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#f30;"></span></p><p><span>產(chǎn)品關(guān)鍵詞：</span>天津免疫原性毒理學(xué)安全性評(píng)價(jià)檢測(cè)分析,毒理學(xué)安全性評(píng)價(jià)</p><p><span>***更新：</span>2020-08-05 06:17:22</p><p><span id="click" >瀏覽次數(shù)：0次</span></p><a rel="nofollow" class="button">聯(lián)系我們</a></div></div><div id="nm39ypm" class="rightbox"><h3>公司基本資料信息</h3><p style="border:0;"><a rel="nofollow">上海朝瑞生物科技有限公司</a></p><p><span>聯(lián)系人：</span>仲先生</p><p><span>郵箱: </span>scienceladder@163.com</p><p><span>電話(huà): </span>18621867065</p><p><span>傳真: </span>021_</p><p><span>網(wǎng)址: </span></p><p><span>手機(jī): </span>021-54133071</p><p><span>地址: </span>上海市松江區(qū)廣富林路697號(hào)昂立大廈2113室</p><p>[當(dāng)前離線(xiàn)] <a rel="nofollow"> [加為商友] </a><a rel="nofollow"> [發(fā)送信件] </a></p></div></div><div id="azbi8of" class="page-proshow02"><p class="title">詳細(xì)說(shuō)明</p><div id="t3qbdk2" class="box"><p><p> 通過(guò)體外試驗(yàn)、動(dòng)物試驗(yàn)和人群觀(guān)察，發(fā)現(xiàn)和闡明被評(píng)價(jià)物質(zhì)（食品或與食品有關(guān)的產(chǎn)品）的毒性和潛在的危害，以便對(duì)人類(lèi)使用這種食品的安全性作出評(píng)價(jià)，并為制定預(yù)防措施和衛(wèi)生標(biāo)準(zhǔn)提供理論依據(jù)，天津免疫原性毒理學(xué)安全性評(píng)價(jià)檢測(cè)分析。毒理學(xué)實(shí)驗(yàn)四個(gè)階段： </p> <p> ***階段：急性毒性試驗(yàn)：它是一次性投較大劑量后觀(guān)察動(dòng)物的變化，觀(guān)察期大約為1周，從而判定動(dòng)物的致死量（LD）和半致死量（LD50），天津免疫原性毒理學(xué)安全性評(píng)價(jià)檢測(cè)分析。半致死量是指實(shí)驗(yàn)動(dòng)物死亡一半的投藥量。如果投藥量大于5000mg/kg，天津免疫原性毒理學(xué)安全性評(píng)價(jià)檢測(cè)分析，無(wú)死亡，可認(rèn)為該品毒性較低，無(wú)需做致死量精確測(cè)定。天津免疫原性毒理學(xué)安全性評(píng)價(jià)檢測(cè)分析</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="天津免疫原性毒理學(xué)安全性評(píng)價(jià)檢測(cè)分析,毒理學(xué)安全性評(píng)價(jià)" src="http://tyunfile.71360.com/UploadFile/shchaorui/637129699841435547/3737546.png"></div><p style="text-indent:25px">食品安全性毒理學(xué)評(píng)價(jià)是運(yùn)用現(xiàn)代毒理學(xué)理論，并結(jié)合流行病學(xué)調(diào)查分析和闡明食品或食品中的特定物質(zhì)的毒性及其潛在危害，預(yù)測(cè)人體接觸后可能對(duì)人體健康產(chǎn)生影響的性質(zhì)和強(qiáng)度，提出食用安全風(fēng)險(xiǎn)和預(yù)防措施的一門(mén)技術(shù)。 [1] 相關(guān)法律法規(guī)編輯（1）《食品安全性毒理學(xué)評(píng)價(jià)程序》；（2）《農(nóng)藥安全性毒理學(xué)評(píng)價(jià)程序》；（3）《新藥（西藥）毒理學(xué)研究指導(dǎo)原則》；（4）《化妝品安全性評(píng)價(jià)程序和方法》；（5）《食品功能毒理學(xué)評(píng)價(jià)程序和檢驗(yàn)方法》；（6）《食品毒理學(xué)實(shí)驗(yàn)室操作規(guī)范》。上海免疫原性毒理學(xué)安全性評(píng)價(jià)</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="天津免疫原性毒理學(xué)安全性評(píng)價(jià)檢測(cè)分析,毒理學(xué)安全性評(píng)價(jià)" src="http://tyunfile.71360.com/UploadFile/shchaorui/637129699848623047/8974668.png"></div><p> 1）收集化學(xué)物質(zhì)有關(guān)的基本資料；（2）了解化學(xué)物質(zhì)的使用情況；（3）選用人類(lèi)實(shí)際接觸和應(yīng)用的產(chǎn)品形式進(jìn)行實(shí)驗(yàn)；（4）選擇實(shí)驗(yàn)動(dòng)物的要求。安全毒理學(xué)評(píng)價(jià)選用原則編輯（1）凡屬我國(guó)創(chuàng)新的受試物一般要求進(jìn)行四個(gè)階段的試驗(yàn)，特別是對(duì)其中化學(xué)結(jié)構(gòu)提示有慢性毒性、遺傳毒性或致*性可能者或產(chǎn)量大、使用范圍廣、攝入機(jī)會(huì)者多，必須進(jìn)行全部四個(gè)階段的毒性試驗(yàn)。（2）凡屬與已知物質(zhì)（指經(jīng)過(guò)安全性評(píng)價(jià)并允許使用者）的化學(xué)結(jié)構(gòu)基本相同的衍生物或類(lèi)似物，則根據(jù)一、二、三階段毒性試驗(yàn)結(jié)果判斷是否需要進(jìn)行第四階段試驗(yàn)。（3）凡屬已知的化學(xué)物質(zhì)，世界衛(wèi)生組織對(duì)其已公布每人每日允許攝入量（ADI）的，同時(shí)申請(qǐng)單位又有資料證明我國(guó)產(chǎn)品的質(zhì)量規(guī)格與國(guó)外產(chǎn)品一致，則可先進(jìn)行***、二階段試驗(yàn)。如果產(chǎn)品質(zhì)量或者試驗(yàn)結(jié)果與國(guó)外資料一致，一般不要求進(jìn)一步的毒性試驗(yàn)，否則應(yīng)進(jìn)行第三階段試驗(yàn)。（4）農(nóng)藥、食品添加劑、食品新資源和新資源食品、輻照食品、食品工具以及設(shè)備用清洗消毒劑的安全性毒理學(xué)評(píng)價(jià)試驗(yàn)選擇應(yīng)分別符合規(guī)定要求。安全毒理學(xué)評(píng)價(jià)主要內(nèi)容和程序編輯毒理學(xué)試驗(yàn)分為4個(gè)階段：安全毒理學(xué)評(píng)價(jià)（1）***階段急性毒性試驗(yàn)?zāi)康模罕驹囼?yàn)測(cè)定LD50。</p><p style="text-indent:25px">黃素咀嚼片作為功能性食品食用的毒理學(xué)安全性。