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src="https://tyunfile.71360.com/WaterMark/UploadFile/shlinchen/637291455777636719/5338422.png" class="vcenter" onerror="javascript:this.src='/static/new_net_01/images/nopic.jpg';"></p></div></div></div><div id="e2jy3pm" class="content"><p><span>需求數(shù)量：</span>0</p><p><span>價(jià)格要求：</span>面議</p><p><span>所在地：</span>上海市</p><p><span>包裝要求：</span><span style="color: #f30;"></span></p><p><span>產(chǎn)品關(guān)鍵詞：</span>北京蜂毒,蜂毒</p><p><span>***更新：</span>2021-01-30 06:08:31</p><p><span id="click" >瀏覽次數(shù)：0次</span></p><a rel="nofollow" class="button">聯(lián)系我們</a></div></div><div id="o8iauw2" class="rightbox"><h3>公司基本資料信息</h3><p style="border:0;"><a rel="nofollow">上海臨辰醫(yī)藥科技有限公司</a></p><p><span>聯(lián)系人：</span>葉海岑</p><p><span>郵箱: </span>info@linchenpharm.com</p><p><span>電話: </span>13761181955</p><p><span>傳真: </span>021_</p><p><span>網(wǎng)址: </span></p><p><span>手機(jī): </span>021-31606595</p><p><span>地址: </span>辰花路5088弄221號(hào)</p><p>[當(dāng)前離線] <a rel="nofollow"> [加為商友] </a><a rel="nofollow"> [發(fā)送信件] </a></p></div></div><div id="vobyf29" class="page-proshow02"><p class="title">詳細(xì)說(shuō)明</p><div id="i2su8vx" class="box"><p><p> 蜂毒是工蜂毒腺分泌出來(lái)的一種具有芳香氣味的成分復(fù)雜的混合物，主要含有蛋白質(zhì)多肽類(lèi)、酶類(lèi)、生物胺類(lèi)和其他物質(zhì)。蜂毒中研究較多的是蜂毒溶血肽，又稱(chēng)蜂毒肽(melittin)。蜂毒肽約占蜂毒干重的50%，也是蜂毒中具藥理作用和生物學(xué)活性的主要組分。MLT呈強(qiáng)堿性，易溶于水，相對(duì)分子質(zhì)量為2849，。2013年3月，美國(guó)科學(xué)家宣布，可以利用在蜂刺***中發(fā)現(xiàn)的化學(xué)物質(zhì)毀滅**毒，防止**傳播，但又不傷及周?chē)＜?xì)胞。 </p> <p> 尤其是蜂毒肽可以抗對(duì)青霉素具有耐藥性的金黃色葡萄球菌。蜂毒肽還能增強(qiáng)磺胺類(lèi)和青霉素類(lèi)***的***效力，對(duì)多種***、***也具0性，北京蜂毒。其對(duì)前列腺素合成酶的***作用是吲哚鎂辛的70倍，鎮(zhèn)痛強(qiáng)度為***的40%。實(shí)驗(yàn)研究證明，北京蜂毒，全蜂毒、蜂毒肽、神經(jīng)毒多肽、MCD均能刺激垂體腎上腺系統(tǒng)使皮質(zhì)***釋放增加而產(chǎn)生***作用，北京蜂毒。蜂毒肽還能***白細(xì)胞轉(zhuǎn)移. 