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href="http://www.cdcfah.com/xw/"><span>行業(yè)資訊</span></a></li><li id = "index_show"><a href="http://www.cdcfah.com/zh/"><span>展會(huì)信息</span></a></li></ul></div></nav><section class="wrap clearfix"><section class="container clearfix tcPro"><section class="home-main container clearfix"><div id="csx3dof" class="twoCol"><div id="qoabcd3" class="page-proshow clearfix"><p class="current"> 當(dāng)前位置:<a href="http://www.cdcfah.com/">首頁(yè)?<a href="http://www.cdcfah.com/cp/">產(chǎn)品供應(yīng)</a>?<a href="http://www.cdcfah.com/cp/second-_yyby/">醫(yī)藥健康</a>?<a href="http://www.cdcfah.com/cp/third-yyby_zyfl/">制藥輔料</a>?l-泛解酸內(nèi)酯合成上海臨辰供應(yīng)</p><div id="uw2e8tk" class="leftbox clearfix"><h1>l-泛解酸內(nèi)酯合成上海臨辰供應(yīng)</h1><div id="8x8dr7k" class="proBig"><div id="x88pque" class="bigimg"><div><p class="pic"><img src="https://tyunfile.71360.com/WaterMark/UploadFile/shlinchen/637278336180390625/6214460.png" class="vcenter" onerror="javascript:this.src='/static/new_net_01/images/nopic.jpg';"></p></div></div><div id="s4ke7ea" class="smallimg"><div><p class="pic"><img src="https://tyunfile.71360.com/WaterMark/UploadFile/shlinchen/637278336180390625/6214460.png" class="vcenter" onerror="javascript:this.src='/static/new_net_01/images/nopic.jpg';"></p></div></div></div><div id="bw378nt" class="content"><p><span>需求數(shù)量：</span>0</p><p><span>價(jià)格要求：</span>面議</p><p><span>所在地：</span>上海市</p><p><span>包裝要求：</span><span style="color: #f30;"></span></p><p><span>產(chǎn)品關(guān)鍵詞：</span>l-泛解酸內(nèi)酯合成</p><p><span>***更新：</span>2020-06-24 03:26:25</p><p><span id="click" >瀏覽次數(shù)：0次</span></p><a rel="nofollow" class="button">聯(lián)系我們</a></div></div><div id="x4cdulm" class="rightbox"><h3>公司基本資料信息</h3><p style="border:0;"><a rel="nofollow">上海臨辰醫(yī)藥科技有限公司</a></p><p><span>聯(lián)系人：</span>葉海岑</p><p><span>郵箱: </span>info@linchenpharm.com</p><p><span>電話: </span>13761181955</p><p><span>傳真: </span>021_</p><p><span>網(wǎng)址: </span></p><p><span>手機(jī): </span>021-31606595</p><p><span>地址: </span>辰花路5088弄221號(hào)</p><p>[當(dāng)前離線] <a rel="nofollow"> [加為商友] </a><a rel="nofollow"> [發(fā)送信件] </a></p></div></div><div id="nn89yok" class="page-proshow02"><p class="title">詳細(xì)說(shuō)明</p><div id="gwmntuf" class="box"><p><p style="text-indent:25px">KATAOKA M 等于1992 年分離純化出星狀諾卡氏菌生產(chǎn)的L-泛解酸內(nèi)酯脫氫酶，但比酶活只有0，l-泛解酸內(nèi)酯合成.041 7 U/mg。