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class="pic"><img src="https://tyunfile.71360.com/WaterMark/UploadFile//637280289625869141/3735503.png" class="vcenter" onerror="javascript:this.src='/static/new_net_01/images/nopic.jpg';"></p></div></div><div id="g3lm2bp" class="smallimg"><div><p class="pic"><img src="https://tyunfile.71360.com/WaterMark/UploadFile//637280289625869141/3735503.png" class="vcenter" onerror="javascript:this.src='/static/new_net_01/images/nopic.jpg';"></p></div></div></div><div id="zsjqepg" class="content"><p><span>需求數(shù)量：</span>0</p><p><span>價(jià)格要求：</span>面議</p><p><span>所在地：</span>上海市</p><p><span>包裝要求：</span><span style="color: #f30;"></span></p><p><span>產(chǎn)品關(guān)鍵詞：</span>***泛解酸內(nèi)酯等級(jí),泛解酸內(nèi)酯</p><p><span>***更新：</span>2020-07-04 06:23:00</p><p><span id="click" >瀏覽次數(shù)：0次</span></p><a rel="nofollow" class="button">聯(lián)系我們</a></div></div><div id="enokw23" class="rightbox"><h3>公司基本資料信息</h3><p style="border:0;"><a rel="nofollow">上海臨辰醫(yī)藥科技有限公司</a></p><p><span>聯(lián)系人：</span>葉海岑</p><p><span>郵箱: </span>info@linchenpharm.com</p><p><span>電話: </span>13761181955</p><p><span>傳真: </span>021_</p><p><span>網(wǎng)址: </span></p><p><span>手機(jī): </span>021-31606595</p><p><span>地址: </span>辰花路5088弄221號(hào)</p><p>[當(dāng)前離線] <a rel="nofollow"> [加為商友] </a><a rel="nofollow"> [發(fā)送信件] </a></p></div></div><div id="f7bszfl" class="page-proshow02"><p class="title">詳細(xì)說明</p><div id="ene787m" class="box"><p><p> 化學(xué)酶法合成D-泛解酸內(nèi)酯 </p> <p> 泛酸具有一個(gè)手性中心，其中D-泛酸是工業(yè)生產(chǎn)所需要的?；瘜W(xué)法合成D-泛酸（或泛酸鈣）工藝成熟，但步驟繁瑣且對(duì)消旋化產(chǎn)物進(jìn)行結(jié)晶拆分費(fèi)用昂貴，***泛解酸內(nèi)酯等級(jí)。利用生物酶法生產(chǎn)光學(xué)純的D-泛酸可進(jìn)一步升級(jí)合成工藝，提升產(chǎn)品的競爭力。生物酶法主要包括利用生物菌體發(fā)酵生產(chǎn)和酶法催化，***泛解酸內(nèi)酯等級(jí)。生物菌體發(fā)酵法利用基因工程技術(shù)在大腸桿菌、谷氨酸棒狀桿菌、枯草芽孢桿菌和釀酒酵母等宿主菌中表達(dá)泛酸生物合成基因和氨基酸生物合成基因，并利用基因工程菌進(jìn)行微生物發(fā)酵，泛酸產(chǎn)量較高，但微生物發(fā)酵法發(fā)酵液成分復(fù)雜，***泛解酸內(nèi)酯等級(jí)，后續(xù)的產(chǎn)物分離提取較困難。