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class="wrap clearfix"><section class="container clearfix tcPro"><section class="home-main container clearfix"><div id="uy38pn7" class="twoCol"><div id="dhwj2mt" class="page-proshow clearfix"><p class="current"> 當(dāng)前位置:<a href="http://www.cdcfah.com/">首頁?<a href="http://www.cdcfah.com/cp/">產(chǎn)品供應(yīng)</a>?<a href="http://www.cdcfah.com/cp/second-_yyby/">醫(yī)藥健康</a>?<a href="http://www.cdcfah.com/cp/third-yyby_yyxmhz/">醫(yī)藥項目合作</a>?山西蜂毒上海臨辰供應(yīng)</p><div id="7x7ub37" class="leftbox clearfix"><h1>山西蜂毒上海臨辰供應(yīng)</h1><div id="hvwtvpd" class="proBig"><div id="qf28z7b" class="bigimg"><div><p class="pic"><img src="https://tyunfile.71360.com/WaterMark/UploadFile/shlinchen/637291455616943360/3384309.png" class="vcenter" onerror="javascript:this.src='/static/new_net_01/images/nopic.jpg';"></p></div></div><div id="3nceln3" class="smallimg"><div><p class="pic"><img src="https://tyunfile.71360.com/WaterMark/UploadFile/shlinchen/637291455616943360/3384309.png" class="vcenter" onerror="javascript:this.src='/static/new_net_01/images/nopic.jpg';"></p></div></div></div><div id="wa3iurb" class="content"><p><span>需求數(shù)量：</span>0</p><p><span>價格要求：</span>面議</p><p><span>所在地：</span>上海市</p><p><span>包裝要求：</span><span style="color: #f30;"></span></p><p><span>產(chǎn)品關(guān)鍵詞：</span>山西蜂毒,蜂毒</p><p><span>***更新：</span>2020-07-18 08:21:04</p><p><span id="click" >瀏覽次數(shù)：0次</span></p><a rel="nofollow" class="button">聯(lián)系我們</a></div></div><div id="rlya2ro" class="rightbox"><h3>公司基本資料信息</h3><p style="border:0;"><a rel="nofollow">上海臨辰醫(yī)藥科技有限公司</a></p><p><span>聯(lián)系人：</span>葉海岑</p><p><span>郵箱: </span>info@linchenpharm.com</p><p><span>電話: </span>13761181955</p><p><span>傳真: </span>021_</p><p><span>網(wǎng)址: </span></p><p><span>手機: </span>021-31606595</p><p><span>地址: </span>辰花路5088弄221號</p><p>[當(dāng)前離線] <a rel="nofollow"> [加為商友] </a><a rel="nofollow"> [發(fā)送信件] </a></p></div></div><div id="k8e3oi8" class="page-proshow02"><p class="title">詳細(xì)說明</p><div id="7k3pr2r" class="box"><p><p> 2001年，黃雪強等通過人白血病細(xì)胞觀察蜂毒肽促凋亡的作用，結(jié)果發(fā)現(xiàn)對白血病細(xì)胞5mg/mL蜂毒肽作用4h與4μg/mL蜂毒肽作用24h都可見典型凋亡特征，進(jìn)一步實驗發(fā)現(xiàn)其誘導(dǎo)細(xì)胞凋亡同bcl-2基因表達(dá)***下降相關(guān)。 </p> <p> 王秋波等通過人工合成含特異性酶切位點的AB兩條寡核苦酸片段，在Klenow酶作用下形成目的基因，用限制型內(nèi)切酶HindⅢ，山西蜂毒，XmnⅠ同時酶切目的基因和表達(dá)載體Pmal-p2質(zhì)粒，山西蜂毒，在T4連接酶的作用下構(gòu)建兩者的重組體，山西蜂毒，通過α-互補篩選出附性克隆，并通過特異性酶切和測序分析進(jìn)行鑒定，獲得重組蜂毒肽的原核表達(dá)克隆。蜂毒中富含的蜂毒肽也能*****細(xì)胞且不影響正常細(xì)胞生長。山西蜂毒</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="山西蜂毒,蜂毒" src="https://tyunfile.71360.com/WaterMark/UploadFile/shlinchen/637291455616943360/3384309.png"></div><p> 抗輻射的作用 1967年美國的希普曼和高萊，1968年金斯伯格，1978年俄國的阿爾捷莫夫都報道過蜂毒的抗X射線作用。阿爾捷莫夫不僅證實了注射蜂毒防護(hù)輻射的作 </p> <p> 用，還有***作用。1970年日本太阪的官野巖男，用鈷60作照射源，證實蜂毒有抗伽瑪射線的作用。蜂毒的輻射防護(hù)效應(yīng)主要作用是引起神經(jīng)內(nèi)分秘反應(yīng)，增強機體抗輻射作用 </p> <p> 致畸致突變的作用蜂毒肽為蜂毒除掉致敏、致痛成分新保留***作用的多肚類物質(zhì)，它主要包括蜂***曲(溶血活性肽)、神經(jīng)***、肥大細(xì)胞脫顆粒肽、心臟肽等，蜂毒 </p> <p> 肽對實驗性昆明種小鼠無致突變、致畸作用 J此外．蜂毒能興奮離體腸管和子官平滑肌，對大鼠有一定程度的抗肝纖維化作用＆吸收已形成的肝纖維化作用。 </p> <p> <br /> 山西蜂毒蜂毒中富含蜂毒肽和蜂毒明肽等天然***物質(zhì)。</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="山西蜂毒,蜂毒" src="https://tyunfile.71360.com/WaterMark/UploadFile/shlinchen/637293699074541015/5782620.png"></div><p> 在通常情況下，C-末端有4個氨基酸殘基攜帶正電荷，N-末端有2個氨基酸殘基攜帶正電荷，整個分子帶6個正電荷。蜂毒肽的N-末端起前20個氨基酸殘基主要是疏水的，C-末端的6個氨基酸殘基主要是親水的。 </p> <p> <br /> </p> <p> 分子的3個賴氨酸和2個精氨酸殘基使其成為強堿性肽，在中性水溶液中，蜂毒肽作為單體是以隨機的卷曲結(jié)構(gòu)存在的，而隨著pH值以及離子強度的增高，蜂毒肽自我交聯(lián)，形成螺旋的四聚體結(jié)構(gòu)，有研究發(fā)現(xiàn)在不同的溶液中蜂毒肽的螺旋結(jié)構(gòu)區(qū)域及螺旋間的角度是不同的。螺旋結(jié)構(gòu)中前21個氨基酸是極性的，位于螺旋的表面，而非極性氨基酸在螺旋的另一面。其兩親性(am-phiphilie)是膜結(jié)合肽和膜蛋白跨膜螺旋的特征。所以這個特性決定蜂毒肽既可以溶于水中，又可以與膜自然結(jié)合，進(jìn)而溶解細(xì)胞。 </p><p> 蜂毒中的磷脂酶A皇約占全毒于重的8％～l2％，由128個氨基酸組成磷脂酶活性較高，水解磷脂的脂肪鏈，使卵磷脂成為溶血卵磷脂起間接溶血作用．是間接溶血毒： </p> <p> 蜂毒的藥理研究 </p> <p> 對神經(jīng)系統(tǒng)的作用蜂毒是向神經(jīng)性的，在大腦網(wǎng)狀組織}具有阻滯作用和溶膽堿活性，并能改變皮層的生物電活性、尤其是蜂毒肽對N一膽堿受體有選擇性阻滯作用，可使***系統(tǒng)突觸內(nèi)興奮傳導(dǎo)阻滯。 </p> <p> ***作用蜂毒肽能***20～30種革蘭陽性和陰***原微生物的生長繁殖，并能對抗對青霉素耐藥的金黃色葡萄球菌，還能增強磺胺類和青霉素類***的***斂力一 </p> <p> <br /> 氣微香并有較強的刺激性。</p><div style="width:100%;text-align: center;"><img style="max-width: 640px; max-height: 320px;" alt="山西蜂毒,蜂毒" src="https://tyunfile.71360.com/WaterMark/UploadFile/shlinchen/637291455967539063/1397395.png"></div><p> 蜂毒的***活性 </p> <p> 蜂毒明肽的***作用除與它能***垂體-腎上腺系統(tǒng)有關(guān)外，它還抑 </p> <p> 制5-羥色胺和葡萄糖引起的炎性水腫，也能***巴豆油引起的滲出性炎 </p> <p> 癥(蜂毒明肽30ug/kg的***率38.5%，氫化可的松2.5mgkg的***率 </p> <p> 65.7%) .而對其他類型的炎癥沒有作用。