江蘇重組Claudin18.2蛋白哪家好 **** 上海朝瑞生物科技供應(yīng)-b2b網(wǎng)站_b2b電子商務(wù)平臺(tái)【買產(chǎn)品】-上?？谄蚴称酚邢薰?/title><meta name="description" content="Claudins家族蛋白在**中的表達(dá)及其研究現(xiàn)狀緊密連接是細(xì)胞黏附形式的一種，主要存在于上皮細(xì)胞、內(nèi)皮細(xì)胞間的連接復(fù)合體中。它可維持機(jī)體內(nèi)環(huán)境的穩(wěn)定，保持上皮細(xì)胞的極性，影響細(xì)胞的運(yùn)動(dòng)、增殖、分化，調(diào)節(jié)細(xì)胞功能的發(fā)揮。緊密連接分子由Occ"><meta name="keywords" content="江蘇重組Claudin18.2蛋白哪家好,Claudin18.2蛋白"><link rel="canonical" href="http://www.cdcfah.com/"/><meta name="applicable-device" content="pc"><link rel="shortcut icon" href="/static/new_net_01/images/favicon.ico"><link rel="stylesheet" href="/static/new_net_01/css/slick.css" /><link rel="stylesheet" href="/static/new_net_01/css/addnew.css"><link rel="stylesheet" href="/static/new_net_01/css/sidenav.css"><link rel="stylesheet" href="/static/new_net_01/css/style.css" /><link rel="stylesheet" href="/static/new_net_01/css/tab.css"><link rel="stylesheet" href="/static/new_net_01/css/404.css"> <meta 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上海朝瑞生物科技供應(yīng)</p><div id="ynpmoqm" class="leftbox clearfix"><h1>江蘇重組Claudin18.2蛋白哪家好 **** 上海朝瑞生物科技供應(yīng)</h1><div id="qa3wt3t" class="proBig"><div id="wqsp8uf" class="bigimg"><div><p class="pic"><img src="http://tyunfile.71360.com/UploadFile/shchaorui/637123969976787109/5241411.png" class="vcenter" onerror="javascript:this.src='/static/new_net_01/images/nopic.jpg';"></p></div></div><div id="q8vx9q2" class="smallimg"><div><p class="pic"><img src="http://tyunfile.71360.com/UploadFile/shchaorui/637123969976787109/5241411.png" class="vcenter" onerror="javascript:this.src='/static/new_net_01/images/nopic.jpg';"></p></div></div></div><div id="88duetl" class="content"><p><span>需求數(shù)量：</span>0</p><p><span>價(jià)格要求：</span>面議</p><p><span>所在地：</span>上海市</p><p><span>包裝要求：</span><span style="color: #f30;"></span></p><p><span>產(chǎn)品關(guān)鍵詞：</span>江蘇重組Claudin18.2蛋白哪家好,Claudin18.2蛋白</p><p><span>***更新：</span>2020-08-22 05:17:20</p><p><span