方法:按照我國(guó)衛(wèi)生部《食品安全毒理學(xué)評(píng)價(jià)程序和檢驗(yàn)方法規(guī)范》進(jìn)行急性毒性試驗(yàn)、遺傳毒性試驗(yàn)(Ames試驗(yàn)、小鼠骨髓細(xì)胞微核試驗(yàn)、小鼠精子畸形試驗(yàn))和30 d喂養(yǎng)試驗(yàn)進(jìn)行毒理學(xué)研究。結(jié)果:葉黃素咀嚼片對(duì)兩種性別的ICR小鼠急性經(jīng)口比較大耐受劑量>20.0g/kgbw,按照急性毒性分級(jí)標(biāo)準(zhǔn)規(guī)定,該受試物屬無(wú)毒級(jí);遺傳毒性試驗(yàn)(Ames試驗(yàn)、骨髓細(xì)胞微核試驗(yàn)、小鼠精子畸形試驗(yàn))均為陰性;30d喂養(yǎng)試驗(yàn)表明,該受試物在0.19、0.38、0.75g/kgbw(分別相當(dāng)于推薦人群日攝入量的25、50、100倍)劑量時(shí),對(duì)SD大鼠的臨床檢查、血液學(xué)、血生化學(xué)和臟器重量和系數(shù)以及病理組織形態(tài)等指標(biāo)均無(wú)明顯不良影響。結(jié)論:葉黃素咀嚼片具有較好的食用安全性。</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="天津免疫原性毒理學(xué)安全性評(píng)價(jià)檢測(cè)分析,毒理學(xué)安全性評(píng)價(jià)" src="http://tyunfile.71360.com/UploadFile/shchaorui/637129699845576172/4944147.png"></div><p> 過(guò)體外試驗(yàn)、動(dòng)物試驗(yàn)和人群觀(guān)察，發(fā)現(xiàn)和闡明被評(píng)價(jià)物質(zhì)（食品或與食品有關(guān)的產(chǎn)品）的毒性和潛在的危害，以便對(duì)人類(lèi)使用這種食品的安全性作出評(píng)價(jià)，并為制定預(yù)防措施和衛(wèi)生標(biāo)準(zhǔn)提供理論依據(jù)。毒理學(xué)實(shí)驗(yàn)四個(gè)階段： </p> <p> <p> 第二階段：遺傳毒性試驗(yàn)，30 天喂養(yǎng)試驗(yàn)，傳統(tǒng)致畸試驗(yàn) </p> <p> 遺傳毒性試驗(yàn)的組合應(yīng)該考慮原核細(xì)胞與真核細(xì)胞、體內(nèi)試驗(yàn)與體外試驗(yàn)相結(jié)合的原則。從Ames 試驗(yàn)或V79/HGPRT 基因突變?cè)囼?yàn)、骨髓細(xì)胞微核試驗(yàn)或哺乳動(dòng)物骨髓細(xì)胞染色體畸變?cè)囼?yàn)、TK 基因突變?cè)囼?yàn)或小鼠精子畸形分析（或睪丸染色體畸變分析試驗(yàn)）中分別各選一項(xiàng)。 </p> 天津免疫原性毒理學(xué)安全性評(píng)價(jià)檢測(cè)分析</p><p style="text-indent:25px">天津免疫原性毒理學(xué)安全性評(píng)價(jià)檢測(cè)分析</p><p> 產(chǎn)品類(lèi)別檢測(cè)項(xiàng)目食品（保健食品）食品（保健食品）急性經(jīng)口毒性試驗(yàn)(限量法)食品（保健食品）細(xì)菌回復(fù)突變?cè)囼?yàn)食品（保健食品）哺乳動(dòng)物紅細(xì)胞微核試驗(yàn)食品（保健食品）精母細(xì)胞染色體畸變?cè)囼?yàn)食品（保健食品）28天經(jīng)口毒性試驗(yàn)食品90天經(jīng)口毒性試驗(yàn)食品致畸試驗(yàn)化妝品化妝品皮膚刺激性/腐蝕性試驗(yàn)化妝品急性眼刺激性/腐蝕性試驗(yàn)化妝品皮膚***反應(