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id="ngszb8u" class="content"><p><span>需求數(shù)量：</span>0</p><p><span>價格要求：</span>面議</p><p><span>所在地：</span>上海市</p><p><span>包裝要求：</span><span style="color: #f30;"></span></p><p><span>產(chǎn)品關(guān)鍵詞：</span>江蘇毒代動力毒理學(xué)安全性評價技術(shù)服務(wù),毒理學(xué)安全性評價</p><p><span>***更新：</span>2020-08-02 17:05:38</p><p><span id="click" >瀏覽次數(shù)：0次</span></p><a rel="nofollow" class="button">聯(lián)系我們</a></div></div><div id="w3qc22c" class="rightbox"><h3>公司基本資料信息</h3><p style="border:0;"><a rel="nofollow">上海朝瑞生物科技有限公司</a></p><p><span>聯(lián)系人：</span>仲先生</p><p><span>郵箱: </span>scienceladder@163.com</p><p><span>電話: </span>18621867065</p><p><span>傳真: </span>021_</p><p><span>網(wǎng)址: </span></p><p><span>手機(jī): </span>021-54133071</p><p><span>地址: </span>上海市松江區(qū)廣富林路697號昂立大廈2113室</p><p>[當(dāng)前離線] <a rel="nofollow"> [加為商友] </a><a rel="nofollow"> [發(fā)送信件] </a></p></div></div><div id="imtqxoq" class="page-proshow02"><p class="title">詳細(xì)說明</p><div id="77a3gpl" class="box"><p><p> Ⅳ如此三項試驗均為陰性，則可進(jìn)入亞慢性試驗。3.代謝試驗對于我國創(chuàng)制的化學(xué)物質(zhì)，在進(jìn)行**終評價時，至少應(yīng)進(jìn)行以下幾項代謝方面的試驗：①胃腸道吸收試驗；②測定血濃度，計算生物半減期和其他動力學(xué)指標(biāo)；③主要***和組織中的分布試驗；④排泄（尿、糞、膽汁）試驗。有條件時，可進(jìn)一步進(jìn)行代謝產(chǎn)物的分離、鑒定。對于國際上多數(shù)國家已經(jīng)批準(zhǔn)使用和毒性評價資料比較齊全的化學(xué)物質(zhì)，可暫不要求進(jìn)行代謝試驗。對于屬于人體正常成分的物質(zhì)可不必進(jìn)行代謝研究。安全毒理學(xué)評價（3）第三階段亞慢性毒性試驗?zāi)康模涸撾A段的主要目的是觀察受試物以不同劑量水平經(jīng)較長期喂養(yǎng)后，對實驗動物的毒性作用性質(zhì)和靶***，了解受試物對動物繁殖及對子代的發(fā)育毒性，觀察對生長發(fā)育的影響，并初步確定比較大未觀察到有害作用的劑量和致*的可能性，同時為慢性毒性和致*試驗的劑量選擇提供依據(jù)。代謝試驗可以了解受試物在體內(nèi)的吸收、分布和排泄速度以及蓄積性，尋找可能的靶***。為選擇慢性毒性試驗的合適動物種、系提供依據(jù)，江蘇毒代動力毒理學(xué)安全性評價技術(shù)服務(wù)，了解代謝產(chǎn)物的形成情況。試驗項目：包括4種試驗，90天喂養(yǎng)試驗，江蘇毒代動力毒理學(xué)安全性評價技術(shù)服務(wù)，江蘇毒代動力毒理學(xué)安全性評價技術(shù)服務(wù)、繁殖試驗、喂養(yǎng)致畸試驗、傳統(tǒng)致畸實驗用兩種性別大鼠和（或）小鼠。江蘇毒代動力毒理學(xué)安全性評價技術(shù)服務(wù)</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="江蘇毒代動力毒理學(xué)安全性評價技術(shù)服務(wù),毒理學(xué)安全性評價" src="http://tyunfile.71360.com/UploadFile/shchaorui/637129699848623047/8974668.png"></div><p style="text-indent:25px">2017年中國毒理學(xué)***毒理與安全性評價學(xué)術(shù)大會于2017年05月06-08日在長沙成功召開。