重要問(wèn)題[11]。5、單細(xì)胞蛋白在食品工業(yè)的應(yīng)用前景展望、單細(xì)胞蛋白的應(yīng)用前景(1)SCP含有豐富的蛋白質(zhì)及多種維生素和無(wú)機(jī)鹽，是一種營(yíng)養(yǎng)較為***的理想蛋白質(zhì)來(lái)源，把它摻和在餅干、飲料、奶制品中，能提高這些傳統(tǒng)食品的營(yíng)養(yǎng)價(jià)值;(2)SCP除直接作為食品應(yīng)用外，還可作為一種食品蛋白質(zhì)組分添加到湯料或飲料中強(qiáng)化營(yíng)養(yǎng)、增加食品的強(qiáng)度;(3)利用單細(xì)胞蛋白質(zhì)的蛋白質(zhì)**形成性可用于制造“人造肉”等新食品;(4)SCP還常作為食品添加劑，用以補(bǔ)充蛋白質(zhì)或維生素、礦物質(zhì)等;(5)SCP運(yùn)用于肉制品和焙烤食品的制作中，可保持食品水分、口感和風(fēng)味等;(6)SCP能提高食品的某些物理性能，如意大利烘餅中加入活性酵母可提高餅的延薄性能，酵母濃縮鮮劑蛋白具有顯著的鮮味而***用作食品的增鮮劑。、單細(xì)胞蛋白的生產(chǎn)現(xiàn)狀及前景展望我國(guó)SCP生產(chǎn)始于1922年，1986年4月10日，我國(guó)***個(gè)SCP飼料廠在廣東省江門市建成并試產(chǎn)成功。1987年全國(guó)SCP(酵母)總產(chǎn)量，其中固體酵母達(dá)。北京中藥微生物菌種定向改良工藝服務(wù)</p><p style="text-indent:25px">上海朝瑞生物科技有限公司坐落在上海市松江區(qū)廣富林路697號(hào)昂立大廈2113室，是一家專業(yè)的1.發(fā)布科研技術(shù) 2.發(fā)布應(yīng)用技術(shù) 3.發(fā)布專業(yè)專長(zhǎng) 4.發(fā)布科研成果 5.發(fā)布我的需求 6.發(fā)布篩選檢驗(yàn)檢測(cè)服務(wù) 7.發(fā)布協(xié)同代研發(fā)服務(wù) 8.發(fā)布升級(jí)改造產(chǎn)品服務(wù) 9.發(fā)布實(shí)驗(yàn)室及儀器設(shè)備共享 10.發(fā)布培訓(xùn)基地共享 11.發(fā)布工廠代加工及共享車間 12.發(fā)布科研/項(xiàng)目團(tuán)隊(duì)招聘13.發(fā)布研究生婚戀 14.發(fā)布項(xiàng)目整包服務(wù) 15.發(fā)布資源交換業(yè)務(wù)公司。公司目前擁有5~10人員工，為員工提供廣闊的發(fā)展平臺(tái)與成長(zhǎng)空間，為客戶提供高質(zhì)高效的產(chǎn)品服務(wù)，深受員工與客戶好評(píng)。公司以誠(chéng)信為本，業(yè)務(wù)領(lǐng)域涵蓋[ "科研技術(shù)服務(wù)", "應(yīng)用技術(shù)服務(wù)", "科研成果轉(zhuǎn)化", "科學(xué)產(chǎn)品銷售" ]，我們本著對(duì)客戶負(fù)責(zé)，對(duì)員工負(fù)責(zé)，更是對(duì)公司發(fā)展負(fù)責(zé)的態(tài)度，爭(zhēng)取做到讓每位客戶滿意。公司力求給客戶提供***質(zhì)量服務(wù)，我們相信誠(chéng)實(shí)正直、開拓進(jìn)取地為公司發(fā)展做正確的事情，將為公司和個(gè)人帶來(lái)共同的利益和進(jìn)步。經(jīng)過(guò)幾年的發(fā)展，已成為[ "科研技術(shù)服務(wù)", "應(yīng)用技術(shù)服務(wù)", "科研成果轉(zhuǎn)化", "科學(xué)產(chǎn)品銷售" ]行業(yè)**企業(yè)。</p></p><br 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