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#f30;"></span></p><p><span>產(chǎn)品關(guān)鍵詞：</span>北京毒理學安全性評價檢測分析,毒理學安全性評價</p><p><span>***更新：</span>2020-07-28 09:10:40</p><p><span id="click" >瀏覽次數(shù)：0次</span></p><a rel="nofollow" class="button">聯(lián)系我們</a></div></div><div id="3jvnpwy" class="rightbox"><h3>公司基本資料信息</h3><p style="border:0;"><a rel="nofollow">上海朝瑞生物科技有限公司</a></p><p><span>聯(lián)系人：</span>仲先生</p><p><span>郵箱: </span>scienceladder@163.com</p><p><span>電話: </span>18621867065</p><p><span>傳真: </span>021_</p><p><span>網(wǎng)址: </span></p><p><span>手機: </span>021-54133071</p><p><span>地址: </span>上海市松江區(qū)廣富林路697號昂立大廈2113室</p><p>[當前離線] <a rel="nofollow"> [加為商友] </a><a rel="nofollow"> [發(fā)送信件] </a></p></div></div><div id="odahj3s" class="page-proshow02"><p class="title">詳細說明</p><div id="zol798s" class="box"><p><p> 過體外試驗、動物試驗和人群觀察，發(fā)現(xiàn)和闡明被評價物質(zhì)（食品或與食品有關(guān)的產(chǎn)品）的毒性和潛在的危害，北京毒理學安全性評價檢測分析，以便對人類使用這種食品的安全性作出評價，并為制定預(yù)防措施和衛(wèi)生標準提供理論依據(jù)。毒理學實驗四個階段： </p> <p> 第四階段：慢性毒性實驗：考查少量該品長期對機體的影響，確定比較大無作用量（MNL），一般以壽命較短敏感的動物的一生為一個試驗階段，北京毒理學安全性評價檢測分析，如用大白鼠試驗2年小白鼠試驗1，北京毒理學安全性評價檢測分析.5年。目的：獲得經(jīng)長期接觸受試物后出現(xiàn)的毒性作用以及致*作用資料，從而確定比較大未觀察到有害作用的劑量，為受試物能否應(yīng)用于食品的**終評價提供依據(jù)。試驗項目：將兩年慢性毒性試驗和致*試驗結(jié)合在一個動物試驗中進行。用兩種性別的大鼠和（或）小鼠結(jié)果判定：如慢性毒性試驗所得的比較大無作用劑量（以mg/kg體重計）北京毒理學安全性評價檢測分析</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="北京毒理學安全性評價檢測分析,毒理學安全性評價" src="http://tyunfile.71360.com/UploadFile/shchaorui/637129699844843750/4385430.png"></div><p> 安全毒理學評價編輯鎖定討論本詞條由“科普中國”科學百科詞條編寫與應(yīng)用工作項目審核。通過體外試驗、動物試驗和人群觀察，發(fā)現(xiàn)和闡明被評價物質(zhì)（食品或與食品有關(guān)的產(chǎn)品）的毒性和潛在的危害，以便對人類使用這種食品的安全性作出評價，并為制定預(yù)防措施和衛(wèi)生標準提供理論依據(jù)。中文名食品安全性毒理學評價外文名Foodsafetytoxicologyevaluation目錄1定義2相關(guān)法律法規(guī)3準備工作4選用原則5主要內(nèi)容和程序?（1）***階段急性毒性試驗?（2）第二階段遺傳毒性試驗?（3）第三階段亞慢性毒性試驗?（4）第四階段慢性毒性試驗6應(yīng)用安全毒理學評價定義編輯食品安全性毒理學評價是運用現(xiàn)代毒理學理論，并結(jié)合流行病學調(diào)查分析和闡明食品或食品中的特定物質(zhì)的毒性及其潛在危害，預(yù)測人體接觸后可能對人體健康產(chǎn)生影響的性質(zhì)和強度，提出食用安全風險和預(yù)防措施的一門技術(shù)。