此次大會由中國毒理學(xué)會***毒理與安全性評價專業(yè)委員會主辦，湖南省***安全評價研究中心、湖南省新藥藥效與安全評價重點(diǎn)實驗室、***醫(yī)學(xué)科學(xué)院毒物***研究所、國家北京***安全評價研究中心共同承辦。大會主題是“窮新藥研發(fā)洪荒之力，仗安全評價保駕護(hù)航”，在國際上OECD、美國FDA 和我國GLP法規(guī)和相關(guān)安全性評價研究技術(shù)指導(dǎo)原則進(jìn)行修訂的背景下，我國新藥研制重大專項十三五發(fā)展規(guī)劃和十三五國家藥品安全規(guī)劃***實施的前提下和我國新藥審評和監(jiān)管*****起得***進(jìn)展的大好形勢下，旨在為我國***毒理學(xué)工作者就國內(nèi)外GLP規(guī)范修訂與實施***動向、***毒理學(xué)研究的***進(jìn)展和***臨床前安全性評價新思路、新技術(shù)創(chuàng)建一個**學(xué)術(shù)交流平臺。江蘇致畸毒理學(xué)安全性評價檢測分析</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="江蘇毒代動力毒理學(xué)安全性評價技術(shù)服務(wù),毒理學(xué)安全性評價" src="http://tyunfile.71360.com/UploadFile/shchaorui/637129699841435547/3737546.png"></div><p> 安全毒理學(xué)評價編輯鎖定討論本詞條由“科普中國”科學(xué)百科詞條編寫與應(yīng)用工作項目審核。通過體外試驗、動物試驗和人群觀察，發(fā)現(xiàn)和闡明被評價物質(zhì)（食品或與食品有關(guān)的產(chǎn)品）的毒性和潛在的危害，以便對人類使用這種食品的安全性作出評價，并為制定預(yù)防措施和衛(wèi)生標(biāo)準(zhǔn)提供理論依據(jù)。中文名食品安全性毒理學(xué)評價外文名Foodsafetytoxicologyevaluation目錄1定義2相關(guān)法律法規(guī)3準(zhǔn)備工作4選用原則5主要內(nèi)容和程序?（1）***階段急性毒性試驗?（2）第二階段遺傳毒性試驗?（3）第三階段亞慢性毒性試驗?（4）第四階段慢性毒性試驗6應(yīng)用安全毒理學(xué)評價定義編輯食品安全性毒理學(xué)評價是運(yùn)用現(xiàn)代毒理學(xué)理論，并結(jié)合流行病學(xué)調(diào)查分析和闡明食品或食品中的特定物質(zhì)的毒性及其潛在危害，預(yù)測人體接觸后可能對人體健康產(chǎn)生影響的性質(zhì)和強(qiáng)度，提出食用安全風(fēng)險和預(yù)防措施的一門技術(shù)。[1]安全毒理學(xué)評價相關(guān)法律法規(guī)編輯（1）《食品安全性毒理學(xué)評價程序》；（2）《農(nóng)藥安全性毒理學(xué)評價程序》；（3）《新藥（西藥）毒理學(xué)研究指導(dǎo)原則》；（4）《化妝品安全性評價程序和方法》；（5）《食品功能毒理學(xué)評價程序和檢驗方法》；。6）《食品毒理學(xué)實驗室操作規(guī)范》安全毒理學(xué)評價準(zhǔn)備工作編輯。</p><p style="text-indent:25px">【題名】蝦青素的毒理學(xué)安全性評價【作者】劉敏胡嘉想秦光和景簫王偉【機(jī) 構(gòu)】云南省疾病預(yù)防控制中心,云南昆明650022【刊名】毒理學(xué)雜志, 2008(3): 244-246【關(guān)鍵詞】蝦青素 LD50 遺傳毒性 Ames試驗精子畸形微核【文摘】蝦青素（Astaxanthin）是一種天然的類胡蘿卜素，它的分子式為C40H52O4與β-胡蘿卜素（Beta-carotene）相似，分子式為C40H52。在一些體外試驗中，蝦青素具有較β-胡蘿卜素更強(qiáng)的抗氧化性，同時它也是一種天然色素，作為飼料添加劑應(yīng)用于畜牧飼養(yǎng)業(yè)和水產(chǎn)養(yǎng)殖業(yè)。另外，有研究表明，蝦青素在動物實驗?zāi)Ｐ椭杏?**的作用。但迄今為止，未見有關(guān)蝦青素毒理學(xué)安全性的研究報道。本研究對蝦青素進(jìn)行了急性毒性和遺傳毒性試驗，旨在評估其食用安全性，為蝦青素在食品和在養(yǎng)殖業(yè)中的應(yīng)用提供實驗依據(jù)。