id="click" >瀏覽次數(shù)：0次</span></p><a rel="nofollow" class="button">聯(lián)系我們</a></div></div><div id="zoldc3n" class="rightbox"><h3>公司基本資料信息</h3><p style="border:0;"><a rel="nofollow">上海朝瑞生物科技有限公司</a></p><p><span>聯(lián)系人：</span>仲先生</p><p><span>郵箱: </span>scienceladder@163.com</p><p><span>電話: </span>18621867065</p><p><span>傳真: </span>021_</p><p><span>網(wǎng)址: </span></p><p><span>手機(jī): </span>021-54133071</p><p><span>地址: </span>上海市松江區(qū)廣富林路697號(hào)昂立大廈2113室</p><p>[當(dāng)前離線] <a rel="nofollow"> [加為商友] </a><a rel="nofollow"> [發(fā)送信件] </a></p></div></div><div id="fuwd8ji" class="page-proshow02"><p class="title">詳細(xì)說明</p><div id="dc8rtcy" class="box"><p><p> Claudins家族蛋白在**中的表達(dá)及其研究現(xiàn)狀 </p> <p> 緊密連接是細(xì)胞黏附形式的一種，主要存在于上皮細(xì)胞、內(nèi)皮細(xì)胞間的連接復(fù)合體中。它可維持機(jī)體內(nèi)環(huán)境的穩(wěn)定，保持上皮細(xì)胞的極性，影響細(xì)胞的運(yùn)動(dòng)、增殖、分化，調(diào)節(jié)細(xì)胞功能的發(fā)揮。緊密連接分子由Occludin， Claudins 和連接黏附分子(Junctional adhesion molecules, JAMs) 3種完整的膜蛋白和閉合小環(huán)蛋白(ZO-l， ZO-2和ZO-3)等外周胞漿蛋白組成，江蘇重組Claudin18.2蛋白哪家好，江蘇重組Claudin18.2蛋白哪家好，但對(duì)于它們的功能及其調(diào)節(jié)目前研究尚少。近年已證實(shí)Claudin蛋白是構(gòu)成緊密連接的骨架蛋白，其異常表達(dá)可導(dǎo)致上皮細(xì)胞，江蘇重組Claudin18.2蛋白哪家好、內(nèi)皮細(xì)胞結(jié)構(gòu)破壞、功能受損，可能在多種疾病的發(fā)病過程中起重要作用。到目前為止，已發(fā)現(xiàn)Claudin基因家族包括24個(gè)成員，其序列的一致性為12.5%-69.7%，該結(jié)果表明它們?cè)谶M(jìn)化上呈功能高度保守性。江蘇重組Claudin18.2蛋白哪家好</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="江蘇重組Claudin18.2蛋白哪家好,Claudin18.2蛋白" src="http://tyunfile.71360.com/UploadFile/shchaorui/637123969976787109/5241411.png"></div><p> 靶點(diǎn)介紹CLDN18屬于Claudins蛋白家族成員，Claudin蛋白由ShoichiroTsukita及其同事在1998年發(fā)現(xiàn)。在人體內(nèi)由CLDN18基因編碼，該蛋白表達(dá)在上皮上。上皮細(xì)胞是位于皮膚或腔道表層的細(xì)胞，主要功能是作為物理和化學(xué)屏障，上皮細(xì)胞間連接**主要的連接是緊密連接。Claudin是構(gòu)成細(xì)胞緊密連接的重要分子，緊密連接決定了上皮細(xì)胞的滲透性，也起到阻擋細(xì)胞膜表面蛋白和脂質(zhì)擴(kuò)散的作用1。圖1小腸上皮細(xì)胞的三種連接方式：緊密連接、橋粒和間隙連接2通過形態(tài)學(xué)研究，預(yù)測(cè)Claudin蛋白存在于所有的脊椎動(dòng)物中和背囊動(dòng)物中。對(duì)于大部分物種*有幾種Claudin蛋白，哺乳動(dòng)物中有27中Claudin基因，并不是這些基因存在于一種物種中，例如，人有26個(gè)Claudin基因，唯獨(dú)缺少CLDN-13基因。