[1]安全毒理學評價相關(guān)法律法規(guī)編輯（1）《食品安全性毒理學評價程序》；（2）《農(nóng)藥安全性毒理學評價程序》；（3）《新藥（西藥）毒理學研究指導(dǎo)原則》；（4）《化妝品安全性評價程序和方法》；（5）《食品功能毒理學評價程序和檢驗方法》；。6）《食品毒理學實驗室操作規(guī)范》安全毒理學評價準備工作編輯。北京毒理學安全性評價檢測分析</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="北京毒理學安全性評價檢測分析,毒理學安全性評價" src="http://tyunfile.71360.com/UploadFile/shchaorui/637129699839501954/2931299.png"></div><p> Ⅳ如此三項試驗均為陰性，則可進入亞慢性試驗。3.代謝試驗對于我國創(chuàng)制的化學物質(zhì)，在進行**終評價時，至少應(yīng)進行以下幾項代謝方面的試驗：①胃腸道吸收試驗；②測定血濃度，計算生物半減期和其他動力學指標；③主要***和組織中的分布試驗；④排泄（尿、糞、膽汁）試驗。有條件時，可進一步進行代謝產(chǎn)物的分離、鑒定。對于國際上多數(shù)國家已經(jīng)批準使用和毒性評價資料比較齊全的化學物質(zhì)，可暫不要求進行代謝試驗。對于屬于人體正常成分的物質(zhì)可不必進行代謝研究。安全毒理學評價（3）第三階段亞慢性毒性試驗?zāi)康模涸撾A段的主要目的是觀察受試物以不同劑量水平經(jīng)較長期喂養(yǎng)后，對實驗動物的毒性作用性質(zhì)和靶***，了解受試物對動物繁殖及對子代的發(fā)育毒性，觀察對生長發(fā)育的影響，并初步確定比較大未觀察到有害作用的劑量和致*的可能性，同時為慢性毒性和致*試驗的劑量選擇提供依據(jù)。代謝試驗可以了解受試物在體內(nèi)的吸收、分布和排泄速度以及蓄積性，尋找可能的靶***。為選擇慢性毒性試驗的合適動物種、系提供依據(jù)，了解代謝產(chǎn)物的形成情況。試驗項目：包括4種試驗，90天喂養(yǎng)試驗、繁殖試驗、喂養(yǎng)致畸試驗、傳統(tǒng)致畸實驗用兩種性別大鼠和（或）小鼠。</p><p> 產(chǎn)品類別檢測項目食品（保健食品）食品（保健食品）急性經(jīng)口毒性試驗(限量法)食品（保健食品）細菌回復(fù)突變試驗食品（保健食品）哺乳動物紅細胞微核試驗食品（保健食品）精母細胞染色體畸變試驗食品（保健食品）28天經(jīng)口毒性試驗食品90天經(jīng)口毒性試驗食品致畸試驗化妝品化妝品皮膚刺激性/腐蝕性試驗化妝品急性眼刺激性/腐蝕性試驗化妝品皮膚***反應(yīng)試驗皮膚光毒性試驗化妝品急性經(jīng)皮毒性試驗(限量法)化妝品鼠傷寒沙門氏菌／回復(fù)突變試驗化妝品體內(nèi)哺乳動物細胞微核試驗消毒產(chǎn)品消毒產(chǎn)品多次完整皮膚刺激試驗消毒產(chǎn)品急性經(jīng)口毒性試驗(限量法)消毒產(chǎn)品急性眼刺激試驗消毒產(chǎn)品一次破損皮膚刺激試驗消毒產(chǎn)品一次完整皮膚刺激試驗消毒產(chǎn)品睪丸生殖細胞染色體畸變試驗消毒用品微核試驗消毒產(chǎn)品急性吸入毒性試驗一次使用衛(wèi)生用品一次使用衛(wèi)生用品多次皮膚刺激試驗一次性使用衛(wèi)生用品皮膚***反應(yīng)試驗一次性使用衛(wèi)生用品陰道黏膜刺激試驗危險廢物危險廢物急性經(jīng)口毒性試驗危險廢物急性經(jīng)皮毒性試驗危險廢物急性吸入毒性試驗化學品化學品急性經(jīng)口毒性試驗化學品急性皮膚刺激性/腐蝕性試驗化學品急性吸入毒性試驗化學品急性經(jīng)皮毒性試驗化學品皮膚致敏試驗化學品急性眼刺激性/腐蝕性試。</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="北京毒理學安全性評價檢測分析,毒理學安全性評價" src="http://tyunfile.71360.com/UploadFile/shchaorui/637129699835605469/3930676.png"></div><p> 擴展資料：一、食品安全性毒理學評價實驗項目；***階段：急性毒性試驗，試驗項目：1.用霍恩氏法、機率單位法或寇氏法，測定經(jīng)口半數(shù)致死量（LD50）。