D+泛解酸內(nèi)酯有哪些品牌上海臨辰供應(yīng)-b2b網(wǎng)站_b2b電子商務(wù)平臺(tái)【買產(chǎn)品】-上?？谄蚴称酚邢薰?/title><meta name="description" content="泛酸,即維生素B5,***存在于生物界中,是動(dòng)物體內(nèi)合成輔酶A的主要原料,其主要作用是參與糖、脂肪和蛋白質(zhì)的代謝,***應(yīng)用于醫(yī)藥、飼料和食品等領(lǐng)域。D-泛解酸內(nèi)酯是D-泛酸合成過(guò)程中重要的手型中間體,生產(chǎn)D-泛酸的關(guān)鍵技術(shù)是DL-泛解酸內(nèi)"><meta name="keywords" content="D+泛解酸內(nèi)酯有哪些品牌"><link rel="canonical" href="http://www.cdcfah.com/"/><meta name="applicable-device" content="pc"><link rel="shortcut icon" href="/static/new_net_01/images/favicon.ico"><link rel="stylesheet" href="/static/new_net_01/css/slick.css" /><link rel="stylesheet" href="/static/new_net_01/css/addnew.css"><link rel="stylesheet" href="/static/new_net_01/css/sidenav.css"><link rel="stylesheet" href="/static/new_net_01/css/style.css" /><link rel="stylesheet" href="/static/new_net_01/css/tab.css"><link rel="stylesheet" href="/static/new_net_01/css/404.css"> <meta name="baidu-site-verification" content="OBVzrC9aaQ" /> <meta 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onerror="javascript:this.src='/static/new_net_01/images/nopic.jpg';"></p></div></div><div id="on3xw9v" class="smallimg"><div><p class="pic"><img src="https://tyunfile.71360.com/WaterMark/UploadFile//637280289561562500/2636284.png" class="vcenter" onerror="javascript:this.src='/static/new_net_01/images/nopic.jpg';"></p></div></div></div><div id="3ipe34n" class="content"><p><span>需求數(shù)量：</span>0</p><p><span>價(jià)格要求：</span>面議</p><p><span>所在地：</span>上海市</p><p><span>包裝要求：</span><span style="color: #f30;"></span></p><p><span>產(chǎn)品關(guān)鍵詞：</span>D+泛解酸內(nèi)酯有哪些品牌</p><p><span>***更新：</span>2020-06-28 14:28:12</p><p><span id="click" >瀏覽次數(shù)：0次</span></p><a rel="nofollow" class="button">聯(lián)系我們</a></div></div><div id="mgim3th" class="rightbox"><h3>公司基本資料信息</h3><p style="border:0;"><a rel="nofollow">上海臨辰醫(yī)藥科技有限公司</a></p><p><span>聯(lián)系人：</span>葉海岑</p><p><span>郵箱: </span>info@linchenpharm.com</p><p><span>電話: </span>13761181955</p><p><span>傳真: </span>021_</p><p><span>網(wǎng)址: </span></p><p><span>手機(jī): </span>021-31606595</p><p><span>地址: </span>辰花路5088弄221號(hào)</p><p>[當(dāng)前離線] <a rel="nofollow"> [加為商友] </a><a rel="nofollow"> [發(fā)送信件] </a></p></div></div><div id="9acmy4o" class="page-proshow02"><p class="title">詳細(xì)說(shuō)明</p><div id="pwmoaja" class="box"><p><p style="text-indent:25px">泛酸,即維生素B5,***存在于生物界中,是動(dòng)物體內(nèi)合成輔酶A的主要原料,其主要作用是參與糖、脂肪和蛋白質(zhì)的代謝,***應(yīng)用于醫(yī)藥、飼料和食品等領(lǐng)域。