CLDN18基因及蛋白結(jié)構(gòu)特征：人的CLDN18基因具有兩個(gè)不同的1號(hào)外顯子，轉(zhuǎn)錄后經(jīng)過可變剪接**終生成*在N端具有不同序列的兩個(gè)蛋白亞型，如圖2所示。，均具有四個(gè)跨膜結(jié)構(gòu)域，NH2端和COOH端位于胞內(nèi)，具有兩個(gè)胞外環(huán)（ExtracellularLoops：ECL1，ECL2）。，如圖2所示。鑒于CLDN18的膜蛋白特性，，篩選針對(duì)。圖2；；，方框分別表示(E)和(E)特異的***外顯子4；，藍(lán)色框表示***個(gè)胞外環(huán)。江蘇重組Claudin18.2蛋白哪家好</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="江蘇重組Claudin18.2蛋白哪家好,Claudin18.2蛋白" src="http://tyunfile.71360.com/UploadFile/shchaorui/637123969947470703/6434202.png"></div><p> claudin-7基因是胃*中經(jīng)常表達(dá)上調(diào)的基因，使用免疫組化方法發(fā)現(xiàn)，小鼠和人類胃黏膜腺體不典型增生時(shí)，常過度表達(dá)clandin-7，而其周圍正常胃黏膜組織卻不表達(dá)。其在腸化、不典型增生和胃*中表達(dá)陽性率分別為30%、80%和70%，并且多在腸型胃*中表達(dá)。Park等通過免疫組化和Westemblot方法發(fā)現(xiàn)，claudin-7更常表達(dá)于腸化、腺瘤和胃*中，而在47%的正常胃黏膜中不表達(dá)，只有l(wèi)P/。的腸型胃*不表達(dá)claudin-7，而彌散型胃*不表達(dá)率達(dá)到41%。所以，研究人員認(rèn)為claudin-7的表達(dá)參與了胃*早期發(fā)展過程。Lkmi等在研究食道鱗*中發(fā)現(xiàn)，claudin-7的功能異常導(dǎo)致E-cadherin表達(dá)減少，從而增加了食道鱗*的侵襲性。用siRNA方法使食道鱗*細(xì)胞株中claudin-7失活，導(dǎo)致E-cadherin表達(dá)減少。由于在彌散型胃*中E-cadherin和claudin-7都較正常組織和腸型胃*明顯減少，推測(cè)在胃*中可能也存在這種機(jī)制。 </p><p> 對(duì)照組：vsIMAB362組：）在IMAB362組中略微常見。與單純化療相比較，IMAB362組的嚴(yán)重不良反應(yīng)率并未增加。下一步計(jì)劃一項(xiàng)III期研究計(jì)劃在2017年上半年開展。研究人員還計(jì)劃在胰腺*患者中開展一項(xiàng)IMAB362的II期研究。ASCO觀點(diǎn)：“很令人興奮的看到免疫***可以提高胃*的生存期。Claudin，而且這種***可能適用于一半的胃*患者，”SmithaKrishnamurthi說（ASCO胃***，6月5日新聞發(fā)布會(huì)主持人）。摘要簡(jiǎn)介：（）是一種在多種**（包括胃*和胃食管交界腺*）中表達(dá)的緊密連接蛋白質(zhì)。IMAB362是一種嵌合型單克隆抗體，可以通過免疫效應(yīng)機(jī)制***介導(dǎo)特異性CLDN。IMAB362已經(jīng)證明了其單藥活性，在預(yù)***胃*患者中安全且可耐受。方法：晚期/復(fù)發(fā)性胃*和GEJ腺*通過IHC對(duì)CLDN（經(jīng)驗(yàn)證的Kit）表達(dá)進(jìn)行集中評(píng)估。符合條件的患者在≥40%的**細(xì)胞中CLDN≥2，ECOGPS評(píng)分為0-1，應(yīng)用過曲妥珠單抗不符合納入條件?；颊甙凑?:1隨機(jī)接受**EOX（表柔比星50mg/m2+奧沙利鉑130mg/m2d1，+卡培他濱625mg/m2bid，d1-d21；qd22）聯(lián)合或不聯(lián)合IMAB362（負(fù)荷劑量800mg/m2，然后600mg/m2d1，qd21）。該項(xiàng)研究通過一個(gè)探索組3（n=85）進(jìn)行擴(kuò)展以研究IMAB362（1000mg/m2）聯(lián)合EOX的高劑量。