如劑量達10克/公斤體重仍不引起動物死亡，則不必測定半數(shù)致死量。2.必要時進行七天喂養(yǎng)試驗。以上兩個項目均分別用兩種性別的小鼠或大鼠。第二階段：蓄積毒性和致突變試驗，試驗項目：1.蓄積系數(shù)法。用兩種性別的大鼠或小鼠，各20只。2.二十天試驗法。用兩種性別的大鼠或小鼠，每個劑量組雌雄各10只。以上兩種方法任選一種。第三階段：亞慢性毒性（包括繁殖、致畸）試驗和代謝試驗，試驗項目：。2.喂養(yǎng)繁殖試驗。3.喂養(yǎng)致畸試驗。4.傳統(tǒng)致畸試驗。第四階段：慢性毒性（包括致*）試驗，試驗項目：可將兩年慢性毒性試驗和致*試驗結(jié)合在一個動物試驗中進行。用兩種性別的大鼠或小鼠。二：食品安全性毒理學評價實驗要求：1、凡屬我國創(chuàng)制的新化學物質(zhì)，一般要求進行四個階段的試驗。特別是對其中化學結(jié)構(gòu)提示有慢性毒性或致*作用可能者，產(chǎn)量大、使用面積廣、攝入機會多者，必需進行全部四個階段的試驗。2、凡屬與已知物質(zhì)（指經(jīng)過安全性評價并允許使用者）的化學結(jié)構(gòu)基本相同的衍生物，則可根據(jù)***、二、三階段試驗的結(jié)果。北京毒理學安全性評價檢測分析</p><p style="text-indent:25px">北京毒理學安全性評價檢測分析</p><p> 過體外試驗、動物試驗和人群觀察，發(fā)現(xiàn)和闡明被評價物質(zhì)（食品或與食品有關(guān)的產(chǎn)品）的毒性和潛在的危害，以便對人類使用這種食品的安全性作出評價，并為制定預(yù)防措施和衛(wèi)生標準提供理論依據(jù)。毒理學實驗四個階段： </p> <p> <p> 第二階段：遺傳毒性試驗，30 天喂養(yǎng)試驗，傳統(tǒng)致畸試驗 </p> <p> 遺傳毒性試驗的組合應(yīng)該考慮原核細胞與真核細胞、體內(nèi)試驗與體外試驗相結(jié)合的原則。從Ames 試驗或V79/HGPRT 基因突變試驗、骨髓細胞微核試驗或哺乳動物骨髓細胞染色體畸變試驗、TK 基因突變試驗或小鼠精子畸形分析（或睪丸染色體畸變分析試驗）中分別各選一項。 </p> 北京毒理學安全性評價檢測分析</p><p style="text-indent:25px">上海朝瑞生物科技有限公司創(chuàng)辦于2003-01-22，是一家服務(wù)型的公司。經(jīng)過多年不斷的歷練探索和創(chuàng)新發(fā)展，公司是一家有限責任公司企業(yè)，以誠信務(wù)實的創(chuàng)業(yè)精神、質(zhì)量高效的管理團隊、精悍的職工隊伍，努力為廣大用戶提供***的產(chǎn)品。公司業(yè)務(wù)涵蓋[ "科研技術(shù)服務(wù)", "應(yīng)用技術(shù)服務(wù)", "科研成果轉(zhuǎn)化", "科學產(chǎn)品銷售" ]，價格合理，品質(zhì)有保證，深受廣大客戶的歡迎。上海朝瑞科技以創(chuàng)造***產(chǎn)品及服務(wù)的理念，打造高指標的服務(wù)，引導(dǎo)行業(yè)的發(fā)展。</p></p><br /><p>文章來源地址: http://www.cdcfah.com/cp/727384.html</p></div></div></div></div></div><div id="tn3nu3v" class="page-right twoColRt"><div id="fuw4x8u" class="box01 margin10 clearfix"><h3><a href="http://www.cdcfah.com/cp/">猜你喜歡</a></h3><div id="s8n3498" class="recomPic likePro"><a href="http://www.cdcfah.com/cp/814588.html"><div><img src="http://tyunfile.71360.com/UpLoadFile/2019/11/1/14/637082168864691056_lgpj_5374157.jpg" alt="福建ZF配件哪家強信息推薦自業(yè)物資供應(yīng)" class="vcenter" 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