酶法催化可以替代化學(xué)反應(yīng)過程中的某些步驟，以化學(xué)酶法的方式來實(shí)現(xiàn)D-泛酸的前體物質(zhì)D-泛酸內(nèi)酯的生產(chǎn)。目前國內(nèi)外酶法催化生產(chǎn)D-泛解酸內(nèi)酯的方法主要包括酶法選擇性拆分和酶法不對(duì)稱合成。關(guān)于酶法不對(duì)稱合成，筆者主要綜述了三種路線：1）前手性物質(zhì)酮泛解酸或酮泛解酸內(nèi)酯不對(duì)稱還原成D-泛解酸內(nèi)酯；2）利用(R)-羥基腈裂合酶來合成泛解酸內(nèi)酯前體羥基特戊醛；3）醇脫氫酶參與的化學(xué)酶法合成D-泛解酸內(nèi)酯。 </p> <p> <br /> 將所述酮泛解酸在α?酮異戊酸還原酶的作用下，進(jìn)行酶轉(zhuǎn)化得到泛解酸。***泛解酸內(nèi)酯等級(jí)</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="***泛解酸內(nèi)酯等級(jí),泛解酸內(nèi)酯" src="https://tyunfile.71360.com/WaterMark/UploadFile//637280289625869141/3735503.png"></div><p> D-泛解酸內(nèi)酯的傳統(tǒng)工業(yè)方法是化學(xué)拆分法和生物拆分法。 </p> <p> <br /> </p> <p> 這兩種方法生產(chǎn)過程復(fù)雜，拆分試劑制備回收繁瑣，生產(chǎn)成本高。 </p> <p> <br /> </p> <p> 探求其新的拆分方法，完善生產(chǎn)工藝，提高產(chǎn)品質(zhì)量，一直成為研究者和生產(chǎn)者追求的目的。 </p> <p> <br /> </p> <p> 實(shí)質(zhì)上在拆分工藝的三種傳統(tǒng)方法中（化學(xué)拆分、生物拆分、誘導(dǎo)拆分）。 </p> <p> <br /> </p> <p> 生產(chǎn)D-泛酸鈣進(jìn)行了幾十年的摸索，先后采用了誘導(dǎo)拆分DL-泛酸鈣法、化學(xué)拆分D-泛解酸內(nèi)酯法和生物拆分法。 </p> <p> <br /> </p> <p> 生產(chǎn)D-泛酸鈣，近年來拆分方法基本上統(tǒng)一到了生物拆分制備法。 ***泛解酸內(nèi)酯等級(jí)用微生物酶將 D, L-泛解酸內(nèi)酯拆分得到 D-泛解酸內(nèi)酯，與 B再一丙氨酸鈣縮合生產(chǎn) D-泛酸鈣。</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="***泛解酸內(nèi)酯等級(jí),泛解酸內(nèi)酯" src="https://tyunfile.71360.com/WaterMark/UploadFile/shlinchen/637278336133632812/8293857.png"></div><p> D-(-)-泛酰內(nèi)酯 CAS： 599-04-2。 </p> <p> <br /> </p> <p> 化合物中文學(xué)名 D-(-)-泛酰內(nèi)酯。 </p> <p> <br /> </p> <p> 中文別名:(3R)-二氫-3-羥基-4,4-二甲基-2(3H)-呋喃酮。 </p> <p> <br /> </p> <p> 中文別名:D-泛解酸內(nèi)酯。 </p> <p> <br /> </p> <p> 中文別名:D-(-)-泛酰內(nèi)酯。 </p> <p> <br /> </p> <p> 中文別名: (R)-3-羥基-4,4-二甲基-二氫-2(3H)-呋喃酮。 </p> <p> <br /> </p> <p> 中文別名:D-(-)-Pantolactone </p> <p> D-(-)-泛酰內(nèi)酯。 </p> <p> <br /> </p> <p> 中文別名:D(-)-泛酰內(nèi)酯。 </p> <p> <br /> </p> <p> 中文別名:D-泛酰內(nèi)酯。 </p> <p> <br /> </p> <p> 中文別名:α-羥基-β,β-二甲基-γ-丁內(nèi)酯。 </p> <p> <br /> </p> <p> 中文別名:二氫-3-羥基-4,4-二甲基-2(3H)呋喃酮。 </p> <p> <br /> </p> <p> 化合物英文學(xué)名 (D)-Pantolactone 。 </p> <p> <br /> </p> <p> D-泛解酸內(nèi)酯CAS號(hào)599-04-2。 </p> <p> <br /> </p> <p> D-泛解酸內(nèi)酯分子式 C6H10O3 。 </p> <p> <br /> </p> <p> D-泛解酸內(nèi)酯含量：99%。 </p> <p> <br /> </p> <p> 泛解酸內(nèi)酯性狀：白色晶體。 </p> <p> <br /> </p> <p> D-泛解酸內(nèi)酯是一種混旋泛酸鈣的中間體。 </p><p> SHIMIZU S 等進(jìn)一步研究發(fā)現(xiàn)一株紅串紅球菌可以直接完成該氧化還原過程，說明紅串紅球菌自身不*可以產(chǎn)L-泛解酸內(nèi)酯脫氫酶，還可以產(chǎn)還原過程所需的酮泛解酸內(nèi)酯還原酶。同時(shí)他們還提出酮泛解酸內(nèi)酯在中性pH 條件下會(huì)發(fā)生自發(fā)水解形成酮泛解酸，酮泛解酸再經(jīng)過大腸 </p> <p> 桿菌中酮泛解酸還原酶催化形成D-泛解酸，而后在酸性條件下閉環(huán)成D-泛解酸內(nèi)酯，這就解釋了1973 年發(fā)現(xiàn)酮泛解酸還原酶延滯2.2 min起作用的原因。 </p> <p> <br /> </p> <p> D-泛解酸內(nèi)酯是合成D-泛酸的重要中間體。 </p> <p> <br /> D-泛酸存在于植物以及低等生物的代謝過程中，被稱為遍多酸或本多酸，是水溶性維生素B族的一種。</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="***泛解酸內(nèi)酯等級(jí),泛解酸內(nèi)酯" src="https://tyunfile.71360.com/WaterMark/UploadFile/shlinchen/637278338760781250/415124.png"></div><p> 以水和甲苯為溶劑體系，通過添加D-泛解酸內(nèi)酯作為晶種，誘導(dǎo)結(jié)晶獲得D-泛解酸內(nèi)酯的方法。 </p> <p> <br /> </p> <p> 但本法在生產(chǎn)過程中用了甲苯，生產(chǎn)過程VOC排放較高，且通過誘導(dǎo)結(jié)晶獲得的一次收率較低，產(chǎn)品比旋度較低。 </p> <p> <br /> </p> <p> D-泛解酸內(nèi)酯的工業(yè)制備是由DL-泛解酸內(nèi)酯拆分而來的。 </p> <p> <br /> </p> <p> 作為一種重要的醫(yī)藥中間體，主要用于合成維生素類藥D-泛醇及神經(jīng)營養(yǎng)藥D-泛酸鈣。 </p> <p> <br /> </p> <p> D-泛酸鈣是維生素B5，作為重要的營養(yǎng)成分，***用于飼料添加劑、食品添加劑、醫(yī)藥等領(lǐng)域； </p> <p> <br /> </p> <p> D-泛醇是維生素原B5，***用于護(hù)發(fā)用品和化妝品中。 </p> <p> <br /> 利用天然氣合成氫氰酸生產(chǎn)泛解酸內(nèi)酯。***泛解酸內(nèi)酯等級(jí)</p><p style="text-indent:25px">D-泛酸鈣世界市場年消費(fèi)量約30000噸。***泛解酸內(nèi)酯等級(jí)</p><p style="text-indent:25px">維生素B5（VitaminB5）又稱D-維生素B5，是人體必需的13種維生素之一，是一種水溶性維生素，維生素B族成員之一，是它是輔酶a（CoA）及?；d體蛋白（acylcarrierprotein,acp）的組成部分。機(jī)體內(nèi)的泛酸，幾乎都用以組成輔酶a及acp的輔基。VB5前段生產(chǎn)工藝有多種，生產(chǎn)后段拆分方法有化學(xué)和微生物酶拆法兩種。VB5（D-維生素B5）首先要制備2個(gè)重要的中間體，分別為β-氨基丙酸和DL-泛解酸內(nèi)酯。β-氨基丙酸的合成有丙烯腈路線、丙烯酸路線、琥珀酰亞胺路線等，現(xiàn)國內(nèi)生產(chǎn)廠大多采用丙烯腈路線。***泛解酸內(nèi)酯等級(jí)</p><p style="text-indent:25px">上海臨辰醫(yī)藥科技有限公司于2016-04-05成立，注冊(cè)資本100-200萬元元，現(xiàn)有專業(yè)技術(shù)人員5~10人人，各種專業(yè)人員齊備。