D-泛解酸內(nèi)酯是D-泛酸合成過(guò)程中重要的手型中間體,生產(chǎn)D-泛酸的關(guān)鍵技術(shù)是DL-泛解酸內(nèi)酯的手性拆分技術(shù)。對(duì)比采用昂貴手性拆分劑的化學(xué)拆分方法,微生物酶法拆分具有原料成本低,條件溫和,易于操作,環(huán)境友好等優(yōu)點(diǎn)。通過(guò)比較各種生物法的拆分路線,本課題采用選擇性水解D型內(nèi)酯的路線，D+泛解酸內(nèi)酯有哪些品牌，D+泛解酸內(nèi)酯有哪些品牌,即用D-立體專一內(nèi)酯水解酶水解消旋內(nèi)酯中的D-泛解酸內(nèi)酯，D+泛解酸內(nèi)酯有哪些品牌,得到D-泛解酸,再通過(guò)內(nèi)酯化得到D-泛解酸內(nèi)酯,而L-泛解酸內(nèi)酯經(jīng)過(guò)消旋化可以反復(fù)使用。</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="D+泛解酸內(nèi)酯有哪些品牌" src="https://tyunfile.71360.com/WaterMark/UploadFile//637280289561562500/2636284.png"></div><p> 微生物選擇性的不對(duì)稱水解DL-泛解酸內(nèi)酯中的D-泛解酸內(nèi)酯，得到D-泛解酸，再將D-泛解酸進(jìn)行內(nèi)酯化生產(chǎn)D-泛解酸內(nèi)酯。該方法工藝控制簡(jiǎn)單，微生物酶專一性好，可以得到高光學(xué)純度的D-泛解酸內(nèi)酯。 </p> <p> <br /> </p> <p> <br /> </p> <p> <br /> </p> <p> 利用D-泛解酸內(nèi)酯水解酶N末端序列,并根據(jù)NCBI中公布的D-泛解酸內(nèi)酯水解酶cDNA序列設(shè)計(jì)了一個(gè)特異引物,該引物結(jié)合Oligo(dT)15,以串珠鐮孢霉(Fusarium moniliforme)CGMCC 0536 mRNA反轉(zhuǎn)錄得到的總cDNA為模板進(jìn)行擴(kuò)增,獲得約1.5kb左右的片段,將其克隆到T載體上進(jìn)行測(cè)序,對(duì)測(cè)得的序列進(jìn)行分析,重新設(shè)計(jì)了一對(duì)引物,并在引物兩端分別加上限制酶EcoRI和SalI的識(shí)別位點(diǎn)序列,利用熱啟動(dòng)PCR成功地?cái)U(kuò)增出了D-泛解酸內(nèi)酯水解酶基因, </p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="D+泛解酸內(nèi)酯有哪些品牌" src="https://tyunfile.71360.com/WaterMark/UploadFile//637280289625869141/3735503.png"></div><p style="text-indent:25px">其中Kataoka M 等發(fā)現(xiàn)來(lái)源于根*農(nóng)桿菌的L-泛解酸內(nèi)酯水解酶有較高的活力和選擇性。Kesseler M 等對(duì)根*農(nóng)桿菌lu678 的L-泛解酸內(nèi)酯水解酶構(gòu)建大腸工程菌并過(guò)量表達(dá)該蛋白，酶活提高了200 倍，達(dá)到600 U/g。該過(guò)程要求L-泛解酸內(nèi)酯必須完全水解，才能獲得高光學(xué)純度的D-泛解酸內(nèi)酯，限制了其工業(yè)應(yīng)用。D-泛解酸內(nèi)酯水解酶選擇性水解拆分DL-泛解酸內(nèi)酯生成D-泛解酸，再經(jīng)內(nèi)酯化生成D-泛解酸內(nèi)酯，留下的L-泛解酸內(nèi)酯經(jīng)化學(xué)消旋化為DL-泛解酸內(nèi)酯重新循環(huán)拆分。D-泛解酸內(nèi)酯水解酶來(lái)源豐富，其中**常用的是鐮飽霉菌，有尖孢鐮刀菌、腐皮鐮刀菌和串珠鐮刀菌。2007 年，SAKAMOTO K等利用固定化的尖孢鐮刀菌來(lái)水解拆分DL-泛解酸內(nèi)酯，固定化細(xì)胞的半衰期可以達(dá)到6 000h，經(jīng)過(guò)180次重復(fù)利用后仍然保持原活力的71%，相對(duì)于游離的整細(xì)胞催化其半衰期提高了35 倍。</p></p><br /><p>文章來(lái)源地址: http://www.cdcfah.com/cp/424376.html</p></div></div></div></div></div><div id="8uv8xl7" class="page-right twoColRt"><div id="hqxzbar" class="box01 margin10 clearfix"><h3><a href="http://www.cdcfah.com/cp/">猜你喜歡</a></h3><div id="lkri3oa" class="recomPic likePro"><a href="http://www.cdcfah.com/cp/814588.html"><div><img src="http://tyunfile.71360.com/UpLoadFile/2019/11/1/14/637082168864691056_lgpj_5374157.jpg" alt="福建ZF配件哪家強(qiáng) 信息推薦自業(yè)物資供應(yīng)" 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