蜂毒是蜜蜂蟄刺時(shí)排出的毒液，因價(jià)格昂貴且產(chǎn)量稀缺而被譽(yù)為“液體黃金”。北京蜂毒</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="北京蜂毒,蜂毒" src="https://tyunfile.71360.com/WaterMark/UploadFile/shlinchen/637291455777636719/5338422.png"></div><p> 蜂毒肽呈強(qiáng)堿性(pH=10)，易溶于水，它在蜂毒中起主要的藥理作用，是目前人類(lèi)所知***性**強(qiáng)的物質(zhì)之一。它具有類(lèi)似***的作用，卻不具有***的不良反應(yīng)。此外，亦具抑菌、抗輻射、抗病毒等作用。蜂毒肽還可以刺穿**毒的保護(hù)外層，毀滅**毒，但又不傷及周?chē)＜?xì)胞。近年來(lái)又有對(duì)其***作用進(jìn)行研究的報(bào)道。但是其臨床應(yīng)用卻有很多局限，主要原因是現(xiàn)有技術(shù)難以將蜂毒中有致敏反應(yīng)并與蜂毒肽分子量接近的磷脂酶A2完全去除。 </p> <p> 人類(lèi)社會(huì)利用蜂毒的歷史悠久，同時(shí)人們對(duì)蜂毒和蜂毒肽的研究也在不斷深入。自從1952年Neuman等人用電泳法分離獲得蜂毒肽以來(lái)，關(guān)于蜂毒肽的研究拉開(kāi)了帷幕，很多研究發(fā)現(xiàn)蜂毒肽對(duì)體內(nèi)外多種**細(xì)胞都有殺傷作用。北京蜂毒，還有透明質(zhì)酸酶、蜂毒磷脂酶及組胺等多種活性物質(zhì)，故有肽類(lèi)“寶庫(kù)”之稱(chēng)。</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="北京蜂毒,蜂毒" src="https://tyunfile.71360.com/WaterMark/UploadFile/shlinchen/637291455616943360/3384309.png"></div><p> "小蜜蜂"能鉆進(jìn)*細(xì)胞，釋放蜂毒肽，將*細(xì)胞一個(gè)個(gè)消滅掉。"小蜜蜂"內(nèi)部還有專(zhuān)門(mén)的定位物質(zhì)，能夠指引它一路前行，直達(dá)***。在實(shí)驗(yàn)中，"納米蜜蜂"已經(jīng)令患有乳腺*的小白鼠體內(nèi)的*細(xì)胞減少了45%，而患有皮膚*的小白鼠體內(nèi)的*細(xì)胞則銳減了75%之多。 </p> <p> <br /> </p> <p> 蜂毒肽是由26個(gè)氨基酸殘基組成的多肽，其一級(jí)結(jié)構(gòu)的氨基酸殘基順序?yàn)镚ly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-NH2 </p> <p> <br /> </p> <p> 在通常情況下，C-末端有4個(gè)氨基酸殘基攜帶正電荷，N-末端有2個(gè)氨基酸殘基攜帶正電荷，整個(gè)分子帶6個(gè)正電荷。蜂毒肽的N-末端起前20個(gè)氨基酸殘基主要是疏水的，C-末端的6個(gè)氨基酸殘基主要是親水的。 </p> <p> <br /> </p><p> 2000年，王關(guān)林等從蜜蜂毒腺中提取總RNA，通過(guò)RT-PCR方法擴(kuò)增得到了蜂毒肽前體蛋白的cDNA，再進(jìn)一步通過(guò)定點(diǎn)誘變?cè)诜涠倦男蛄星耙肓私?jīng)胺裂解位點(diǎn)，構(gòu)建了與β-半乳糖苷酶部分序列相融合的蜂毒肽誘變蛋白表達(dá)載體，序列分析結(jié)果表明，他們成功地引入了目的密碼子，且與β-半乳糖苷酶部分序列構(gòu)成正確的讀碼框，并在大腸桿菌中表達(dá)了誘變蛋白。 </p> <p> <br /> </p> <p> 2001年，黃雪強(qiáng)等通過(guò)人白血病細(xì)胞觀察蜂毒肽促凋亡的作用，結(jié)果發(fā)現(xiàn)對(duì)白血病細(xì)胞5mg/mL蜂毒肽作用4h與4μg/mL蜂毒肽作用24h都可見(jiàn)典型凋亡特征，進(jìn)一步實(shí)驗(yàn)發(fā)現(xiàn)其誘導(dǎo)細(xì)胞凋亡同bcl-2基因表達(dá)***下降相關(guān)。