該菌的基因組信息已被披露，然而至今未有構(gòu)建其L-泛解酸內(nèi)酯脫氫酶基因工程菌的報(bào)道。2009 年，王永澤等利用面包酵母生產(chǎn)酮泛解酸內(nèi)酯還原酶，并利用β-環(huán)糊精結(jié)合底物，l-泛解酸內(nèi)酯合成，減少底物對(duì)菌體的0作用，終產(chǎn)物得率達(dá)45%，光學(xué)純度達(dá)到90%以上。SI D等于2012 年在嗜麥芽寡養(yǎng)單孢菌845 中克隆一個(gè)大小約為30 kDa 的酮泛解酸還原酶，并與葡萄糖脫氫酶共表達(dá)成大腸工程菌，構(gòu)建輔酶循環(huán)體系，l-泛解酸內(nèi)酯合成。該大腸工程菌的酮泛解酸還原酶的比酶活達(dá)到27.7 U/mg。</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="l-泛解酸內(nèi)酯合成" src="https://tyunfile.71360.com/WaterMark/UploadFile/shlinchen/637278336180390625/6214460.png"></div><p> 傳統(tǒng)的生產(chǎn)方法是化學(xué)拆分法或鈣鹽誘導(dǎo)結(jié)晶法。化學(xué)拆分的缺點(diǎn)是拆分劑太貴，分離困難，步驟多，成本高，還0性和環(huán)境污染問(wèn)題。鈣鹽誘導(dǎo)結(jié)晶法步驟多，收率低，投資大，擴(kuò)大生產(chǎn)規(guī)模比較困難。另外，誘導(dǎo)結(jié)晶法不能用于D－泛醇等泛酸衍生物生產(chǎn)。 </p> <p> “微生物酶法拆分制備D－泛解酸內(nèi)酯及用于生產(chǎn)D－泛酸鈣與D－泛醇”項(xiàng)目選育了一株能高產(chǎn)立體專一性D－泛解酸內(nèi)酯水解酶、不利用不降解泛解酸內(nèi)酯或泛解酸的微生物菌株串珠鐮孢霉，建立了國(guó)際**的霉菌交聯(lián)原位固定化方法，酶轉(zhuǎn)化時(shí)間短到3～5小時(shí)，效率高，反復(fù)分批酶轉(zhuǎn)化可達(dá)180次以上，所得到的酶水解產(chǎn)物光學(xué)純度達(dá)到99％e．e．以上，因此具有較好的技術(shù)經(jīng)濟(jì)競(jìng)爭(zhēng)力。 </p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="l-泛解酸內(nèi)酯合成" src="https://tyunfile.71360.com/WaterMark/UploadFile/shlinchen/637278336299169921/7145872.png"></div><p> 化學(xué)酶法合成D-泛解酸內(nèi)酯 </p> <p> 泛酸具有一個(gè)手性中心，其中D-泛酸是工業(yè)生產(chǎn)所需要的。化學(xué)法合成D-泛酸（或泛酸鈣）工藝成熟，但步驟繁瑣且對(duì)消旋化產(chǎn)物進(jìn)行結(jié)晶拆分費(fèi)用昂貴。利用生物酶法生產(chǎn)光學(xué)純的D-泛酸可進(jìn)一步升級(jí)合成工藝，提升產(chǎn)品的競(jìng)爭(zhēng)力。生物酶法主要包括利用生物菌體發(fā)酵生產(chǎn)和酶法催化。生物菌體發(fā)酵法利用基因工程技術(shù)在大腸桿菌、谷氨酸棒狀桿菌、枯草芽孢桿菌和釀酒酵母等宿主菌中表達(dá)泛酸生物合成基因和氨基酸生物合成基因，并利用基因工程菌進(jìn)行微生物發(fā)酵，泛酸產(chǎn)量較高，但微生物發(fā)酵法發(fā)酵液成分復(fù)雜，后續(xù)的產(chǎn)物分離提取較困難。酶法催化可以替代化學(xué)反應(yīng)過(guò)程中的某些步驟，以化學(xué)酶法的方式來(lái)實(shí)現(xiàn)D-泛酸的前體物質(zhì)D-泛酸內(nèi)酯的生產(chǎn)。目前國(guó)內(nèi)外酶法催化生產(chǎn)D-泛解酸內(nèi)酯的方法主要包括酶法選擇性拆分和酶法不對(duì)稱合成。關(guān)于酶法不對(duì)稱合成，筆者主要綜述了三種路線：1）前手性物質(zhì)酮泛解酸或酮泛解酸內(nèi)酯不對(duì)稱還原成D-泛解酸內(nèi)酯；2）利用(R)-羥基腈裂合酶來(lái)合成泛解酸內(nèi)酯前體羥基特戊醛；3）醇脫氫酶參與的化學(xué)酶法合成D-泛解酸內(nèi)酯。 </p> <p> <br /> </p></p><br /><p>文章來(lái)源地址: http://www.cdcfah.com/cp/369715.html</p></div></div></div></div></div><div id="mvhio7m" class="page-right twoColRt"><div id="om8ozq8" class="box01 margin10 clearfix"><h3><a href="http://www.cdcfah.com/cp/">猜你喜歡</a></h3><div 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