</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="江蘇重組Claudin18.2蛋白哪家好,Claudin18.2蛋白" src="http://tyunfile.71360.com/UploadFile/shchaorui/637123969978212891/5022427.png"></div><p> 現(xiàn)實(shí)生活中，8胃*、胰腺*、食道*以及轉(zhuǎn)移和未轉(zhuǎn)移卵巢*免疫zhilao中存在著手術(shù)切除復(fù)發(fā)率高、化療和放療毒副作用強(qiáng)以及單抗zhilao費(fèi)用高的問題，迫切需要新的技術(shù)產(chǎn)生，而通過對(duì)claudins在胃*中異常分布和表達(dá)的研究，人們能更好得理解胃*的發(fā)展機(jī)制，從而有利于胃*的診斷和zhilao。Claudins在胃*前病變、胃*各期和各型中的表達(dá)的研究是近年熱點(diǎn)，其中claudin-4、claudin-7和ctaudin-18研究較多。Claudin-4定位在人類染色體7ql1。Lee等用免疫組化法研究發(fā)現(xiàn)E-cadherin和claudin-4在69n/。的胃*中均表達(dá)減少，且更常見于彌散型胃*和分化低的胃*，認(rèn)為兩種蛋白作用類似，可能與胃腺體結(jié)構(gòu)的破壞和腺體細(xì)胞的分化喪失有關(guān)。Resnick等研究遠(yuǎn)端胃*患者通過COX多變量分析，發(fā)現(xiàn)**度claudin-4的表達(dá)與胃*患者生存期明顯下降有關(guān)。此外，Cunningham等。通過免疫組化方法發(fā)現(xiàn)claudin-4在36例腸化和14例不典型增生患者中均完全有表達(dá)，在98%胃*原位組織和全部的轉(zhuǎn)移*組織中也有表達(dá)，而*有15%的正常胃黏膜組織表達(dá)claudin-4，說明claudin-4在胃*早期的致*過程中也起了重要作用。江蘇重組Claudin18.2蛋白哪家好</p><p style="text-indent:25px">江蘇重組Claudin18.2蛋白哪家好</p><p style="text-indent:25px"> 胃*在全球**死亡中位列第三，是一種難治性**，可選擇的靶向yaowu較少，靶向zhiliao的療效也欠佳，而且每年約有100萬病例被確診。盡管外科手術(shù)和新化療方案均取得了很大的進(jìn)步，但是5年生存率大約只有5％-20％，晚期胃*患者的中位總生存期(OS)約為10個(gè)月。因此，尋找更有效的方法來延長胃*患者的生命迫在眉睫。Claudin18.2（CLDN18.2）是一種胃特異性膜蛋白，被認(rèn)為是胃*和其他**類型的潛在zhiliao靶點(diǎn)，此靶點(diǎn)的發(fā)現(xiàn)也為胃*的zhiliao提供了一種新的選擇。江蘇重組Claudin18.2蛋白哪家好</p><p style="text-indent:25px">上海朝瑞生物科技有限公司屬于化工的高新企業(yè)，技術(shù)力量雄厚。公司是一家有限責(zé)任公司企業(yè)，以誠信務(wù)實(shí)的創(chuàng)業(yè)精神、質(zhì)量高速的管理團(tuán)隊(duì)、精悍的職工隊(duì)伍，努力為廣大用戶提供***的產(chǎn)品。公司始終堅(jiān)持客戶需求優(yōu)先的原則，致力于提供高質(zhì)量的[ "科研技術(shù)服務(wù)", "應(yīng)用技術(shù)服務(wù)", "科研成果轉(zhuǎn)化", "科學(xué)產(chǎn)品銷售" ]。上海朝瑞科技順應(yīng)時(shí)代發(fā)展和市場(chǎng)需求，通過**技術(shù)，力圖保證高規(guī)格高質(zhì)量的[ "科研技術(shù)服務(wù)", "應(yīng)用技術(shù)服務(wù)", "科研成果轉(zhuǎn)化", "科學(xué)產(chǎn)品銷售" ]。</p></p><br /><p>文章來源地址: http://www.cdcfah.com/cp/997810.html</p></div></div></div></div></div><div id="nhz7qa3" class="page-right twoColRt"><div id="bvsp4ya" class="box01 margin10 clearfix"><h3><a 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