蜂毒就是提取蜜蜂身上的毒液。但這種毒液卻不會(huì)對(duì)人體造成傷害，反而是種珍稀的護(hù)膚液體</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="北京蜂毒,蜂毒" src="https://tyunfile.71360.com/WaterMark/UploadFile/shlinchen/637291456095595704/9364780.png"></div><p style="text-indent:25px">1997年，李繼周等通過(guò)mRNA-cDNA反轉(zhuǎn)錄的方法合成了蜂毒肽基因，用λgt11建立了蜂毒肽的cDNA文庫(kù)，并用抗體探針篩選出能夠表達(dá)蜂毒溶血肽的陽(yáng)性克隆。 Benachir等利用鈣黃綠素作為熒光標(biāo)記物，系統(tǒng)研究了蜂毒肽誘導(dǎo)的膜滲漏。認(rèn)為蜂毒肽與囊泡的結(jié)合會(huì)非常迅速，而且在蜂毒肽作用下，有的囊泡的內(nèi)容物全部釋放，而有的則保持完整。內(nèi)容物釋放的比例與蜂毒肽/脂質(zhì)的摩爾比率有關(guān)。更為特別的是蜂毒肽可以區(qū)別出完整的和已經(jīng)有物質(zhì)滲出的囊泡，而且表明卵磷脂雙分子層表面負(fù)電荷的存在對(duì)蜂毒肽的裂解能力有***作用，并且與負(fù)電荷的密度成一定比例。蜂毒中富含的酶類(lèi)等活性物質(zhì)能***凝血活酶活性并能***凝血酶原***物生成。北京蜂毒</p><p style="text-indent:25px">用于工業(yè)生產(chǎn)的蜂毒主要有兩種。北京蜂毒</p><p> 據(jù)此推測(cè)，可能與在高濃度中蜂毒肽的自聚集相關(guān)，高濃度下多呈四聚體的狀態(tài)，與單體相比更能與細(xì)胞膜有效地結(jié)合，進(jìn)而形成離子通道，改變胞膜通透性，裂解胞膜，表現(xiàn)出極強(qiáng)的體外殺傷**的效果。 </p> <p> <br /> </p> <p> 2004年，李柏、張晨等應(yīng)用基因工程研究證明，蜂***具有誘導(dǎo)**細(xì)胞凋亡的作用。經(jīng)攜蜂***基因重組腺病毒轉(zhuǎn)染后，倒置相差顯微鏡下觀察到部分肝*細(xì)胞出現(xiàn)凋亡形態(tài)學(xué)變化，體積變小、變圓，染色質(zhì)邊集等現(xiàn)象。攜蜂***基因重組腺病毒可有效誘導(dǎo)肝*細(xì)胞凋亡，凋亡率在20%左右，高于不含基因重組腺病毒和未轉(zhuǎn)染重組腺病毒對(duì)照組，提示誘導(dǎo)**細(xì)胞凋亡亦是蜂***基因***發(fā)揮作用的機(jī)制之一。北京蜂毒</p></p><br /><p>文章來(lái)源地址: http://www.cdcfah.com/cp/3076702.html</p></div></div></div></div></div><div id="yfcj7zw" class="page-right twoColRt"><div id="mb73ol3" class="box01 margin10 clearfix"><h3><a href="http://www.cdcfah.com/cp/">猜你喜歡</a></h3><div id="8yfcghj" class="recomPic likePro"><a href="http://www.cdcfah.com/cp/814588.html"><div><img src="http://tyunfile.71360.com/UpLoadFile/2019/11/1/14/637082168864691056_lgpj_5374157.jpg" alt="福建ZF配件哪家強(qiáng) 信息推薦自業(yè)物資供應(yīng)" class="vcenter" 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