</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="江蘇毒代動力毒理學(xué)安全性評價技術(shù)服務(wù),毒理學(xué)安全性評價" src="http://tyunfile.71360.com/UploadFile/shchaorui/637129699835605469/3930676.png"></div><p> 產(chǎn)品類別檢測項目食品（保健食品）食品（保健食品）急性經(jīng)口毒性試驗(限量法)食品（保健食品）細(xì)菌回復(fù)突變試驗食品（保健食品）哺乳動物紅細(xì)胞微核試驗食品（保健食品）精母細(xì)胞染色體畸變試驗食品（保健食品）28天經(jīng)口毒性試驗食品90天經(jīng)口毒性試驗食品致畸試驗化妝品化妝品皮膚刺激性/腐蝕性試驗化妝品急性眼刺激性/腐蝕性試驗化妝品皮膚***反應(yīng)試驗皮膚光毒性試驗化妝品急性經(jīng)皮毒性試驗(限量法)化妝品鼠傷寒沙門氏菌／回復(fù)突變試驗化妝品體內(nèi)哺乳動物細(xì)胞微核試驗消毒產(chǎn)品消毒產(chǎn)品多次完整皮膚刺激試驗消毒產(chǎn)品急性經(jīng)口毒性試驗(限量法)消毒產(chǎn)品急性眼刺激試驗消毒產(chǎn)品一次破損皮膚刺激試驗消毒產(chǎn)品一次完整皮膚刺激試驗消毒產(chǎn)品睪丸生殖細(xì)胞染色體畸變試驗消毒用品微核試驗消毒產(chǎn)品急性吸入毒性試驗一次使用衛(wèi)生用品一次使用衛(wèi)生用品多次皮膚刺激試驗一次性使用衛(wèi)生用品皮膚***反應(yīng)試驗一次性使用衛(wèi)生用品陰道黏膜刺激試驗危險廢物危險廢物急性經(jīng)口毒性試驗危險廢物急性經(jīng)皮毒性試驗危險廢物急性吸入毒性試驗化學(xué)品化學(xué)品急性經(jīng)口毒性試驗化學(xué)品急性皮膚刺激性/腐蝕性試驗化學(xué)品急性吸入毒性試驗化學(xué)品急性經(jīng)皮毒性試驗化學(xué)品皮膚致敏試驗化學(xué)品急性眼刺激性/腐蝕性試。上海毒代動力毒理學(xué)安全性評價</p><p style="text-indent:25px">江蘇毒代動力毒理學(xué)安全性評價技術(shù)服務(wù)</p><p style="text-indent:25px">本次能力驗證計劃負(fù)責(zé)人于洲副主任介紹了“食品毒理學(xué)安全性評價之毒***理學(xué)檢查”概況和整體實施方案，對能力驗證工作整體安排進(jìn)行了說明,并重點(diǎn)圍繞方案設(shè)計、項目參加單位情況、考核樣本制備及發(fā)放、項目**組、保密性、評價原則和考核結(jié)果等分別進(jìn)行了詳細(xì)的解讀。能力驗證計劃技術(shù)**評估中心汪會玲副主任技師從病變描述和病變診斷等方面，對本次能力驗證考核病理樣本進(jìn)行了詳細(xì)解讀，對考核中參與單位集中出現(xiàn)的問題進(jìn)行了講解，并現(xiàn)場回答了部分參會者的提問。本次總結(jié)會，評估中心還針對考核中出現(xiàn)的病理描述和診斷不統(tǒng)一，專業(yè)術(shù)語使用不準(zhǔn)確等問題，特別邀請了中國毒理學(xué)會毒***理專業(yè)委員會王和枚研究員和呂**研究員兩位*****，分別就“如何做好毒***理診斷與報告”和“組織病理學(xué)同行評議及病理工作組”對參會人員進(jìn)行了培訓(xùn)，從而進(jìn)一步夯實了病理學(xué)檢查人員的技術(shù)基礎(chǔ)，提高了對毒***理學(xué)工作的理解。江蘇毒代動力毒理學(xué)安全性評價技術(shù)服務(wù)</p><p style="text-indent:25px">上海朝瑞生物科技有限公司位于上海市，創(chuàng)立于2003-01-22。公司業(yè)務(wù)涵蓋[ "科研技術(shù)服務(wù)", "應(yīng)用技術(shù)服務(wù)", "科研成果轉(zhuǎn)化", "科學(xué)產(chǎn)品銷售" ]等，價格合理，品質(zhì)有保證。公司將不斷增強(qiáng)企業(yè)核心競爭力，努力學(xué)習(xí)行業(yè)先進(jìn)知識，遵守行業(yè)規(guī)范，植根于化工行業(yè)的發(fā)展。公司憑借深厚技術(shù)支持，年營業(yè)額度達(dá)到2000-3000萬元，并與多家行業(yè)**公司建立了緊密的合作關(guān)系。</p></p><br /><p>文章來源地址: 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