MCD-肽作為蜂毒中的一種*** </p> <p> 肽，其***作用是氫化可的松的100倍。其***作用除能刺激垂體~腎上 </p> <p> 腺系統(tǒng)外，還可能與降低***通透性和阻止白細(xì)胞游走等機制有關(guān)。 </p> <p> 安度肽是-種***鎮(zhèn)痛活性很強的多肽，它對前列腺合成酶的***作用 </p> <p> 是***痛的70倍。蜂毒肽(mPlilfin)是蜂毒的主要成分．約占蜂毒于重的 50％。山西蜂毒</p><p style="text-indent:25px">1只工蜂排毒量大約為0.15～0.3毫克左右，也就是說大約需要7000只蜜蜂才能生產(chǎn)出1克蜂毒。山西蜂毒</p><p> 1972年，Habermant報道1μmol/L的蜂毒肽就能阻止**細(xì)胞增殖但卻不***正常細(xì)胞的生長與克隆率。 </p> <p> <br /> </p> <p> 1983年，Vlasak等用mRNA-DNA逆轉(zhuǎn)錄的方法，利用質(zhì)粒pBR322構(gòu)建了蜂王毒腺的cDNA文庫，用蜂王毒腺總mRNA制作探針從此文庫中分離得到了蜂毒肽的cDNA，再進(jìn)一步將其克隆到質(zhì)粒pUC18上進(jìn)行DNA序列分析，由DNA的序列分析結(jié)果推測出的蜂毒肽序列與實際測得的完全相同。 </p> <p> <br /> </p> <p> 1996年，Arora通過對正常大鼠肝細(xì)胞與大鼠肝*細(xì)胞抗缺氧損傷能力的實驗對比，證實蜂毒肽***磷脂酶A2(PLA2)能夠解除肝*細(xì)胞對缺氧的抵抗。DUnn等將來自于鼠抗人骨髓瘤細(xì)胞和淋巴瘤細(xì)胞表面特異蛋白的抗體SCFV基因同蜂毒肽基因相融合，構(gòu)建了能殺**細(xì)胞的抗***基因，大腸桿菌中融合基因并表達(dá)，精制的抗***顯示了體外殺死**細(xì)胞的效能。 Kindas等從處女蜂王的毒腺中提取得到了總mRNA，發(fā)現(xiàn)蜂毒肽mRNA含大約400個堿基對和1個短的polyA尾。 Haase實驗表明蜂毒肽可以***細(xì)胞脂酶，包括磷脂酶C(PLC)、磷脂酶D(PLD)、磷脂酶A2(PLA2)及甘油三酯酶等。山西蜂毒</p><p style="text-indent:25px">上海臨辰醫(yī)藥科技有限公司致力于醫(yī)藥、保養(yǎng)，以科技創(chuàng)新實現(xiàn)***管理的追求。上海臨辰醫(yī)藥作為Plasdone?聚維酮(PVP)，Polyplasdone?交聯(lián)聚維酮(PVPP)，Plasdone?共聚維酮（PVP/VA)，Benecel?羥丙甲纖維素(HPMC)，Klucel?羥丙纖維素(HPC) 硬脂富馬酸鈉，羧甲基淀粉鈉，交聯(lián)羧甲基纖維素鈉，微晶纖維素，磷酸氫鈣（無水/二水）USP-NF,Ph.Eur,JP" D-(+)-半乳糖（植物）蔗糖，異麥芽糖，異麥芽酮糖醇，三氯蔗糖，環(huán)氨酸鈉（甜蜜素)，赤蘚糖醇丁香酚，丁香油，蓖麻油，芝麻油，橄欖油，中鏈甘油三酸酯，乙酰單酸甘油乙酯，蔗糖脂肪酸酯聚乙二醇3350/1000/4000/6000/8000，白陶土，液體石蠟，輕質(zhì)液體石蠟，（干燥）氫氧化鋁凝膠，薄荷腦，合成鋁碳酸鎂，合成硅酸鋁，氧化鎂，氫氧化鎂，甘羥鋁，甘氨酸鋁，磷酸鈣（二水/無水），三硅酸鎂，滑石粉，BHA,BHT,多庫酯鈉，組氨酸，鹽酸組氨酸，精氨酸，鹽酸精氨酸，絲氨酸，半胱氨酸，丙氨酸， Pfanstiehl海藻糖（二水），蔗糖（甘蔗/甜菜），甘露醇，精氨酸，琥珀酸二鈉（無水），氨丁三醇 (含低內(nèi)*素），活性炭（供注射）色素系列黃/紅氧化鐵，檸檬黃色淀，的品牌企業(yè)，為客戶提供質(zhì)量的[ "泛解酸內(nèi)酯", "有機可可粉有機果粉", "阿拉伯膠瓜爾膠 ", "BIS TRIS " ]。公司終堅持自主研發(fā)創(chuàng)新發(fā)展理念，不斷優(yōu)化的技術(shù)、產(chǎn)品為客戶帶來效益，目前年營業(yè)額達(dá)到300-500萬元。上海臨辰醫(yī)藥始終關(guān)注自身，在風(fēng)云變化的時代，我們對自身的建設(shè)毫不懈怠，高度的專注與執(zhí)著使我們在行業(yè)的從容而自信。</p></p><br /><p>文章來源地址: http://www.cdcfah.com/cp/637102.html</p></div></div></div></div></div><div id="l2wqnp9" class="page-right twoColRt"><div id="cwdvxed" class="box01 margin10 clearfix"><h3><a href="http://www.cdcfah.com/cp/">猜你喜歡</a></h3><div id="k23pwt4" class="recomPic likePro"><a href="http://www.cdcfah.com/cp/814588.html"><div><img 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