yīng)試驗(yàn)皮膚光毒性試驗(yàn)化妝品急性經(jīng)皮毒性試驗(yàn)(限量法)化妝品鼠傷寒沙門(mén)氏菌／回復(fù)突變?cè)囼?yàn)化妝品體內(nèi)哺乳動(dòng)物細(xì)胞微核試驗(yàn)消毒產(chǎn)品消毒產(chǎn)品多次完整皮膚刺激試驗(yàn)消毒產(chǎn)品急性經(jīng)口毒性試驗(yàn)(限量法)消毒產(chǎn)品急性眼刺激試驗(yàn)消毒產(chǎn)品一次破損皮膚刺激試驗(yàn)消毒產(chǎn)品一次完整皮膚刺激試驗(yàn)消毒產(chǎn)品睪丸生殖細(xì)胞染色體畸變?cè)囼?yàn)消毒用品微核試驗(yàn)消毒產(chǎn)品急性吸入毒性試驗(yàn)一次使用衛(wèi)生用品一次使用衛(wèi)生用品多次皮膚刺激試驗(yàn)一次性使用衛(wèi)生用品皮膚***反應(yīng)試驗(yàn)一次性使用衛(wèi)生用品陰道黏膜刺激試驗(yàn)危險(xiǎn)廢物危險(xiǎn)廢物急性經(jīng)口毒性試驗(yàn)危險(xiǎn)廢物急性經(jīng)皮毒性試驗(yàn)危險(xiǎn)廢物急性吸入毒性試驗(yàn)化學(xué)品化學(xué)品急性經(jīng)口毒性試驗(yàn)化學(xué)品急性皮膚刺激性/腐蝕性試驗(yàn)化學(xué)品急性吸入毒性試驗(yàn)化學(xué)品急性經(jīng)皮毒性試驗(yàn)化學(xué)品皮膚致敏試驗(yàn)化學(xué)品急性眼刺激性/腐蝕性試。天津免疫原性毒理學(xué)安全性評(píng)價(jià)檢測(cè)分析</p><p style="text-indent:25px">上海朝瑞生物科技有限公司位于上海市，注冊(cè)資本700-1000萬(wàn)元，旗下?lián)碛?~10人***專(zhuān)業(yè)的員工。zrbiorise,SPRICELL,scienceladde是上海朝瑞生物科技有限公司的主營(yíng)品牌，是專(zhuān)業(yè)的1.發(fā)布科研技術(shù) 2.發(fā)布應(yīng)用技術(shù) 3.發(fā)布專(zhuān)業(yè)專(zhuān)長(zhǎng) 4.發(fā)布科研成果 5.發(fā)布我的需求 6.發(fā)布篩選檢驗(yàn)檢測(cè)服務(wù) 7.發(fā)布協(xié)同代研發(fā)服務(wù) 8.發(fā)布升級(jí)改造產(chǎn)品服務(wù) 9.發(fā)布實(shí)驗(yàn)室及儀器設(shè)備共享 10.發(fā)布培訓(xùn)基地共享 11.發(fā)布工廠(chǎng)代加工及共享車(chē)間 12.發(fā)布科研/項(xiàng)目團(tuán)隊(duì)招聘13.發(fā)布研究生婚戀 14.發(fā)布項(xiàng)目整包服務(wù) 15.發(fā)布資源交換業(yè)務(wù)公司，擁有自己**的技術(shù)體系。公司堅(jiān)持以客戶(hù)為中心、1.發(fā)布科研技術(shù) 2.發(fā)布應(yīng)用技術(shù) 3.發(fā)布專(zhuān)業(yè)專(zhuān)長(zhǎng) 4.發(fā)布科研成果 5.發(fā)布我的需求 6.發(fā)布篩選檢驗(yàn)檢測(cè)服務(wù) 7.發(fā)布協(xié)同代研發(fā)服務(wù) 8.發(fā)布升級(jí)改造產(chǎn)品服務(wù) 9.發(fā)布實(shí)驗(yàn)室及儀器設(shè)備共享 10.發(fā)布培訓(xùn)基地共享 11.發(fā)布工廠(chǎng)代加工及共享車(chē)間 12.發(fā)布科研/項(xiàng)目團(tuán)隊(duì)招聘13.發(fā)布研究生婚戀 14.發(fā)布項(xiàng)目整包服務(wù) 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