致力于創(chuàng)造***的產(chǎn)品與服務(wù)，以誠信、敬業(yè)、進(jìn)取為宗旨，以建Domanchem,多曼,NEXIRA,Ashland,BASF,Evonik,ROQUETTE,DFE,JBCOCO,JRS,BENOE,GIFU,StrahlPitsch,CYCLOLAB,SDFine,Avantor,Sudeep,Ambuja,Animo,kyowa-chem,caps-roxlor,MSI,CABOT,Danisco,DoPant,Sasol,Seppic,Clariant,Solvay,EASTMAN,DSM,Pfanstiehl,ANGUS,Cargill,Hopax,IMERYS,KEONOS,KIMICA,LYSI,MERCK,SABINSA,Vertellus,Watson明星產(chǎn)品為目標(biāo)，努力打造成為同行業(yè)中具有影響力的企業(yè)。公司不**提供專業(yè)的Plasdone?聚維酮(PVP)，Polyplasdone?交聯(lián)聚維酮(PVPP)，Plasdone?共聚維酮（PVP/VA)，Benecel?羥丙甲纖維素(HPMC)，Klucel?羥丙纖維素(HPC) 硬脂富馬酸鈉，羧甲基淀粉鈉，交聯(lián)羧甲基纖維素鈉，微晶纖維素，磷酸氫鈣（無水/二水）USP-NF,Ph.Eur,JP" D-(+)-半乳糖（植物）蔗糖，異麥芽糖，異麥芽酮糖醇，三氯蔗糖，環(huán)氨酸鈉（甜蜜素)，赤蘚糖醇丁香酚，丁香油，蓖麻油，芝麻油，橄欖油，中鏈甘油三酸酯，乙酰單酸甘油乙酯，蔗糖脂肪酸酯聚乙二醇3350/1000/4000/6000/8000，白陶土，液體石蠟，輕質(zhì)液體石蠟，（干燥）氫氧化鋁凝膠，薄荷腦，合成鋁碳酸鎂，合成硅酸鋁，氧化鎂，氫氧化鎂，甘羥鋁，甘氨酸鋁，磷酸鈣（二水/無水），三硅酸鎂，滑石粉，BHA,BHT,多庫酯鈉，組氨酸，鹽酸組氨酸，精氨酸，鹽酸精氨酸，絲氨酸，半胱氨酸，丙氨酸， Pfanstiehl海藻糖（二水），蔗糖（甘蔗/甜菜），甘露醇，精氨酸，琥珀酸二鈉（無水），氨丁三醇 (含低內(nèi)*素），活性炭（供注射）色素系列黃/紅氧化鐵，檸檬黃色淀，,同時(shí)還建立了完善的售后服務(wù)體系,為客戶提供質(zhì)量的產(chǎn)品和服務(wù)。上海臨辰醫(yī)藥科技有限公司主營業(yè)務(wù)涵蓋[ "泛解酸內(nèi)酯", "有機(jī)可可粉有機(jī)果粉", "阿拉伯膠瓜爾膠 ", "BIS TRIS " ]，堅(jiān)持“質(zhì)量***、質(zhì)量服務(wù)、顧客滿意”的質(zhì)量方針，贏得廣大客戶的支持和信賴。</p></p><br /><p>文章來源地址: http://www.cdcfah.com/cp/488606.html</p></div></div></div></div></div><div id="po2iev7" class="page-right twoColRt"><div id="8l2klhs" class="box01 margin10 clearfix"><h3><a href="http://www.cdcfah.com/cp/">猜你喜歡</a></h3><div id="2jhnzvm" class="recomPic likePro"><a href="http://www.cdcfah.com/cp/814588.html"><div><img src="http://tyunfile.71360.com/UpLoadFile/2019/11/1/14/637082168864691056_lgpj_5374157.jpg" alt="福建ZF配件哪家強(qiáng) 信息推薦自業(yè)物資供應(yīng)" class="vcenter" onerror="javascript:this.src='/static/new_net_01/images/nopic.jpg';"></div><p>福建ZF配件哪家強(qiáng) 信息推薦自業(yè)物資供應(yīng)</p></a></div><div id="88hsoal" class="recomPic likePro"><a 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